Comparison of psychiatric disturbances in patients with multiple sclerosis and neuromyelitis optica

Shin, Joon Sung; Kwon, Young Nam; Choi, Yoobin; Lee, Jae Yeon; Lee, Yoonji Irene; Hwang, Ju Hyun; Choi, Soo-Hee; Kim, Sung-Min

doi:10.1097/md.0000000000017184

Cited by 20 publications

(12 citation statements)

References 52 publications

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“…The depressive symptoms observed in patients with MS can precede the onset of neurological symptoms, suggesting that depression may be related to early disease-specific processes ( 54 ). Both MS and major depressive disorder share the common pathophysiology of demyelination of CNS regions and are associated with neuro-inflammation processes ( 55 , 56 ). Indeed, previous CPZ mouse models have reported depression-like symptoms and myelin deficiency ( 19 , 30 ) demonstrating a possible correlation between depression and demyelination of the CNS.…”

Section: Discussionmentioning

confidence: 99%

Low‑field magnetic stimulation improved cuprizone‑induced depression‑like symptoms and demyelination in female mice

et al. 2022

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Depression is a common and disabling comorbidity of multiple sclerosis (MS), with currently no clear guidelines for treatment. Low-field magnetic stimulation (LFMS), a novel non-invasive neuromodulation intervention, has been previously demonstrated to rapidly alleviate mood disorders. The aim of the present study was to investigate the effects of LFMS on depression-like behaviors and demyelination in a well-established mouse model of MS. C57BL/6 female mice were fed a 0.2% cuprizone (CPZ) diet for 3 or 6 weeks to induce acute demyelination. During this time, the mice were treated with either sham or LFMS for 20 min/day, 5 days/week. After 3 or 6 weeks of treatment, behavior was assessed with the open field task, Y-maze and the forced swim test. The prefrontal cortex and hippocampus were then collected to perform immunohistochemistry and western blot analysis to verify myelination status. The CPZ diet did not cause significant locomotor deficits; however, working memory, measured using the Y maze, depression-like behavior and adaptive learning, assayed using the forced swim test, were significantly impaired in these animals. LFMS treatment demonstrated a significant antidepressant-like effect and markedly attenuated the CPZ-induced demyelination in the prefrontal cortex after 3-and 6-weeks of treatment, as observed by changes in myelin basic protein immunostaining and western blot analysis. Therefore, the results of the present study indicated that LFMS may be a promising therapy for demyelinating diseases due to the improvement of depressive symptoms via regulation of myelination in cortical areas.

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Section: Discussionmentioning

confidence: 99%

Low‑field magnetic stimulation improved cuprizone‑induced depression‑like symptoms and demyelination in female mice

et al. 2022

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“…Sung Shin et al found that MS and NMOSD patients had emotional problems. MS patients had depression, anxiety, aggression, paranoia, interpersonal sensitivity, self-regulation problems, stress vulnerability, and poor QoL compared with NMOSD patients, but NMOSD patients were more hopeless [24]. "Living at a bottleneck" was another category that emerged in the patients with MS, and, with a little of difference, "living with limitations" emerged in the patients with NMOSD.…”

Section: Discussionmentioning

confidence: 99%

Explaining the Individual Challenges Experienced of Women Affected by Neuromyelitis Optica and Multiple Sclerosis: A Comparative Content Analysis Study

Shabany

Ayoubi

NaserMoghadasi

et al. 2021

Preprint

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Introduction: Multiple Sclerosis (MS) and Neuro-Myelitis Optica spectrum disorder (NMOSD) are an autoimmune condition. Both of them have unexpected and acute relapses. The aim of this qualitative study was explaining the individual problems experienced of women affected by NMOSD and MS.Method: Sixteen NMOSD patients and eighteen MS patients completed a face to face deep semi-structured interview. Participants were recruited from the MS ward in Sina hospital. After typed the interview, the data were analyzed using conventional content analysis, as recommended by Graneheim and Lundman (2005). Data analysis is managed with MAXQDA2018 software.Results: In this study, a common theme for both disease groups was identified as "challenges arising from personal problems". The categories are named after each other and have many similarities, which in the NMOSD group include four categories including: "From uncertainty to the perception of threat", "Living with limitations", "Active coping until normalization" and "Facilitators of personal problems" appeared. In the group of patients with MS, five categories emerged: "perceived threat", living at a bottleneck, trying to deal with negative experiences, "facilitators of personal problems" and "problems related to physical rehabilitation".Conclusion: This qualitative study showed that the individual problems of the two groups of NMOSD and MS patients are somewhat similar. Also in the present study, people with MS need longer-term rehabilitation care than people with NMOSD, which should be considered and examined, a need that was less seen in people with NMOSD. The unpredictability of attacks in NMOSD and MS can have a profound effect on the daily lives of these people. Therefore, educating patients and staff about how to manage life in such diseases can be an important help to improve patient's health.

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“…Apart from an increased prevalence of RLS in individuals with NMOSD (45.8% vs 28.7%), 3 no clear sleep differences were found between individuals with NMOSD and individuals with MS. Eaneff et al 22 did report a higher prevalence of moderate or excessive daytime sleepiness in individuals with MS through a nonvalidated questionnaire (41% vs 28% in NMOSD, P < .005), but this result contradicted that of Shaygannejad et al, 3 who found no significant differences in daytime sleepiness between 24 individuals with NMOSD and 359 individuals with MS. Similarly, Shin et al 17 found no difference between the scores of individuals with NMOSD and individuals with MS on the "sleep problem" subscale of the Symptom Checklist-95.…”

Section: Comparison With Msmentioning

confidence: 95%

“…After screening, 13 studies remained and were included for analysis (Figure S1). 3,7,10,[15][16][17][18][19][20][21][22][23][24] All of the included studies had cross-sectional designs. Most of the studies were conducted in Asia (ten of 13), with four…”

Section: Study Characteristicsmentioning

confidence: 99%

Sleep Quality in Neuromyelitis Optica Spectrum Disorder: A Systematic Review

Eshtiaghi¹,

Eapen-John²,

Zaslavsky³

et al. 2021

International Journal of MS Care

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Background: This review summarizes the literature on sleep quality in neuromyelitis optica spectrum disorder (NMOSD) and discusses these findings in the context of current knowledge of sleep physiology. Methods: A literature search was performed using Ovid MEDLINE, Embase, and Scopus from inception to September 3, 2020. All included studies reported at least one measure of sleep quality in individuals with NMOSD. Pittsburgh Sleep Quality Index (PSQI) scores of individuals from four studies were compared with those from a data set of controls. Results: Thirteen studies (1041 persons with NMOSD) were included in the review. Disturbed sleep was demonstrated across subjective metrics based on patient surveys and objective metrics such as polysomnography. An estimated 70% of individuals with NMOSD can be classified as poor sleepers. Standardized mean difference between PSQI scores of 183 individuals with NMOSD and those of 9284 controls was 0.72 (95% CI, 0.57–0.86; P < .001). Decreased sleep quality was significantly associated with decreased quality of life and increased anxiety, depression, and disability status. Sleep disturbances in NMOSD were similar in severity to those in multiple sclerosis. Conclusions: Sleep disturbances are a major contributor to NMOSD disease burden and may arise from the disruption of sleep circuitry, in addition to physical and psychological complications. Multiple processes involved in sleep regulation may be affected, such as, but not limited to, neural circadian circuit disruption, direct effects of inflammation, aminergic projecting system abnormalities, glymphatic system impairment, and development of sleep disorders such as restless legs syndrome/sleep apnea. A better understanding of these mechanisms is necessary for developing effective therapies for NMOSD-associated sleep disturbances.

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Comparison of psychiatric disturbances in patients with multiple sclerosis and neuromyelitis optica

Cited by 20 publications

References 52 publications

Low‑field magnetic stimulation improved cuprizone‑induced depression‑like symptoms and demyelination in female mice

Low‑field magnetic stimulation improved cuprizone‑induced depression‑like symptoms and demyelination in female mice

Explaining the Individual Challenges Experienced of Women Affected by Neuromyelitis Optica and Multiple Sclerosis: A Comparative Content Analysis Study

Sleep Quality in Neuromyelitis Optica Spectrum Disorder: A Systematic Review

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