Comparison of Pulegone and Estragole Chemotypes Provides New Insight Into Volatile Oil Biosynthesis of Agastache rugosa

Dang, Jingjie; Lin, Guyin; Liu, Licheng; Zhou, Peina; Shao, Yongfang; Dai, Shilin; Sang, Mengru; Jiang, Zheng; Liu, Chanchan; Wu, Qinan

doi:10.3389/fpls.2022.850130

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…The authors reported these accessions were grouped into two major clusters (A and B), and cluster A is subdivided into two sub-clusters. Furthermore, Dang et al [ 25 ] compared morphological features and essential oil compositions in the pulegone and estragole chemotypes of A. rugosa. Previous studies also found that the morphological variations among different chemotypes were mainly in leaf type, trichome density, plant height, and internode length [ 26 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…Similar to our study, Li et al [ 18 ] isolated the essential oils of A. rugosa aerial parts collected from Zhejiang, Hubei, and Henan provinces of China and found three different chemotypes, pulegone, estragole, and methyl eugenol, were major components, respectively. The morphological variations, essential oil components, and transcriptomic data between the two chemotypes of A. rugosa , pulegone and estragole, were also investigated [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…The chemical composition characteristics of each cluster are shown in Table 5 . Dang et al [ 25 ] reported that 46 genes were identified with the biosynthesis of estragole and pulegone. In these, the authors identified chavicol methyl transferase and limonene-3-hydroxylase in A. rugosa .…”

Section: Resultsmentioning

confidence: 99%

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Chemical Diversity of Essential Oils from Korean Native Populations of Agastache rugosa (Korean Mint)

Hong

Deepa

Lee³

et al. 2022

Molecules

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Agastache rugosa (baechohyang) is one of the most important aromatic plants native to the Republic of Korea. A. rugosa fragrance has been used to prepare incense since the Goryeo Dynasty in Korea. The present study aimed to explore the variation in the composition of essential oils from A. rugosa among native populations in Korea. The seeds of A. rugosa were collected from 90 different sites in Korea and seedlings were raised in the nursery. Essential oils were extracted from these populations by the steam distillation extraction method and their chemical compositions were analyzed by GC-MS. The yield of essential oils of A. rugosa ranged between 0.11% and 0.86%. A total of 204 components were identified from 90 populations of A. rugosa. Out of 204 components, 32 components were common in more than 40 individuals of A. rugosa and these 32 components were selected for principal component analysis (PCA). On the basis of the essential oil compositions, six chemotypes—estragole, pulegone, methyl eugenol, menthone, isopulegone, and nepetalactone—were distinguished according to their major components. As a result of the cluster analysis, 90 individuals of A. rugosa could be classified into three groups: estragole, methyl eugenol, and pulegone. A. rugosa exhibited significant chemical diversity among the individuals. The distribution of chemotypes is associated with the collection of seeds, suggesting that genetic diversity may influence the variations in the chemical compositions and concentrations within the species. This chemical diversity serves as the background to select cultivars for the cultivation and industrial applications of A. rugosa cultivars with high essential oil yield and concentration of its chemical components.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Chemical Diversity of Essential Oils from Korean Native Populations of Agastache rugosa (Korean Mint)

Hong

Deepa

Lee³

et al. 2022

Molecules

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“…Estragole and methyl eugenol were not found in the pulegone chemotype. In contrast, the major compounds of the volatile oil in the estragole chemotype were estragole and caryophyllene [ 55 ].…”

Section: Phytochemical Profilementioning

confidence: 99%

Agastache Species: A Comprehensive Review on Phytochemical Composition and Therapeutic Properties

Nechita

Toiu

Benedec

et al. 2023

Plants

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The Agastache genus is part of the Lamiaceae family and is native to North America, while one species, Agastache rugosa (A. rugosa), is native to East Asia. A review on the phytochemistry and bioactivity of Agastache genus was last performed in 2014. Since then, a lot of progress has been made on the characterization of the phytochemical and pharmacological profiles of Agastache species. Thus, the purpose of this paper is to present a summary of the findings on the phytochemistry and biological effects of several Agastache species, including both extracts and essential oil characterization. We performed a comprehensive search using PubMed and Scopus databases, following PRISMA criteria regarding the study selection process. The available data is focused mainly on the description of the chemical composition and bioactivity of A. rugosa, with fewer reports referring to Agastache mexicana (A. mexicana) and Agastache foeniculum (A. foeniculum). Agastache species are characterized by the dominance of flavonoids and phenolic acids, as well as volatile compounds, particularly phenylpropanoids and monoterpenes. Moreover, a series of pharmacological effects, including antioxidant, cytotoxic, antimicrobial, anti-atherosclerotic, and cardioprotective properties, have been reported for species from the Agastache genus.

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“…Analyses of phytochemotype classification and its formation mechanism had both theoretical and practical values in guiding the development & utilization, quality evaluation and oriented cultivation of plant germplasm resources ( Desjardins, 2008 ). Although standards of chemotype classification and nomenclature for different plant species have not been unified ( Hua et al., 2009 ), intraspecific chemotype variations were found and studied in several tens plants including Agastache rugosa, Cannabis sativa , and Valeriana jatamansi since the concept proposed ( He et al., 2018 ; Jin et al., 2021 ; Dang et al., 2022 ). Because of the development of statistical analysis for high dimensional data, and the maturity of chromatograph-mass spectrometer technologies, the high-throughput detection of plant metabolomics provided whole and new perspectives for accurate chemotype classification and evaluation, and related metabolic regulatory mechanisms ( Deng et al., 2020 ; Yang et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Analysis of chemotypes and their markers in leaves of core collections of Eucommia ulmoides using metabolomics

Meng

Du²,

Du³

et al. 2023

Front. Plant Sci.

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The leaves of Eucommia ulmoides contain various active compunds and nutritional components, and have successively been included as raw materials in the Chinese Pharmacopoeia, the Health Food Raw Material Catalogue, and the Feed Raw Material Catalogue. Core collections of E. ulmoides had been constructed from the conserved germplasm resources basing on molecular markers and morphological traits, however, the metabolite diversity and variation in this core population were little understood. Metabolite profiles of E. ulmoides leaves of 193 core collections were comprehensively characterized by GC-MS and LC-MS/MS based non-targeted metabolomics in present study. Totally 1,100 metabolites were identified and that belonged to 18 categories, and contained 120 active ingredients for traditional Chinese medicine (TCM) and 85 disease-resistant metabolites. Four leaf chemotypes of the core collections were established by integrated uses of unsupervised self-organizing map (SOM), supervised orthogonal partial least squares discriminant analysis (OPLS-DA) and random forest (RF) statistical methods, 30, 23, 43, and 23 chemomarkers were screened corresponding to the four chemotypes, respectively. The morphological markers for the chemotypes were obtained by weighted gene co-expression network analysis (WGCNA) between the chenomarkers and the morphological traits, with leaf length (LL), chlorophyll reference value (CRV), leaf dentate height (LDH), and leaf thickness (LT) corresponding to chemotypes I, II, III, and IV, respectively. Contents of quercetin-3-O-pentosidine, isoquercitrin were closely correlated to LL, leaf area (LA), and leaf perimeter (LP), suggesting the quercetin derivatives might influence the growth and development of E. ulmoides leaf shape.

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Comparison of Pulegone and Estragole Chemotypes Provides New Insight Into Volatile Oil Biosynthesis of Agastache rugosa

Cited by 10 publications

References 25 publications

Chemical Diversity of Essential Oils from Korean Native Populations of Agastache rugosa (Korean Mint)

Chemical Diversity of Essential Oils from Korean Native Populations of Agastache rugosa (Korean Mint)

Agastache Species: A Comprehensive Review on Phytochemical Composition and Therapeutic Properties

Analysis of chemotypes and their markers in leaves of core collections of Eucommia ulmoides using metabolomics

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