“…Because of its descriptive nature, this study cannot be used to change clinical practice. However, given that evidence for or against use of PAC originates mainly from observational studies [ 1 , 8 , 10 , 16 , 17 , 20 , 21 , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] ], it can provide insights for the future design and conduct of large randomized trials aimed at evaluating safety, efficacy, and cost-effectiveness of PAC use within this clinical population.…”