Comparison of pulsed field gel electrophoresis patterns of Bordetella pertussis isolates from unvaccinated children with severe or mild pertussis

Heininger, Ulrich; Frei, Reno; Cherry, James D.; Stehr, K.

doi:10.1097/01.inf.0000115502.94265.df

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Bisgard et al (29) found no association between PFGE profiles of isolates (n=226) collected during 1989–1996 and hospitalisation, or pneumonia among infants. Neither did Heininger et al (30) notice differences in PFGE patterns between unvaccinated children with severe symptoms (n=31) compared with isolates from matched children with mild symptoms (n=32). Their rather small material was collected during a 10–year period beginning in 1990.…”

Section: Discussionmentioning

confidence: 84%

Clinical outcome of pertussis in Sweden: association with pulsed‐field gel electrophoresis profiles and serotype

Advani¹,

Gustafsson²,

Carlsson³

et al. 2007

APMIS

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In Sweden, acellular pertussis vaccines were introduced at 3, 5 and 12 months of age in 1996, after a 17-year hiatus without pertussis vaccination. An intensified surveillance of pertussis was initiated in October 1997, including collection of clinical data as well as Bordetella pertussis isolates in culture or PCR-confirmed cases of pertussis among children born from January 1996 to September 2004. We analysed the association of pulsed-field gel electrophoresis (PFGE) profile and serotype with severity of disease for all children followed during the first 7 years of the project. There were in all 927 children for whom both clinical information and strain characterisation data were available. 260 of these children were hospitalised during the pertussis episode. When duration of hospital stay was compared between children with different groups of strains, characterised by PFGE profile or serotype, there was a significantly higher proportion of children with long duration of hospital stay in the most frequent PFGE profile group (BpSR11) compared to the PFGE group of all other profiles (p=0.041). There was no statistically significant association between serotype and hospitalisation rate or duration of hospital stay, neither was there any statistically significant association between serotype or PFGE profile and duration of spasmodic cough or presence of complications.

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Section: Discussionmentioning

confidence: 84%

Clinical outcome of pertussis in Sweden: association with pulsed‐field gel electrophoresis profiles and serotype

Advani¹,

Gustafsson²,

Carlsson³

et al. 2007

APMIS

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“…PFGE patterns of B. pertussis isolates from children with severe disease were recently compared with those of strains isolated from children with mild disease. Interestingly, variability in the severity of pertussis was not attributed to a specific PFGE profile or 'supervirulent' clones [78]. This reduces concerns regarding selection of novel B. pertussis strains with increased virulence that may potentially cause epidemics.…”

Section: Germanymentioning

confidence: 98%

Are vaccination programs and isolate polymorphism linked to pertussis re-emergence?

Godfroid¹,

Denoël²,

Poolman³

2005

Expert Review of Vaccines

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Whooping cough remains an endemic disease, and the re-emergence of pertussis in older children and adolescents has been reported in several countries, despite high vaccine coverage. Polymorphism of Bordetella pertussis has been observed over time, and some characteristics of pertussis isolates have gradually diverged from the vaccine strains. The present review summarizes the current knowledge on B. pertussis variability in countries with different vaccination programs and discusses its potential impact on the recently observed increased incidence of whooping cough. No direct association between B. pertussis isolate variability and vaccination programs has been observed to date, except for shifts from fimbriae Fim2 to Fim3. More likely explanations for the re-emergence of pertussis include the change in the epidemiology and transmission patterns of pertussis in highly vaccinated populations, and a shift of disease from young children to adolescents and adults due to waning protective immunity.

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Pertussis

Weisberg¹

2007

Disease-a-Month

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Comparison of pulsed field gel electrophoresis patterns of Bordetella pertussis isolates from unvaccinated children with severe or mild pertussis

Abstract: Differences in virulence of circulating B. pertussis strains can be absent or might not correlate with specific PFGE patterns. Other methods should be evaluated to identify differences in virulence.

Cited by 7 publications

References 20 publications

Clinical outcome of pertussis in Sweden: association with pulsed‐field gel electrophoresis profiles and serotype

Clinical outcome of pertussis in Sweden: association with pulsed‐field gel electrophoresis profiles and serotype

Are vaccination programs and isolate polymorphism linked to pertussis re-emergence?

Pertussis

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