Comparison of Quality of Life After Transnasal Endoscopic vs Open Skull Base Tumor Resection

Abergel, Avraham; Cavel, Oren; Margalit, Nevo; Fliss, Dan M.; Gil, Ziv

doi:10.1001/archoto.2011.1146

Cited by 89 publications

(72 citation statements)

References 36 publications

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“…8 In this respect, the only study to compare subcranial and endoscopic approaches showed that patients treated endoscopically had significantly better QOL scores in the physical function and emotions domains than those treated with open surgery. 1 As stated, our study presents several strong points with regard to previous publications: a validated questionnaire, the same investigators to administer the questionnaire, and a large and homogeneous cohort of patients with similar pathologies and treatments.…”

Section: Discussionmentioning

confidence: 69%

Quality of life following endoscopic endonasal resection of anterior skull base cancers

Castelnuovo

Lepera

Turri‐Zanoni

et al. 2013

JNS

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Object For several decades, the exclusive purpose in the management of anterior skull base malignancies has been to increase survival rates. Recently, given the improved prognosis achieved, more attention has been focused on quality of life (QOL) as well. Producing data on QOL in anterior skull base cancers is hampered by the rarity of the neoplasm and the lack of specific questionnaires. The purpose of this study was to assess health-related QOL in a large and homogeneous cohort of patients affected by anterior skull base cancers who had undergone endoscopic endonasal resection. Methods The authors conducted a retrospective review of patients treated for sinonasal and skull base cancers via an endoscopic endonasal approach at two Italian tertiary care referral centers. All patients were asked to complete the Anterior Skull Base Surgery Questionnaire to evaluate their QOL before and 1 month and 1 year after surgical treatment. To assess which parameters affect QOL, the study population was divided into subgroups according to age, sex, stage of disease, surgical approach, and adjuvant therapy. Results One hundred fifty-three patients were enrolled in this study according to the adopted inclusion criteria. Overall QOL started at a score of 4.68 for the preoperative period, sharply decreased as far as a score of 4.03 during the 1st postoperative month, and rose again to a score of 4.59 over the course of 1 year after treatment, with a significant difference among the 3 values (p < 0.05). The specific symptoms and physical status domains registered poorer results at the 1-year assessment (4.00 and 4.71, respectively) than at the preoperative assessment (both domains 4.86), with a statistically significant reduction in scores (p < 0.05). Worse outcomes were associated with several variables: age > 60 years (difference of 0.21 points between the preoperative and 1-year period, p < 0.05), expanded surgical approaches with transnasal craniectomy (decrease of 0.20 points between the preoperative and 1-year period, p < 0.05), and postoperative radiotherapy (score of 4.53 at the 1-year period vs 4.70 in patients without any adjuvant treatment, p < 0.05). No statistically significant differences were found when analyzing the study population according to sex (p > 0.1) and T classification of disease at presentation (p > 0.05). Conclusions Radical endoscopic endonasal resection led to either complete or at least partial recovery of patient QOL within the 1st postoperative year.

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Section: Discussionmentioning

confidence: 69%

Quality of life following endoscopic endonasal resection of anterior skull base cancers

Castelnuovo

Lepera

Turri‐Zanoni

et al. 2013

JNS

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“…In our study we have not observed any tumour recurrence or persistence but we showed that the sinonasal mucosa remains with inflammatory signs up to 12 months after surgery especially on T2-weighted images. One has to keep in mind all the exposed evidence when deciding to use other imaging tests such as PET-CT because the inflamed cells also show increased glycolytic activity, consequently inflamed areas cannot be distinguish with tumour tissue [50][51][52][53].…”

Section: Radiological Findingsmentioning

confidence: 99%

Postoperative Findings in Endoscopic Endonasal Surgery of The Skull Base

Langdon

Santamaría

Forner-Cordero

et al. 2017

JOENTR

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Since the introduction of endonasal endoscopic skull base surgery the exclusive purpose in the management of skull base neoplasms has been to increase survival rates. Recently, given the improved prognosis achieved, more attention has been focused on the functional outcomes such as nasal symptoms and quality of life (QOL). The purpose of this review is to assess the functional outcomes after endonasal endoscopic skull base surgery.

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“…Meticulous attention to the sinonasal anatomy preserves function and translates to improved quality of life as compared to other approaches and allows patients to return to their baseline nasal function more quickly post-operativley (1,15). The primary goals, like those for inflammatory disease, remain mucosal preservation techniques that maintain ostia patency and prevent scar formation.…”

Section: Perioperativementioning

confidence: 99%

Comprehensive Management of the Paranasal Sinuses in Patients Undergoing Endoscopic Endonasal Skull Base Surgery

Nyquist¹,

Rosen²,

Friedel³

et al. 2014

World Neurosurgery

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Comparison of Quality of Life After Transnasal Endoscopic vs Open Skull Base Tumor Resection

Abstract: In certain domains, quality of life after endoscopic skull base surgery appears to be better than that after open approaches.

Cited by 89 publications

References 36 publications

Quality of life following endoscopic endonasal resection of anterior skull base cancers

Quality of life following endoscopic endonasal resection of anterior skull base cancers

Postoperative Findings in Endoscopic Endonasal Surgery of The Skull Base

Comprehensive Management of the Paranasal Sinuses in Patients Undergoing Endoscopic Endonasal Skull Base Surgery

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