Comparison of Quality of Life in Breast Cancer Survivors with and without Persistent Depressive Symptoms: A 12-Month Follow-Up Study

Ribeiro, Fernanda Elisa; Tebar, William Rodrigues; Ferrari, Gérson; Palma, Mariana Romanholi; Fregonesi, Cristina Elena Prado Teles; Caldeira, Daniela Tanajura; Silva, Gabriela Caroline Rodrigues; Vanderlei, Luiz Carlos Marques; Beretta, Victor Spiandor; Christófaro, Diego Giulliano Destro

doi:10.3390/ijerph20043663

Cited by 6 publications

(4 citation statements)

References 51 publications

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“…However, at this point, patients who have experienced distress may have a slow recovery process and persistent physical and psychological symptoms 20 . During this period, breast cancer patients who experience ongoing distress may not only experience delays in adaptation and recovery in their daily lives 21 , 22 , but also face difficulties in readjusting to societal requirements, such as returning to work, thereby resulting in a lower quality of life. However, note that many breast cancer patients do not receive any specific management beyond regular hospital visits after their treatment is completed.…”

Section: Discussionmentioning

confidence: 99%

“…These symptoms are observed from the time of diagnosis and can last for more than 10 years after treatment has ended 30 . These emotional issues have been identified as the most important variables that influence the quality of life and adaptation of breast cancer patients following primary treatment 22 , 31 . Considering that the association between these emotional symptoms and long-term survival rates in cancer patients has been established 32 , emotional symptoms must be monitored continuously and comprehensive approaches for mental health promotion, such as psychological support and counseling specifically designed for breast cancer survivors, must be implemented.…”

Section: Discussionmentioning

confidence: 99%

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Factors influencing psychological distress among breast cancer survivors using machine learning techniques

Park,

Chun,

Bae

et al. 2024

Sci Rep

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Breast cancer is the most commonly diagnosed cancer among women worldwide. Breast cancer patients experience significant distress relating to their diagnosis and treatment. Managing this distress is critical for improving the lifespan and quality of life of breast cancer survivors. This study aimed to assess the level of distress in breast cancer survivors and analyze the variables that significantly affect distress using machine learning techniques. A survey was conducted with 641 adult breast cancer patients using the National Comprehensive Cancer Network Distress Thermometer tool. Participants identified various factors that caused distress. Five machine learning models were used to predict the classification of patients into mild and severe distress groups. The survey results indicated that 57.7% of the participants experienced severe distress. The top-three best-performing models indicated that depression, dealing with a partner, housing, work/school, and fatigue are the primary indicators. Among the emotional problems, depression, fear, worry, loss of interest in regular activities, and nervousness were determined as significant predictive factors. Therefore, machine learning models can be effectively applied to determine various factors influencing distress in breast cancer patients who have completed primary treatment, thereby identifying breast cancer patients who are vulnerable to distress in clinical settings.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Factors influencing psychological distress among breast cancer survivors using machine learning techniques

Park,

Chun,

Bae

et al. 2024

Sci Rep

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“…This questionnaire can be used repeatedly to assess changes in habitual physical activity as it covers qualitative and quantitative indexes and addresses a variety of physical activity dimensions. Validity, reproducibility, and reliability were tested in various populations [ 24 – 26 ] including cancer survivors [ 27 , 28 ].…”

Section: Methodsmentioning

confidence: 99%

Habitual physical activity modulates cardiometabolic health in long-term testicular cancer survivors

Amiri,

Krumpolec,

Mego

et al. 2023

Support Care Cancer

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Purposes Physical activity (PA) may mitigate late cardiometabolic toxicity of cisplatin-based chemotherapy in testicular germ cell tumor (TGCT) long-term survivors. In this cross-sectional study, we evaluated the effects of habitual PA on metabolic syndrome (MetS) prevalence, and on the markers of cardiometabolic health and chronic inflammation in a population of long-term TGCT survivors. Methods MetS prevalence was evaluated, and habitual PA was assessed using Baecke’s habitual PA questionnaire in TGCT survivors (n=195, age=41.1±8.1years, 11.7±5.2years post-therapy) and healthy male controls (n=41, age=38.2±8.8years). Participants were stratified into low- and high-PA groups based on median values. Differences were examined between low- and high-PA groups (in the entire sample, TGCT survivor sub-samples differing in disease stage, and healthy controls), and between TGCT survivors and controls. Next, TGCT survivors were stratified into age- and BMI-matched sub-groups based on post-treatment time (5–15/15/30years) and number of chemotherapy cycles (≤3/>3), allowing us to detect age- and BMI-independent effects of habitual PA on cardiometabolic health in the given TGCT survivor sub-populations. A correlation matrix of habitual PA and sport activity with cardiometabolic and pro-inflammatory markers was generated. Results TGCT survivors had higher MetS prevalence than controls. Patients with high habitual PA had lower waist circumference and Systemic Inflammation Index. Habitual PA scores correlated positively with HDL-cholesterol and negatively with waist circumference and atherogenic risk. Furthermore, cardiometabolic benefits of habitual PA were more pronounced in patients with disease stages 1 and 2. Effects of habitual PA on patients sub-populations stratified by chemotherapy dose and post-treatment time clearly showed that higher levels of habitual PA were associated with lower numbers of MetS components, except for patients who received more than 3 chemotherapy cycles and were examined more than15 years post-therapy. Conclusions Higher levels of habitual PA effectively mitigated cardiometabolic toxicity in TGCT survivors. Patients with higher cumulative doses of chemotherapy may need structured exercise interventions involving higher-intensity physical activity to achieve significant improvements in cardiometabolic health.

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“…The main clinical manifestations for breast cancer survivors (BCSs) include postoperative defect on the side of the operation, cicatricial changes [ 16 ], plexopathy of the brachial plexus [ 17 , 18 ], impaired biomechanics in the shoulder joint [ 19 ], anxiety and depressive disorders [ 20 , 21 ], lymphedema of the upper limb [ 9 , 22 , 23 , 24 ], and vestibulo-atactic syndrome (VAS) [ 25 ]. Disorders of the central nervous system (CNS) that occur against the background of the complex treatment of breast cancer can lead to functional and structural changes in the brain of patients in the postoperative period, such as changes in functional connectivity in the Default Mode Network and quantitative fractional anisotropy in the white matter tracts [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Elevated Levels of Serum Biomarkers Associated with Damage to the CNS Neurons and Endothelial Cells Are Linked with Changes in Brain Connectivity in Breast Cancer Patients with Vestibulo-Atactic Syndrome

Nikolaeva,

Pospelova,

Krasnikova

et al. 2023

Pathophysiology

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Vestibulo-atactic syndrome (VAS), which represents a combination of motor and vestibular disorders, can be manifested as a clinical complication of breast cancer treatment and has a significant impact on patients’ quality of life. The identification of novel potential biomarkers that might help to predict the onset of VAS and its progression could improve the management of this group of patients. In the current study, the levels of intercellular cell adhesion molecule 1 (ICAM-1), platelet/endothelial cell adhesion molecule 1 (PECAM-1), NSE (neuron-specific enolase), and the antibodies recognizing NR-2 subunit of NMDA receptor (NR-2-ab) were measured in the blood serum of BC survivor patients with vestibulo-atactic syndrome (VAS) and associated with the brain connectome data obtained via functional magnetic resonance imaging (fMRI) studies. A total of 21 patients were registered in this open, single-center trial and compared to age-matched healthy female volunteers (control group) (n = 17). BC patients with VAS demonstrated higher serum levels of ICAM-1, PECAM-1, and NSE and a lower value of NR-2-ab, with values of 654.7 ± 184.8, 115.3 ± 37.03, 49.9 ± 103.9, and 0.5 ± 0.3 pg/mL, respectively, as compared to the healthy volunteers, with 230.2 ± 44.8, 62.8 ± 15.6, 15.5 ± 6.4, and 1.4 ± 0.7 pg/mL. According to the fMRI data (employing seed-to-voxel and ROI-to-ROI methods), in BC patients with VAS, significant changes were detected in the functional connectivity in the areas involved in the regulation of postural-tonic reflexes, the coordination of movements, and the regulation of balance. In conclusion, the detected elevated levels of serum biomarkers may reveal damage to the CNS neurons and endothelial cells that is, in turn, associated with the change in the brain connectivity in this group of patients.

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Comparison of Quality of Life in Breast Cancer Survivors with and without Persistent Depressive Symptoms: A 12-Month Follow-Up Study

Cited by 6 publications

References 51 publications

Factors influencing psychological distress among breast cancer survivors using machine learning techniques

Factors influencing psychological distress among breast cancer survivors using machine learning techniques

Habitual physical activity modulates cardiometabolic health in long-term testicular cancer survivors

Elevated Levels of Serum Biomarkers Associated with Damage to the CNS Neurons and Endothelial Cells Are Linked with Changes in Brain Connectivity in Breast Cancer Patients with Vestibulo-Atactic Syndrome

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