Comparison of Quantitative Ultrasound Measurements in Calcaneus with DXA and SXA at Other Skeletal Sites: A Population-Based Study on 280 Children Aged 11-16 Years

Sundberg, Martin; Gärdsell, Per; Johnell, Olof; Ornstein, Ewald; Sernbo, Ingemar

doi:10.1007/s001980050084

Cited by 67 publications

(31 citation statements)

References 27 publications

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“…The relationship between QUS and DXL investigated in this study in the Swedish population sample could not be compared with that of other studies, as no other studies were available in which both QUS and DXL measurements were recorded. Studies investigating the relationship between the QUS result and the gender and age available for comparison show that, in healthy children, investigators did not find a difference in sex for ultrasound variables, 6,7,10,12 which is also confirmed in our study. The lack of age differences for the SI value in this study compared with others 7,10,12,13,18 is probably a result of the limited number of children in our study population, as well as due to the small age range in this study (3-8 years old).…”

Section: Related To the First Objective Of This Studysupporting

confidence: 79%

The relationship between paediatric calcaneal quantitative ultrasound measurements and dual energy X-ray absorptiometry (DXA) and DXA with laser (DXL) as well as body composition

et al. 2011

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Background: Quantitative ultrasound (QUS) is a quick, non-invasive and inexpensive method to measure bone strength. Moreover, the device is portable, which makes it easy to be used in the field. In contrast to other bone measuring techniques, QUS does not use any ionised radiation. However, the validity of QUS in the measurement of bone health and the relationship between QUS output and body composition have not been assessed in very young children. Objective: To investigate the relationship between paediatric calcaneal QUS and both dual-energy X-ray absorptiometry (DXA) and calcaneal DXA with laser (DXL) and body composition parameters. Subjects: A total of 37 Belgian children (10 boys and 27 girls; 4 to 8 years old) underwent a calcaneal QUS as well as a DXA scan. A total of 24 Swedish children (15 boys and 9 girls; 3 to 5 years old) underwent a calcaneal QUS as well as a heel DXL scan. The height and weight of all children were measured. Results: The QUS stiffness index (SI) was significantly negatively correlated with bone mineral density (BMD) of the total body (r ¼ À0.370, P ¼ 0.02). No significant correlations were found between the SI and DXL results. In the total sample, the SI showed a significant positive correlation with body mass index (BMI) (r ¼ 0.298, P ¼ 0.02), even after correction for age, gender and centre. In the Belgian sample, the SI was also significantly positively correlated with total body fat mass content (r ¼ 0.416, P ¼ 0.01) and body fat percentage (r ¼ 0.566, Po0.01) obtained by whole-body DXA. Conclusion: The SI measured by QUS does not correlate significantly with BMD values measured by DXA or DXL in 3-to 8-year-old children. However, there is a significant positive correlation between SI and BMI and body fat %.

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Section: Related To the First Objective Of This Studysupporting

confidence: 79%

The relationship between paediatric calcaneal quantitative ultrasound measurements and dual energy X-ray absorptiometry (DXA) and DXA with laser (DXL) as well as body composition

et al. 2011

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“…Studies in healthy children and in patients with disturbances of growth, disorders of bone and mineral metabolism, or chronic diseases have shown a wide range of correlation between QUS variables measured at the heel (17,18,27,28,57,60,67), proximal phalanges of the hand (29,30,83,84), midshaft tibia or distal third of the radius (58,85) and central, peripheral, or total body BMD assessed by DXA. A mild correlation (r ϭ 0.22) between calcaneal QUS and radial volumetric total BMD by pQCT was found (35).…”

Section: Comparison Among Qus Methods and Between Qus Methods And DXmentioning

confidence: 99%

“…Anthropometric findings, including pubertal stages, are additional factors influencing QUS variables assessed at the heel (18,25,26,43), proximal phalanges of the hand (16,22,44,45), and tibia or radius (46,47), indicating that skeletal growth and gender-dependent bone maturation are important determinants of QUS measurements; so, the auxologic parameters should be taken into consideration in QUS measurements and clinical interpretation of results.…”

Section: Effect Of Bone Size and Geometry Soft Tissue Thickness Andmentioning

confidence: 99%

Quantitative Ultrasound Methods to Assess Bone Mineral Status in Children: Technical Characteristics, Performance, and Clinical Application

Baroncelli¹

2008

Pediatr Res

229

179

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Measurement of bone mineral status may be a useful tool in identifying the children who could be exposed to an increased risk of osteoporosis in adulthood. Dual energy x-ray absorptiometry and peripheral quantitative computed tomography may be used to this purpose, but the exposure to ionizing radiation is a limiting factor for preventive studies in large populations of children. In the last years, quantitative ultrasound (QUS) methods have been developed to assess bone mineral status in some peripheral skeletal sites such as calcaneus, phalanges of the hand, and tibia. QUS techniques are safe, easy to use, radiation-free, and devices are portable, so that they are particularly indicated to assess bone mineral status in children. This review will concentrate on the main methodological principles of ultrasounds and the QUS variables derived from their application to bone tissue, technical differences and performance of QUS methods, factors influencing QUS measurements, normative data and results obtained in children with disturbances of growth or affected by disorders of bone and mineral metabolism, including the assessment of fracture risk, and comparison among QUS, dual energy x-ray absorptiometry, and peripheral quantitative computed tomography methods. (Pediatr Res 63: 220-228, 2008) I n the last years, the demand for measurement of bone mineral status to identify children who could be exposed to an increased risk of osteoporosis in adulthood is rapidly increased. Several disorders, by various mechanisms, may be associated with a reduced bone mineral status; in particular, patients with chronic or genetic diseases, malignancies, acute or chronic disabilities caused by neuromuscular disorders, and patients receiving prolonged glucocorticoid treatment are at risk of fractures by minimal trauma caused by a severe reduction in bone mineral status (1).Moreover, there is a growing demand for assessing the effects of some environmental factors on bone health, such as dietary habits and various degrees of physical activity by using radiationfree techniques. DENSITOMETRIC TECHNIQUES FOR ESTIMATING BONE MINERAL STATUS IN CHILDRENSome densitometric techniques to assess bone mineral status developed for adults have been adapted for the use in children. Dual energy x-ray absorptiometry (DXA) is the most commonly used technique for bone mineral status assessment worldwide. The main advantages of DXA are its wide availability and short scanning times, but the subject is exposed to ionized radiation that varies according to the machinery and the examined skeletal site; anyway, radiation dose to patient from DXA is minimal (0.08 -4.6 Sv and 6.7-31 Sv for pencil beam and fan beam methods, respectively) compared with that given by many other investigations involving ionizing radiation (2). Nevertheless, an important shortcoming of DXA is that it measures bone in two dimensions providing only an estimation of bone density. Indeed, DXA measures an integral areal density that is calculated as bone mineral content/bone su...

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“…São poucos os estudos em crianças e adolescentes normais comparando os resultados de massa óssea entre a QUS e a DXA (12,19). Sundberg e cols.…”

Section: Discussionunclassified

“…Sundberg e cols. mostraram correlações de 0,44 e 0,70 entre QUS de calcâneo e DXA, com valores mais altos para a DXA de corpo inteiro, avaliando meninos e meninas conjuntamente (19). Halaba e cols.…”

Section: Discussionunclassified

Comparação preliminar entre ultrassonografia quantitativa de falanges e densitometria óssea na avaliação da massa óssea em adolescentes

Duarte

Carvalho

Gonçalves

et al. 2012

Arq Bras Endocrinol Metab

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RESUMOObjetivo: Avaliar associação entre ultrassonografia quantitativa de falanges da mão (QUS) e a densitometria por absorção de raio-X de dupla energia (DXA) e desses com os históricos alimentar e de fraturas. Sujeitos e métodos: Após dois anos de acompanhamento de 270 escolares, 10 com massa óssea por QUS abaixo de -2 DP foram incluídos no estudo e avaliados com DXA. Resultados: A massa óssea por DXA de L1-L4 variou de -2,8 a -1,1 DP e de corpo inteiro -2,9 e -1,2. Três estudantes apresentaram fraturas. Baixa ingestão de cálcio foi observada nos 10 casos, de fósforo em 6 e de vitamina D em 8. Não houve diferença entre os casos com massa abaixo de -2 DP nos três métodos de avaliação. Não foi observada associação entre as fraturas e o histórico alimentar, nem com os valores de massa óssea. Conclusão: Neste pequeno grupo de adolescentes houve associação entre QUS e DXA, porém sem associação entre essas avaliações e as fraturas e a ingestão de cálcio, fósforo e vitamina D. Arq Bras Endocrinol Metab. 2012;56(1):19-24Descritores Cálcio; DXA; ingestão dietética; massa óssea; osteossonografia ABSTRACT Objective: To evaluate the association between quantitative ultrasonography at hand phalanges (QUS) and dual energy X-ray absorptiometry (DXA), and between these methods with food intake and history of bone fractures. Subjects and methods: After two years of follow up of 270 schoolchildren, 10 of them, who showed bone mass below -2 SD in QUS, were included in the present study. Laboratory results and DXA data were analyzed. Results: Bone mass evaluated by DXA at L1-L4 ranged from -2.8 to -1.1 SDS, and whole body bone mass, from -2.9 to -1.2 SDS. Three children had history of non-pathological bone fractures. Dietary assessment showed low intake of calcium in 10 cases, of phosphorus in 6, and of vitamin D in 8 cases. There were no differences among the cases of bone mass below -2 SD in any of the three used methods. There was no association between history of bone fractures and food intake, and between these evaluations and bone mass. Conclusion: In this small group of schoolchildren there was an association between the methods QUS and DXA. However, there was no association between bone mass and the history of bone fractures, or calcium, phosphorus and vitamin D intake. Arq Bras Endocrinol Metab. 2012;56(1):19-24

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Comparison of Quantitative Ultrasound Measurements in Calcaneus with DXA and SXA at Other Skeletal Sites: A Population-Based Study on 280 Children Aged 11-16 Years

Cited by 67 publications

References 27 publications

The relationship between paediatric calcaneal quantitative ultrasound measurements and dual energy X-ray absorptiometry (DXA) and DXA with laser (DXL) as well as body composition

The relationship between paediatric calcaneal quantitative ultrasound measurements and dual energy X-ray absorptiometry (DXA) and DXA with laser (DXL) as well as body composition

Quantitative Ultrasound Methods to Assess Bone Mineral Status in Children: Technical Characteristics, Performance, and Clinical Application

Comparação preliminar entre ultrassonografia quantitativa de falanges e densitometria óssea na avaliação da massa óssea em adolescentes

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