Comparison of Radiation Dose and Image Quality of Contrast-Enhanced Dual-Source CT of the Chest: Single-Versus Dual-Energy and Second-Versus Third-Generation Technology

Lenga, Lukas; Leithner, Doris; Peterke, Julia L; Albrecht, Moritz H.; Gudauskas, Tomas; D’Angelo, Tommaso; Booz, Christian; Hammerstingl, Renate; Vogl, Thomas J.; Martin, Simon S.; Wichmann, Julian L.

doi:10.2214/ajr.18.20065

Cited by 19 publications

(13 citation statements)

References 31 publications

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“…The result was similar to that from the study done by Lenga et al [23], which showed no significant difference in objective image quality in images obtained using SECT and DECT modes in a third-generation dualsource scanner. In another study done by Lenga et al [24], in the evaluation of chest CT, there were no statistically significant differences in CNR values of descending thoracic aorta, pulmonary trunk, and thyroid gland as well as the FOM value of the pulmonary trunk between SECT and DECT groups of a third-generation scanner.…”

Section: Evaluation Of Objective Image Qualitymentioning

confidence: 83%

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Does dual-energy abdominal computed tomography increase the radiation dose to patients: a prospective observational study

et al. 2021

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The aim of our study was to compare single-energy (SECT) and dual-energy (DECT) abdominal computed tomography (CT) examinations in matched patient cohorts regarding the differences in effective radiation dose (ERD) and image quality performed in a third-generation dual-source computed tomography (DSCT) scanner. Material and methods:Our study included 100 patients, who were divided randomly into 2 groups. The patients included in Group A were scanned by SECT, and Group B members were scanned by DECT. Volume CT dose index (CTDI vol ), dose length product (DLP), and ERD for venous phase acquisition were recorded in each patient and were normalised for 40 cm. Analyses were performed by using statistical software (SPSS version 20.0 for windows), and Bonferroni correction for multiple comparisons was applied for p-values and confidence intervals.Results: Average ERD based on DLP values normalised for 40 cm acquisition were obtained for both Group A and Group B. The mean ERD for Group A was 11.89 mSv, and for group B it was 6.87 mSv. There was a significant difference in these values between Group A and Group B as shown by a p-value of < 0.001. On subjective and objective analysis, there was no statistically significant difference in image quality between the 2 groups. Conclusions:The protocols in third-generation DSCT using dual-energy mode resulted in significant reductions in the effective radiation dose (by approximately 58%) compared to SECT in routine abdominal examination in matched cohorts. Therefore, the quantitative imaging potential of DECT can be utilised in needed patients with decreased radiation dose in third-generation DSCT.

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Section: Evaluation Of Objective Image Qualitymentioning

confidence: 83%

“…In another study done by Lenga et al . [ 24 ], in the evaluation of chest CT, there were no statistically significant differences in CNR values of descending thoracic aorta, pulmonary trunk, and thyroid gland as well as the FOM value of the pulmonary trunk between SECT and DECT groups of a third-generation scanner.…”

Section: Discussionmentioning

confidence: 98%

Does dual-energy abdominal computed tomography increase the radiation dose to patients: a prospective observational study

et al. 2021

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“…However, DECT algorithms work better when materials have high atomic numbers, because these are characterized by large differences in attenuation at different photon energies (i.e., iodine and calcium). At tube voltages used in clinical routine, it is possible to generate virtual unenhanced images by subtraction of iodine from contrast-enhanced DECT examinations or VNCa series by subtraction of calcium [5,15,20,24,25].…”

Section: Basic Principles Of Dectmentioning

confidence: 99%

“…1) Dual-source CT (DSCT) platforms, consisting of two x-ray tubes that generate two beams at different voltages installed at about 90°from each other, which have the advantage of high temporal resolution; although two x-ray sources are involved, the radiation dose administered to the patient is usually divided between the two, resulting in dose neutrality of second-and third-generation DSCT scanners compared with conventional CT [25,26]; 2) Single-source with sequential acquisition CT platforms, which consist of two scans acquired consecutively at different tube potentials followed by co-registration for post-processing, offering the advantage of a full field of view and the drawback of poor temporal resolution as the patient is scanned twice, with an increase of radiation dose; 3) Single-source twin-beam platforms, in which a twomaterial filter splits the x-ray beam into high-and low-energy spectra on the z-axis before it reaches the patient; 4) Single-source tube voltage switching CT platforms, in which the x-ray tube alternates high and low potentials several times within the same rotation, which have the advantage of a full field of view; 5) Dual-layer detector CT platforms, which involve a superficial and a deep layer within the same detector plate that simultaneously collect lowenergy data by the superficial layer, and high-energy data by the deep layer.…”

Section: Basic Principles Of Dectmentioning

confidence: 99%

Virtual non-calcium dual-energy CT: clinical applications

et al. 2021

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Dual-energy CT (DECT) has emerged into clinical routine as an imaging technique with unique postprocessing utilities that improve the evaluation of different body areas. The virtual non-calcium (VNCa) reconstruction algorithm has shown beneficial effects on the depiction of bone marrow pathologies such as bone marrow edema. Its main advantage is the ability to substantially increase the image contrast of structures that are usually covered with calcium mineral, such as calcified vessels or bone marrow, and to depict a large number of traumatic, inflammatory, infiltrative, and degenerative disorders affecting either the spine or the appendicular skeleton. Therefore, VNCa imaging represents another step forward for DECT to image conditions and disorders that usually require the use of more expensive and time-consuming techniques such as magnetic resonance imaging, positron emission tomography/CT, or bone scintigraphy. The aim of this review article is to explain the technical background of VNCa imaging, showcase its applicability in the different body regions, and provide an updated outlook on the clinical impact of this technique, which goes beyond the sole improvement in image quality.

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“…Thus, these detectors detect only the incoming photons but cannot provide specific information about the photons' energy. Therefore, to get the spectral information for the concentration estimation of two contrast agents, the sample needs to be scanned with two different spectra, for example, using fast kVp-switching 23 or dual-source CT 24 methods.…”

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confidence: 99%

Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health

Paakkari

Inkinen

Honkanen

et al. 2021

Sci Rep

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Photon-counting detector computed tomography (PCD-CT) is a modern spectral imaging technique utilizing photon-counting detectors (PCDs). PCDs detect individual photons and classify them into fixed energy bins, thus enabling energy selective imaging, contrary to energy integrating detectors that detects and sums the total energy from all photons during acquisition. The structure and composition of the articular cartilage cannot be detected with native CT imaging but can be assessed using contrast-enhancement. Spectral imaging allows simultaneous decomposition of multiple contrast agents, which can be used to target and highlight discrete cartilage properties. Here we report, for the first time, the use of PCD-CT to quantify a cationic iodinated CA4+ (targeting proteoglycans) and a non-ionic gadolinium-based gadoteridol (reflecting water content) contrast agents inside human osteochondral tissue (n = 53). We performed PCD-CT scanning at diffusion equilibrium and compared the results against reference data of biomechanical and optical density measurements, and Mankin scoring. PCD-CT enables simultaneous quantification of the two contrast agent concentrations inside cartilage and the results correlate with the structural and functional reference parameters. With improved soft tissue contrast and assessment of proteoglycan and water contents, PCD-CT with the dual contrast agent method is of potential use for the detection and monitoring of osteoarthritis.

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Comparison of Radiation Dose and Image Quality of Contrast-Enhanced Dual-Source CT of the Chest: Single-Versus Dual-Energy and Second-Versus Third-Generation Technology

Cited by 19 publications

References 31 publications

Does dual-energy abdominal computed tomography increase the radiation dose to patients: a prospective observational study

Does dual-energy abdominal computed tomography increase the radiation dose to patients: a prospective observational study

Virtual non-calcium dual-energy CT: clinical applications

Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health

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