Comparison of Red Cell and Whole Blood Volume as Performed Using Both Chromium-51–Tagged Red Cells and Iodine-125–Tagged Albumin and Using I-131–Tagged Albumin and Extrapolated Red Cell Volume

Dworkin, Howard J.; Premo, Mary; Dees, Stuart M.

doi:10.1097/maj.0b013e3180986276

Cited by 52 publications

(40 citation statements)

References 11 publications

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“…Volumes were calculated from the known dosage administered and the radioactivity concentration measured in the blood. An extensive description of these methods is described elsewhere [32]. {Owing to temporary federal withdrawal of 125 I, PV was directly measured in 18 study participants using the BVA-100 semi-automated system (Daxor) designed for measuring plasma 131 I-labelled human serum albumin.…”

Section: Blood Volume Testmentioning

confidence: 99%

Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function

et al. 2009

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The study examined whether deficits in cardiac output and blood volume in a CFS (chronic fatigue syndrome) cohort were present and linked to illness severity and sedentary lifestyle. Follow-up analyses assessed whether differences in cardiac output levels between CFS and control groups were corrected by controlling for cardiac contractility and TBV (total blood volume). The 146 participants were subdivided into two CFS groups based on symptom severity data, severe (n=30) and non-severe (n=26), and two healthy non-CFS control groups based on physical activity, sedentary (n=58) and non-sedentary (n=32). Controls were matched to CFS participants using age, gender, ethnicity and body mass. Echocardiographic measures indicated that the severe CFS participants had 10.2% lower cardiac volume (i.e. stroke index and end-diastolic volume) and 25.1% lower contractility (velocity of circumferential shortening corrected by heart rate) than the control groups. Dual tag blood volume assessments indicated that the CFS groups had lower TBV, PV (plasma volume) and RBCV (red blood cell volume) than control groups. Of the CFS subjects with a TBV deficit (i.e. > or = 8% below ideal levels), the mean+/-S.D. percentage deficit in TBV, PV and RBCV were -15.4+/-4.0, -13.2+/-5.0 and -19.1+/-6.3% respectively. Lower cardiac volume levels in CFS were substantially corrected by controlling for prevailing TBV deficits, but were not affected by controlling for cardiac contractility levels. Analyses indicated that the TBV deficit explained 91-94% of the group differences in cardiac volume indices. Group differences in cardiac structure were offsetting and, hence, no differences emerged for left ventricular mass index. Therefore the findings indicate that lower cardiac volume levels, displayed primarily by subjects with severe CFS, were not linked to diminished cardiac contractility levels, but were probably a consequence of a co-morbid hypovolaemic condition. Further study is needed to address the extent to which the cardiac and blood volume alterations in CFS have physiological and clinical significance.

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Section: Blood Volume Testmentioning

confidence: 99%

Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function

et al. 2009

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“…46,49 This technique has been validated against the technically difficult and time-intensive double-labeled technique of chromium-tagged red blood cells and plasma albumin 1 to 125 (considered the gold standard) with the comparator volumes being within 1% of one another. 50,51 Normal total BV by this technique is defined as measured volumes within ±8% of the expected normal volume for each individual patient and RBCM and PV as measured volumes within ±10% of expected normal volumes. This reflects ≈3 SDs from the expected normal value and assures that measured values lying beyond these parameters are not in a normal range for …”

Section: Assessment Of Congestion and Extracellular Fluid Volume Overmentioning

confidence: 99%

Fluid Volume Overload and Congestion in Heart Failure

Miller

2016

Circ: Heart Failure

210

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Abstract-Volume regulation, assessment, and management remain basic issues in patients with heart failure. The discussion presented here is directed at opening a reassessment of the pathophysiology of congestion in congestive heart failure and the methods by which we determine volume overload status. Peer-reviewed historical and contemporary literatures are reviewed. Volume overload and fluid congestion remain primary issues for patients with chronic heart failure. The pathophysiology is complex, and the simple concept of intravascular fluid accumulation is not adequate. The dynamics of interstitial and intravascular fluid compartment interactions and fluid redistribution from venous splanchnic beds to central pulmonary circulation need to be taken into account in strategies of volume management. Clinical bedside evaluations and right heart hemodynamic assessments can alert clinicians of changes in volume status, but only the quantitative measurement of total blood volume can help identify the heterogeneity in plasma volume and red blood cell mass that are features of volume overload in patients with chronic heart failure and help guide individualized, appropriate therapy-not all volume overload is the same. (Circ Heart Fail. 2016;9:e002922.

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“…To settle this question, Dworkin et al directly compared blood volume analysis results from double labeling with those from the BVA-100 (22). No significant difference was found between the semiautomated results and those from the gold standard test, and the authors concluded that the 2 studies were equivalent.…”

Section: Automation Comes To Blood Volume Analysismentioning

confidence: 99%

Blood Volume Analysis: A New Technique and New Clinical Interest Reinvigorate a Classic Study

Manzone¹,

Dam²,

Soltis³

et al. 2007

Journal of Nuclear Medicine Technology

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Blood volume studies using the indicator dilution technique and radioactive tracers have been performed in nuclear medicine departments for over 50 y. A nuclear medicine study is the gold standard for blood volume measurement, but the classic dualisotope blood volume study is time-consuming and can be prone to technical errors. Moreover, a lack of normal values and a rubric for interpretation made volume status measurement of limited interest to most clinicians other than some hematologists. A new semiautomated system for blood volume analysis is now available and provides highly accurate results for blood volume analysis within only 90 min. The availability of rapid, accurate blood volume analysis has brought about a surge of clinical interest in using blood volume data for clinical management. Blood volume analysis, long a low-volume nuclear medicine study all but abandoned in some laboratories, is poised to enter the clinical mainstream. This article will first present the fundamental principles of fluid balance and the clinical means of volume status assessment. We will then review the indicator dilution technique and how it is used in nuclear medicine blood volume studies. We will present an overview of the new semiautomated blood volume analysis technique, showing how the study is done, how it works, what results are provided, and how those results are interpreted. Finally, we will look at some of the emerging areas in which data from blood volume analysis can improve patient care. The reader will gain an understanding of the principles underlying blood volume assessment, know how current nuclear medicine blood volume analysis studies are performed, and appreciate their potential clinical impact.

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Comparison of Red Cell and Whole Blood Volume as Performed Using Both Chromium-51–Tagged Red Cells and Iodine-125–Tagged Albumin and Using I-131–Tagged Albumin and Extrapolated Red Cell Volume

Cited by 52 publications

References 11 publications

Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function

Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function

Fluid Volume Overload and Congestion in Heart Failure

Blood Volume Analysis: A New Technique and New Clinical Interest Reinvigorate a Classic Study

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