In the era of technology 4.0, a system is needed to support the development of a company, both in industry, education, and others to help solve problems. In this study, the authors used the Backpropagation Neural Network Algorithm in recognizing hyperthyroid disease patterns. In this study, in the recognition of hyperthyroid disease patterns. The author uses 11 data variables that will be trained using the back-propagation algorithm where the weighting is done randomly and the second data is trained using the backpropagation algorithm. In this study using Matlab application for processing. From the results of testing data derived from kaggle, namely hyperthyroid disease data above, we can see in the 2-2-1 architecture which shows that the target is reduced by the jst output that the SSE is 0.06571 which indicates that there is an increase in hyperthyroid disease activity in humans. From the data obtained, that the performance of artificial neural network calculations with the Backpropagation Algorithm is 86%. Can be seen by comparing the desired target with the prediction target.