Comparison of relative forced expiratory volume of one second with dynamic magnetic resonance imaging parameters in healthy subjects and patients with lung cancer

Abstract

Purpose: To assess relative forced expiratory volume in one second (FEV1/vital capacity (VC)) in healthy subjects and patients with a lung tumor using dynamic magnetic resonance imaging (dMRI) parameters. Materials and Methods:In 15 healthy volunteers and 31 patients with a non-small-cell lung carcinoma stage I (NSCLC I), diaphragmatic length change (LE1) and craniocaudal (CC) intrathoracic distance change within one second from maximal inspiration (DE1) were divided by total length change (LE total , DE total ) as a surrogate of spirometric FEV1/VC using a true fast imaging with steady-state precession (trueFISP) sequence (TE/TR ϭ 1.7/37.3 msec, temporal resolution ϭ 3 images/second). Influence of tumor localization was examined. Results:In healthy volunteers FEV1/VC showed a highly significant correlation with LE1/LE total and DE1/DE total (r Ͼ 0.9, P Ͻ 0.01). In stage IB tumor patients, comparing tumor-bearing with the non-tumor-bearing hemithorax, there was a significant difference in tumors of the middle (LE1/LE total ϭ 0.63 Ϯ 0.05 vs. 0.73 Ϯ 0.04, DE1/DE total ϭ 0.66 Ϯ 0.05 vs. 0.72 Ϯ 0.04; P Ͻ 0.05) and lower (P Ͻ 0.05) lung region. Stage IA tumor patients showed no significant differences with regard to healthy subjects.Conclusion: dMRI is a simple noninvasive method to locally determine LE1/LE total and DE1/DE total as a surrogate of FEV1/VC in volunteers and patients. Tumors of the middle and lower lung regions have a significant influence on these MRI parameters.

Therapy monitoring using dynamic MRI: Analysis of lung motion and intrathoracic tumor mobility before and after radiotherapy

“…The obvious dependence of lung motion and tumor mobility on tumor localization recently has been proposed to be due to reduced compliance of the tissue surrounding the tumor [17,[27][28][29]. Unfortunately, compliance itself still is not sufficiently locally quantifiable on the basis of imaging techniques.…”

Influence of the distribution of emphysema on diaphragmatic motion in patients with chronic obstructive pulmonary disease

“…[8][9][10] It has been reported that chest wall motion evaluated by MRI is a surrogate marker of pulmonary function tests (PFTs). 11,12 Previous studies using MRI showed fl attening of the diaphragm and its limited and/or paradoxical movement in COPD patients compared with normal subjects. 13,14 MRI can also detect the infl uence of a local lung tumor on chest wall motion.…”

“…13,14 MRI can also detect the infl uence of a local lung tumor on chest wall motion. 10,12 We postulated that MRI can visualize slight differences in chest wall motion between predominantly upper and lower emphysema.…”

Magnetic resonance-compatible-spirometry: principle, technical evaluation and application

“…Dynamic magnetic resonance imaging (dMRI) has been proven to be a reliable tool for visualisation and evaluation of local chest wall movement and respiratory mechanics in healthy volunteers [1][2][3] and patients with lung cancer [4].…”