1999
DOI: 10.1016/s0002-9149(98)00920-5
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Comparison of response to serotonin of radial artery grafts and internal mammary grafts to native coronary arteries and the effect of diltiazem

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Cited by 23 publications
(23 citation statements)
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“…Studies in patients have confirmed the observations of organ chamber studies showing an enhanced response of RA grafts to the intra-arterial infusion of 5-HT as compared with ITA grafts [15,16]; although the reasons for this hyper-reactivity are not fully understood, both the thick muscular media and the intrinsic biologic properties of the RA probably play a role. Both a1 and a2 receptors are abundantly present in the RA, as well as histamine 1, urotensin II, angiotensin I, ET, and calcitonin receptors [17][18][19][20][21][22], while b-adrenoceptors are less represented [23].…”
Section: Vasoreactivitymentioning
confidence: 55%
“…Studies in patients have confirmed the observations of organ chamber studies showing an enhanced response of RA grafts to the intra-arterial infusion of 5-HT as compared with ITA grafts [15,16]; although the reasons for this hyper-reactivity are not fully understood, both the thick muscular media and the intrinsic biologic properties of the RA probably play a role. Both a1 and a2 receptors are abundantly present in the RA, as well as histamine 1, urotensin II, angiotensin I, ET, and calcitonin receptors [17][18][19][20][21][22], while b-adrenoceptors are less represented [23].…”
Section: Vasoreactivitymentioning
confidence: 55%
“…The utilization of the left internal thoracic artery to the anterior intraventricular branch (with all its benefits) has already been proven [5][6][7], including its utilization in over 70-year-old patients. The use of arterial grafts has been the primary goal of all services, trying to reduce the reoperation and cardiovascular event rates [8,9,[11][12][13]. In spite of the great applicability of the saphenous graft, it is known that its evolution over the mid term and long term is unsatisfactory [6,11,14,15].…”
Section: Commentsmentioning
confidence: 99%
“…A artéria radial é especialmente suscetível a este fenômeno devido à grande musculatura lisa de sua parede, maior do que a da ATIE. A serotonina, um potente vasoconstritor, induz espasmo in vivo na radial mas não na ATIE (29) , o que demonstra a diferente atuação das camadas musculares dos dois vasos. A incidên-cia de vasoespasmo em enxertos de artéria radial gira em torno de 5 a 10% (16,30) .…”
Section: Manejo Do Vasoespasmounclassified
“…Os bloqueadores do cálcio, liderados pelo diltiazen, foram e ainda são as drogas empiricamente preconizadas para o controle do vasoespasmo no pós-operatório (14)(15)(16)18,(21)(22)(23) enquanto que no preparo trans-operatório a maioria dos Serviços utiliza a dilatação intraluminal com papaverina. Apesar da larga utilização, os trabalhos que estudaram a ação dos bloqueadores do cálcio no controle do vasoespasmo in vivo não mostraram benefício (29,30) . Em modelos experimentais para produção de espasmo em segmentos de radiais a partir de noradrenalina e KCl, diltiazen e verapamil não preveniriam o fenômeno enquanto que nifedipina foi eficaz contra a noradrenalina.…”
Section: Manejo Do Vasoespasmounclassified