Comparison of Retinal Nerve Fiber Layer Measurement Between 2 Spectral Domain OCT Instruments

Tan, Benjamin B.; Natividad, Maricel G.; Chua, Kia-Chong; Yip, Leonard W.

doi:10.1097/ijg.0b013e3182071cdd

Cited by 83 publications

(62 citation statements)

References 30 publications

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“…Using Spectralis ® in undilated pupils the average of TRV was 4.95, COV 1.7% and ICC 0.971 (11) . In our study the TRV was 4.85, COV 2.56% and ICC 0.944.…”

Section: Discussionmentioning

confidence: 99%

Reproducibility of peripapillary retinal nerve fiber layer thickness measurements using Spectral Domain OCT in Brazilian patients

Toscano¹,

Ávila²,

Chalita³

2012

Arq. Bras. Oftalmol.

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Purpose: To evaluate the reproducibility of peripapillary retinal nerve fiber layer (RNFL) thickness measurements in normal eyes and eyes with glaucoma using spectral domain optical coherence tomography (SDOCT). Methods: One eye of 79 normal and 72 glaucoma patients was analyzed. All patients underwent a complete ophthalmological examination, including visual acuity testing; intraocular pressure, slit-lamp examination, indirect ophthalmoscopy; and the glaucoma group underwent achromatic perimetry with the 24-2 SITA Fast Humphrey Field Analyzer. All patients' eyes were scanned using the spectral domain optical coherence tomography -Spectralis ® and one of them was cho sen randomly. Three con secutive circular B-scan centered at the optic disc were performed in one visit. Results: The intraclass correlation coefficient (ICC), coefficient of variation and test-retest variability for the mean retinal nerve fiber layer thickness were respectively: 0.94, 2.56% and 4.85 µm for the normal group and 0.93, 4.65% and 6.61 µm for the glaucomatous group. The intraclass correlation coefficient for retinal nerve fiber layer thickness in all quadrants were all excellent in both groups, with the superior quadrant having the highest ICCs (0.964) in glaucomatous eyes and nasal quadrant measurements having the lowest (0.800), but still excellent in eyes without glaucoma. The coefficient of variation was between 2.56% -8.74% and between 4.65% -11.44% in normal and glaucomatous group respectively. The test-retest variability was between 4.85 µm and 11.51 µm in the normal group and between 6.61 µm and 14.24 µm in the glaucomatous group. The measurements in glaucomatous eyes were more variable than normal eyes. Conclusions: Spectral domain optical coherence tomography showed excellent reproducibility with regard to retinal nerve fiber layer thickness measurements in normal and glaucomatous eyes.Keywords: Diagnostic techniques, ophthalmological; Glaucoma/diagnosis; Tomography, optical coherence/methods; Retinal ganglion cells; Optic nerve/pathology; Nerve fibers; Reproducibility of results RESUMO Objetivo: Avaliar a reprodutibilidade da medida da espessura da camada de fibras nervosas da retina (CFNR) em olhos sem e com glaucoma utilizando-se tomografia de coerência óptica de domínio espectral (spectral domain OCT -SDOCT

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“…Using Spectralis ® in undilated pupils the average of TRV was 4.95, COV 1.7% and ICC 0.971 (11) . In our study the TRV was 4.85, COV 2.56% and ICC 0.944.…”

Section: Discussionmentioning

confidence: 99%

Reproducibility of peripapillary retinal nerve fiber layer thickness measurements using Spectral Domain OCT in Brazilian patients

Toscano¹,

Ávila²,

Chalita³

2012

Arq. Bras. Oftalmol.

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“…25 RSLT kalınlığının OKT ile ölçüm tekniği, gü-venilir ve tekrarlanabilir olduğu değişik çalışma-larda da gösterilmiştir. [19][20][21] Bizim çalışmamızda da katarakt operasyonu sonrası RSLT kalınlık değişi-minin, ölçüm tekniğinden dolayı değil, fonksiyonel olduğunu düşünüyoruz. Optik sinir başının analizi için konfokal laser tarayıcı tomografi (HRT), laser tarayıcı polarimetri (GDx) gibi diğer yöntem-lerde kullanılabilir.…”

Section: Discussionunclassified

“…RSLT kalınlığı-nın ölçümünde, OKT tekniği güvenilir ve tekrarlanabilir olduğu gösterilmiştir. [19][20][21] İstatistiksel değerlendirmeler; ameliyat ön-cesi 1. gün ve ameliyat sonrası 1. gün ve 1. ayda OKT ile ölçülen, ortalama overall, superior ve inferior RSLT kalınlıklarının, glokomlu, glokomsuz ve iki grubun toplamında karşılaştırılması sureti ile yapıldı. Tüm istatistiksel çalışmalar 'SPSS 15.00 for Windows' (SPSS Inc., Chicago, İllinosis, ABD) yazılımı kullanılarak gerçekleştirildi.…”

Section: Gereç Ve Yöntemlerunclassified

The Effect of Cataract on Retina Nerve Fiber Layer Thickness in Eyes with or without Glaucoma Assessed by Optical Coherence Tomography

Unsal¹,

Acar²,

Öztürker³

et al. 2013

Turkiye Klinikleri J Med Sci

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“…The disparity in RNFL measurements between the Cirrus and Spectralis concurs with previous published data where the Spectralis generates thicker RNFL thickness readings. Some of the explanations that have been suggested for the disparate findings include differences in RNFL boundary segmentation algorithms, signal strength, scan acquisition, data processing and/or software properties between the two devices [20,21].…”

Section: Discussionmentioning

confidence: 99%

The Effects of PASCAL Panretinal Photocoagulation on the Peripapillary Retinal Nerve Fiber Layer

Mohla¹,

Mathur²

2016

J Clin Exp Ophthalmol

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Purpose: To investigate the effects of Pascal (Topcon Medical Laser Systems, Inc. Oakland, NJ) pan-retinal photocoagulation (PRP) on the optic nerve head (ONH).Method: This was a prospective case control study comparing 3 groups of patients seen in the diabetic retinopathy (DR) clinics, without any coexistent optic nerve pathology.Group A patients had proliferative or severe non proliferative DR necessitating PRP during the study period. Group B patients had mild or moderate DR and did not require PRP throughout the study period. Group C patients had standard retinal laser (green argon or frequency doubled YAG) PRP at least 2 years ago. All the 3 Groups had retinal oxygenation measurements and retinal vessel caliber readings by Oxymap T1(Oxymap, Reykjavik, Iceland), optic disc stereophotographs, high definition optical coherence tomography (HD-OCT) scans of the ONH by both Cirrus (Carl Zeiss Meditec Inc, Dublin, CA) and Spectralis (Heidelberg Engineering, Heidelberg Germany). These were performed prior to PRP at baseline, then at 3, 6, and 12 months post PRP for group A and at baseline, 3, 6, and 12 months for groups B and C. Paired t-test was used to assess the mean changes in parameters from baseline for each group.Results: A total of 90 patients were recruited including 27 in Group A, 31 in Group B and 32 in Group C. At baseline, the average retinal nerve fibre layer (RNFL) was significantly thicker in group A compared to group B (102.0 ± 16.8 vs. 89.5 ± 11.6 μm, p=0.001) and group C (88.6 ± 11.2 μm, p=0.001) respectively. At 3 months, Group A exhibited a significant increase in the Cirrus average RNFL thickness (5.60 ± 8.54 µ, p=0.003) when compared to baseline. At 6 months, the average RNFL reverted to baseline values (p=0.89), and remained stable at 12 months (p=0.85). There was no significant change noted in the average Cirrus RNFL thickness at 3 and 6 months in Group B. At 12 months, the average RNFL was significantly thinner compared to baseline (-6.68 ± 8.10; p=0.005). In Group C, the average RNFL remained stable from baseline through to month 12 (p>0.05 at the three timepoints). No significant changes were noted in the average Spectralis RNFL thickness at any timepoints in each of the three groups.Oxygen saturation dropped in all 3 groups at 3 months, being significant only in group B (-2.05 ± 4.20%, p=0.03). Conclusion:In eyes treated with Pascal PRP, there was an initial increase in the retinal nerve fibre layer at the optic nerve head at 3 months followed by a thinning back to baseline values at 6 months which then remained stable up to 12 months. Hence the Pascal PRP did not have a significant effect on the nerve fibre layer at 12 months.Keywords: Pascal panretinal photocoagulation; Optic nerve head; Retinal nerve fibre layer thickness; Retinal oximetry; Diabetic retinopathy SummaryIn this study, we investigated the effects of Pascal (Topcon Medical Laser Systems, Inc. Oakland, NJ) pan-retinal photocoagulation (PRP) on the optic nerve head (ONH). This was a prospective case control study c...

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Comparison of Retinal Nerve Fiber Layer Measurement Between 2 Spectral Domain OCT Instruments

Cited by 83 publications

References 30 publications

Reproducibility of peripapillary retinal nerve fiber layer thickness measurements using Spectral Domain OCT in Brazilian patients

Reproducibility of peripapillary retinal nerve fiber layer thickness measurements using Spectral Domain OCT in Brazilian patients

The Effect of Cataract on Retina Nerve Fiber Layer Thickness in Eyes with or without Glaucoma Assessed by Optical Coherence Tomography

The Effects of PASCAL Panretinal Photocoagulation on the Peripapillary Retinal Nerve Fiber Layer

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