Comparison of ribavirin degradation in the UV/H2O2 and UV/PDS systems: Reaction mechanism, operational parameter and toxicity evaluation

Jiang, Jinchan; An, Zexiu; Li, Mingxue; Huo, Yanru; Zhou, Yuxin; Xie, Ju; He, Maoxia

doi:10.1016/j.jece.2022.109193

Cited by 10 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have reported that some methoxyphenols and their degradation products (guaiacol, ribavirin, etc.) can be toxic to aquatic organisms when deposited into the aqueous environment [14,27]. Thus, it is necessary to assess the ecotoxicity of CA and its products to the aquatic environment.…”

Section: Introductionmentioning

confidence: 99%

Theoretical Study on the Mechanisms, Kinetics, and Toxicity Evaluation of OH-Initiated Atmospheric Oxidation Reactions of Coniferyl Alcohol

Zhang,

Wei,

Tang

2023

Atmosphere

View full text Add to dashboard Cite

In this paper, we investigated the mechanisms, kinetics, and toxicity evaluation of the OH-initiated reaction of coniferyl alcohol (4-(3-hydroxy-1-propenyl)-2-methoxyphenol) in the atmosphere using theoretical calculations. The initial reaction of coniferyl alcohol with OH radicals had two pathways, H-abstraction and OH-addition reactions. The total reaction rate constants were 2.32 × 10−9 cm3 molecule−1 s−1 (in gas-phase) and 9.44 × 109 s−1 M−1 (in liquid-phase) for the preliminary reactions of coniferyl alcohol with OH radicals at 298 K, respectively, and the half-lives of the total reaction (including all initial H-abstraction and OH-addition reactions) of coniferyl alcohol with OH radical in the atmosphere, urban and remote clouds were 8.3 × 10−2 h, 5.83 × 103 h and 9.27 × 102 h, respectively. The temperature had a strong and positive influence on the initial reaction rate constant. The branching ratios of H-abstraction and OH-addition reactions were 3.68% and 97.69%, respectively, making the OH-addition reactions become dominant reactions. The ecotoxicity evaluation revealed that the toxicity levels of coniferyl alcohol and its products were similar and non-toxic. However, all these products have developmental toxicity, with most of them having no mutagenicity. Therefore, further attention should be paid to the oxidation process and product toxicity evaluation of coniferyl alcohol in the atmosphere.

show abstract

Section: Introductionmentioning

confidence: 99%

Theoretical Study on the Mechanisms, Kinetics, and Toxicity Evaluation of OH-Initiated Atmospheric Oxidation Reactions of Coniferyl Alcohol

Zhang,

Wei,

Tang

2023

Atmosphere

View full text Add to dashboard Cite

show abstract

“…Nitrogen-containing heterocycles ((Nheterocycles) received considerable attention due to their significant therapeutic efficacy 4 . Heterocycles containing nitrogen and their synthetic analogs may produce new medications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Design of novel morpholinyl mannich bases for Potential Inhibitory Activity of SARS-CoV-2 Main Protease

Elamin

Almahmoud

Yousef³

et al. 2023

Orient. J. Chem

View full text Add to dashboard Cite

In this study, a new mannich base 1-(2H-1,3-benzodioxol-5-yl)-3-(morpholin-4-yl)propan-1-one (Mor) was successfully prepared in good yield. The structure of the title compound was elucidated by 1H-NMR, FT-IR, UV-Vis and electron-impact mass spectroscopy. The inhibitory activity of Mor against SARS-CoV-2 main protease (Mpro) was investigated by means of molecular docking approach. Mor showed excellent binding affinity to the active residues of Mpro with low binding score energy. Further improvements in the results were obtained by four designated analogues to Mor, characterized by the introduction of different methoxyl and hydroxyl substituents. The hydroxyl groups in Mor analogues significantly improve the binding affinity to the active site of Mpro to 56%, the binding energy to -6.3 kcal/mol, as well as the ability to form hydrogen bonds compared with nirmatrelvir as the reference Mpro inhibitor.

show abstract

Degradation and detoxification of ribavirin by UV/chlorine/Fe(II) process in water treatment system

Jiang,

He,

Zhang

et al. 2024

Environ Sci Pollut Res

View full text Add to dashboard Cite

Comparison of ribavirin degradation in the UV/H2O2 and UV/PDS systems: Reaction mechanism, operational parameter and toxicity evaluation

Cited by 10 publications

References 54 publications

Theoretical Study on the Mechanisms, Kinetics, and Toxicity Evaluation of OH-Initiated Atmospheric Oxidation Reactions of Coniferyl Alcohol

Theoretical Study on the Mechanisms, Kinetics, and Toxicity Evaluation of OH-Initiated Atmospheric Oxidation Reactions of Coniferyl Alcohol

Synthesis and Design of novel morpholinyl mannich bases for Potential Inhibitory Activity of SARS-CoV-2 Main Protease

Degradation and detoxification of ribavirin by UV/chlorine/Fe(II) process in water treatment system

Contact Info

Product

Resources

About