Comparison of royal college of pathologists and college of american pathologists definition for positive margins in oral cavity squamous cell carcinoma

Brinkman, David; Callanan, Deirdre; Jawad, Hadeel; O'Sullivan, Ryan; O’Shea, Ross; Dias, Andrew; Feeley, Linda; Sheahan, Patrick

doi:10.1016/j.oraloncology.2022.105797

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…5 However, positive margins are defined differently across guidelines, with the Royal College of Pathologists defining positive margins as including invasive cancer within 1 mm of the margin. 9 This discordance is further exemplified by a survey of American Head and Neck Society members, where only 46% of otolaryngologists defined clear margins as being ≥5 mm. 10 Although 5-mm has been most widely recognized as the threshold for clear margins, there have been limited empiric data to support this cutoff.…”

Section: Introductionmentioning

confidence: 99%

“…As per NCCN guidelines, a positive margin has been defined as malignant infiltration directly on the margin 5 . However, positive margins are defined differently across guidelines, with the Royal College of Pathologists defining positive margins as including invasive cancer within 1 mm of the margin 9 . This discordance is further exemplified by a survey of American Head and Neck Society members, where only 46% of otolaryngologists defined clear margins as being ≥5 mm 10 .…”

Section: Introductionmentioning

confidence: 99%

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Stratification of surgical margin distances by the millimeter on local recurrence in oral cavity cancer: A systematic review and meta‐analysis

et al. 2023

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There are limited data supporting the commonly suggested 5 mm margin cutoff as the optimum value in defining clear margins in oral cancer. A database search of Pubmed/Medline, Web of Science, and EBSCOhost was performed from inception to June 2022. A random‐effects model was chosen for this meta‐analysis. The Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) guidelines were followed throughout this study. Seven studies met study criteria (2215 patients). The risk ratio was significantly higher for margins <5 mm when compared to those ≥5 mm (2.09 (95%CI: 1.53–2.86, I2 = 0.47)). Subgroup analysis (I2 = 0.15) of margin distances of 0.0–0.9, 1.0–1.9, 2.0–2.9, 3.0–3.9, and 4.0–4.9 mm calculated risk ratios for local recurrence of 2.96, 2.01, 2.17, 1.8, and 0.98, respectively. Margins between 4.0 and 4.9 mm had similar risk ratios for local recurrence compared to ≥5 mm, while margins <4.0 were significantly higher.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stratification of surgical margin distances by the millimeter on local recurrence in oral cavity cancer: A systematic review and meta‐analysis

et al. 2023

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Impact of Close Margins on Oral Cancer Outcomes According to the Oral Subsite

Sheahan,

Callanan,

van den Berg

et al. 2024

Head & Neck

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BackgroundThe prognostic significance of close margins in oral squamous cell carcinoma (OSCC) is controversial. We wished to investigate the impact of close margins on the risk of local recurrence (LR) in OSCC according to the oral subsite.MethodsA retrospective cohort study of 342 OSCC patients undergoing primary surgical treatment was conducted. Surgical margins were based on the main specimen and defined as positive (SCC at margins), close (< 5 mm), or clear (≥ 5 mm).ResultsAmong tongue SCC cases, both positive (hazard ratio 13.48, 95% CI 2.03, 32.91) and close margins (hazard ratio 3.87, 95% CI 1.31, 11.34) were significantly associated with LR. Tongue margins < 4 mm were associated with higher LR. Among non‐tongue SCC cases, only positive margins (hazard ratio 4.10, 95% CI 1.19, 14.21) were associated with LR. Close margins were not significant (hazard ratio 1.59, 95% CI 0.46, 5.42).ConclusionsClose margins appear to have a differential impact on LR in OSCC according to the oral subsite.

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Should sub-millimeter margins be deemed positive in oral cavity squamous cell carcinoma?

Kang,

Lee,

et al. 2024

Oral Oncology

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Comparison of royal college of pathologists and college of american pathologists definition for positive margins in oral cavity squamous cell carcinoma

Cited by 7 publications

References 27 publications

Stratification of surgical margin distances by the millimeter on local recurrence in oral cavity cancer: A systematic review and meta‐analysis

Stratification of surgical margin distances by the millimeter on local recurrence in oral cavity cancer: A systematic review and meta‐analysis

Impact of Close Margins on Oral Cancer Outcomes According to the Oral Subsite

Should sub-millimeter margins be deemed positive in oral cavity squamous cell carcinoma?

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