Comparison of safety and efficacy of foam‐based versus solution‐based ciprofloxacin for acute otitis externa

Marom, Tal; Yelin, Rodrigo; Goldfarb, Alvin I.; Rakover, Yoseph; Shlizerman, Lev; Eilat, Eran; Roth, Yehudah

doi:10.1016/j.otohns.2010.06.819

Cited by 10 publications

(10 citation statements)

References 13 publications

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“…Similar results were ascertained in the studies that investigated a higher concentration of ciprofloxacin (0.3%) 14,16. In the study by Goldenberg et al14 about 77% of patients who were treated with ciprofloxacin fulfilled the definition of cure on Day 3–4.…”

Section: Background (Included Studies)supporting

confidence: 71%

“…The majority planned a 7-day application phase, during which the study participants applied three drops to each ear twice daily. Marom et al16 raised the dose to four drops (0.3% ciprofloxacin), and Goldenberg et al14 doubled the application period to 2 weeks. The exact dose remains unclear in the study by Drehobl et al13 in which the study period was also 7 days, with applications twice daily, but the study specified the dose as ampoule (“vial”) rather than stating the number of drops.…”

Section: Background (Included Studies)mentioning

confidence: 99%

“…An alternative approach to analyzing pain was chosen by Marom et al16 who, instead of the time to end of pain, evaluated the basic development of pain perception based on daily entries via the visual analog scale.…”

Section: Background (Included Studies)mentioning

confidence: 99%

“…Four studies specified such events additionally13,16,17,19 by explicitly analyzing medication-related adverse events; three studies evaluated clinical side effects/adverse events in general 12,14,18. Whether adverse events were of relevance in the study by Lildholdt et al remains unclear.…”

Section: Background (Included Studies)mentioning

confidence: 99%

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Treatment of acute otitis externa with ciprofloxacin otic 0.2% antibiotic ear solution

Mösges¹,

Nematian-Samani²,

Eichel³

2011

TCRM

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Background/objectiveAn inflammation of the cutis and subcutis of the external auditory canal is a primary symptom in cases of acute otitis externa. It is usually treated locally, since this type of therapy ensures a high concentration of the drug and interacts at the site of inflammation with no systemic effects. This systematic review compares the efficacy of treatment using a ciprofloxacin 0.2% solution with other therapeutic options.MethodsAfter compiling a catalog of search terms, medical databases were searched systematically for randomized, controlled studies. This search initially yielded a total of 38 studies which were then evaluated by three independent reviewers. The number of studies was subsequently reduced to 14: six studies using a ciprofloxacin 0.2% solution, and eight studies using both 0.2% and 0.3% solutions.ResultsThe studies included in the review demonstrate the statistical equivalence between the ciprofloxacin solution (0.2%) and the reference products PNH (a combination of polymyxin B, neomycin sulfate and hydrocortisone), auriculum powder, and a ciprofloxacin foam with respect to the cure rate. The research groups consistently observed high in vitro activity of ciprofloxacin against Pseudomonas aeruginosa.ConclusionThis systematic review confirms the hypothesis of ciprofloxacin’s noninferiority in the treatment of otitis externa, in terms of the cure rate and microbiological eradication.

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Section: Background (Included Studies)supporting

confidence: 71%

Section: Background (Included Studies)mentioning

confidence: 99%

Section: Background (Included Studies)mentioning

confidence: 99%

Section: Background (Included Studies)mentioning

confidence: 99%

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Treatment of acute otitis externa with ciprofloxacin otic 0.2% antibiotic ear solution

Mösges¹,

Nematian-Samani²,

Eichel³

2011

TCRM

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“…Foams are attractive vehicles to replace gels for vaginal and rectal delivery since foams offer convenient, single-step application while avoiding leakage of fluids that occurs with current formulations [2, 5]. Since foams provide coverage of large surface areas and access to difficult to reach areas, they have been used for nasal and auditory canal delivery [6, 7]. In these applications, the foam is made in the desired body cavity.…”

Section: Introductionmentioning

confidence: 99%

Responsive foams for nanoparticle delivery

Tang

Xiao

Sinko

et al. 2015

Colloids and Surfaces B: Biointerfaces

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We have developed responsive foam systems for nanoparticle delivery. The foams are easy to make, stable at room temperature, and can be engineered to break in response to temperature or moisture. Temperature-responsive foams are based on the phase transition of long chain alcohols and could be produced using medical grade nitrous oxide as a propellant. These temperature-sensitive foams could be used for polyacrylic acid (PAA)-based nanoparticle delivery. We also discuss moisture-responsive foams made with soap pump dispensers. Polyethylene glycol (PEG)-based nanoparticles or PMMA latex nanoparticles were loaded into Tween 20 foams and the particle size was not affected by the foam formulation or foam break. Using biocompatible detergents, we anticipate this will be a versatile and simple approach to producing foams for nanoparticle delivery with many potential pharmaceutical and personal care applications.

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Sensory Organs – Otologicals (S02)

Kutscher¹

2021

Ullmann's Encyclopedia of Industrial Chemistry

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Comparison of safety and efficacy of foam‐based versus solution‐based ciprofloxacin for acute otitis externa

Abstract: Foam-based ciprofloxacin is a safe and an effective new treatment for AOE.

Cited by 10 publications

References 13 publications

Treatment of acute otitis externa with ciprofloxacin otic 0.2% antibiotic ear solution

Treatment of acute otitis externa with ciprofloxacin otic 0.2% antibiotic ear solution

Responsive foams for nanoparticle delivery

Sensory Organs – Otologicals (S02)

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