Comparison of salivary cortisol, amylase, and chromogranin A diurnal profiles in healthy volunteers

Jantaratnotai, Nattinee; Rungnapapaisarn, Krittiphat; Ratanachamnong, Piyanee; Pachimsawat, Praewpat

doi:10.1016/j.archoralbio.2022.105516

Cited by 7 publications

(6 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For stress biomarkers, both sCort and sAA exhibited the diurnal patterns similar to previous studies 11 . The diurnal pattern of sCort went up with a peak at 30 min after awakening and declined throughout the day with the lowest levels at night time.…”

Section: Discussionsupporting

confidence: 82%

“…32 For stress biomarkers, both sCort and sAA exhibited the diurnal patterns similar to previous studies. 11 The diurnal pattern of sCort went up with a peak at 30 min after awakening and declined throughout the day with the lowest levels at night time. While the diurnal pattern of sAA had an opposite trend showing a trough level at 30 min after awakening and progressively increasing throughout the day.…”

Section: Discussionmentioning

confidence: 95%

“…Cortisol levels are high upon awakening and remain low as the day progresses while alpha‐amylase levels continuously increase as the day advances. 11 Under stressful conditions, both of these markers increased. They are the most studied biomarkers in the field of stress research since their levels have been reliably shown to be associated with stress; also, they can be conveniently detected in the saliva especially with real‐time measurement with alpha‐amylase.…”

Section: Introductionmentioning

confidence: 98%

“…They also exhibit a diurnal pattern of release throughout the day. Cortisol levels are high upon awakening and remain low as the day progresses while alpha‐amylase levels continuously increase as the day advances 11 . Under stressful conditions, both of these markers increased.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Exogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial

Pachimsawat,

Ratanachamnong,

Jantaratnotai

2024

Pharmacology Res & Perspec

Self Cite

View full text Add to dashboard Cite

This study aimed to examine the effect of acute exogenous melatonin administration on salivary cortisol and alpha‐amylase (sCort and sAA) as representatives of the HPA axis and the sympathetic nervous system, respectively. A single‐dose prolonged‐release melatonin (2 mg) or a placebo tablet was given to healthy volunteers (n = 64) at 20:00 h in a crossover design. The saliva was collected at six time points (20:00, 21:00, awakening, 30 min after awakening, 10:00, and 12:00 h) and was measured for sCort, sAA, and salivary melatonin (sMT) levels. Pulse rates and sleep parameters were also collected. Melatonin was effective in improving sleep onset latency by 7:04 min (p = .037) and increasing total sleep time by 24 min (p = .006). Participants with poor baseline sleep quality responded more strongly to melatonin than participants with normal baseline sleep quality as they reported more satisfaction in having adequate sleep (p = .017). Melatonin administration resulted in higher sCort levels at awakening time point (p = .023) and a tendency of lower sAA levels but these were not significant. Melatonin ingestion at 20:00 h resulted in a marked increase in sMT levels at 21:00 h and remained higher than baseline up to at least 10:00 h (p < .001). Melatonin increases sCort levels at certain time point with a tendency to lower sAA levels. These opposing effects of melatonin suggested a complex interplay between melatonin and these biomarkers. Also, the results confirmed the positive acute effect of a single‐dose melatonin on sleep quality.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Exogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial

Pachimsawat,

Ratanachamnong,

Jantaratnotai

2024

Pharmacology Res & Perspec

Self Cite

View full text Add to dashboard Cite

show abstract

“…An important advantage of salivary CgA determination, compared to the aforementioned salivary stress biomarkers, is that CgA levels are not affected by time of day [40]. Baseline chromogranin A concentration decreases with age [48]. Salivary CgA concentration responds quickly to changes in psychological tension [47].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Biological Treatment on Stress Parameters Determined in Saliva in Patients with Severe Psoriasis

et al. 2023

View full text Add to dashboard Cite

Background and objectives: In psoriatic patients, stress is the most common aggravating factor. Despite the use of quality-of-life assessment questionnaires, diagnosing stress in psoriatic patients is not a flawless procedure. This study aimed to assess the usefulness of potential stress biomarkers in saliva for monitoring the treatment of psoriasis. Materials and methods: A total of 104 adult patients with severe psoriasis were included and randomly treated via biological treatment or symptomatic therapy: 84 received biological treatment, with 20 formed a control group receiving symptomatic therapy. The administered biological treatment was adalimumab, whilst in controls calcipotriol/betamethasone dipropionate topical gel and emollients were used. Patients were monitored monthly with a dermatological examination and the dispensing of a biological drug. During each of the four visits, the severity of the disease was assessed (PASI, BSA, and DLQI), and a sample of the patient’s saliva was taken. In all the participants, the saliva concentrations of immunoglobulin A (sIgA), α-amylase (sAA), and chromogranin A (CgA) were measured. Results: The majority of patients in both the study and control groups achieved clinical improvement, though favoring the group receiving biological treatment. The concentration of sIgA in the saliva was constantly increasing in the study group during subsequent visits (Fr = 27.26; p < 0.001). Meanwhile, there were no statistically significant changes in the control group during the same follow-up period (Fr = 6.66; p = 0.084). Levels of sAA underwent statistically significant changes in both groups (Fr = 58.02; p < 0.001—study group and Fr = 13.74; p = 0.003—control group). In the study group, a steady, statistically significant increase in sAA was observed from the first to the third visit. In the study group, a downward trend in CgA concentration was observed. In the control group, no significant differences in the level of CgA were obtained. Conclusions: sIgA, sAA, and CgA are potential markers of the severity of psoriasis and the associated stress reaction. Based on the presented observations, only sIgA and CgA seem to be valuable biomarkers for monitoring the effectiveness of the systemic treatment of psoriasis.

show abstract

Psychological and Physiological Effects of Low-Level Meaningful Artificial Sounds on Intellectual Tasks

Asakura

2023

Acoust Aust

View full text Add to dashboard Cite

The present study aimed to investigate the psychological and physiological effects of low-level meaningful artificial sounds on intellectual tasks. The psychological factors related to the degree of disturbance, concentration, and stress, as measured by subjective evaluation, were compared with the degree of physiological stress, as measured using salivary alpha-amylase activity. The results indicated that human speech and chewing sounds caused similar levels of psychological stress while performing intellectual tasks; however, chewing sounds caused comparatively less physiological stress than did human speech sounds. These findings suggest that depending on the sound stimulus, psychological and physiological stress characteristics may not coincide.

show abstract

Comparison of salivary cortisol, amylase, and chromogranin A diurnal profiles in healthy volunteers

Cited by 7 publications

References 46 publications

Exogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial

Exogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial

The Effect of Biological Treatment on Stress Parameters Determined in Saliva in Patients with Severe Psoriasis

Psychological and Physiological Effects of Low-Level Meaningful Artificial Sounds on Intellectual Tasks

Contact Info

Product

Resources

About