The relationship between health literacy with health status and healthcare utilization ... [25] Examining the relation between health literacy and outcomes of diabetes in patients ... [26] Health literacy: cancer prevention ... [27] How does health literacy affect quality of life among men with newly ... [28] Mastectomy versus conservative surgical treatment: The impact on the quality ... [29] Quality of life in patients with breast cancer before and after diagnosis: An eighteen ... [30] Quality of life during the first year after breast cancer ... [31] Health-related quality of life of Kuwaiti women with breast cancer: A comparative study using the ... [32] Body image and self-steam: Comparison of two groups of Brest cancerous women ... [33] The Relationship of Body Image with Psychological Distress in Women ... [34] Body image and sexual problems in young ... [35] Mediators of the relationship between media literacy ... Aims The aim of this study was to investigate the relationship between health literacy and special quality of life and body image in women undergone mastectomy in reproductive age. Instruments & Methods This cross sectional descriptive-analytical study was conducted on 225 women in reproductive age (15-49) with breast cancer and having a mastectomy referred to Sina Hospital-breast surgery clinic, Breast Research Center, and Mahdieh Hospital from 2014 to 2015. A simple random sampling method as well as 4 questionnaires including the Health Literacy for the Iranian Adults (HELIA), Standard questionnaire of the European Organization for Research and Treatment of Cancer (EORTC version 3.0), special edition of Breast Cancer (QLQ-BR 23), and a Special questionnaire for body images was used. The data were analyzed by SPSS 21 software, using Spearman's correlation coefficient and one way ANOVA test. Findings There was a statistical significant relationship between job status, education, and health literacy of participants (p=0.001). The significant relationship was observed between health literacy and the overall quality of life (p=0.042). Fatigue and pain had the strongest impact on quality of life of patients. Also, there was a statistical significant relationship between the body image and education level. Conclusion Women's health literacy is closely related to their education level. There is a significant and positive relationship between the health literacy and overall quality of life. However, no statistical significant correlation is found between health literacy levels and symptom scales of breast cancer.