“…However, the limitations of sc-foaming are related to the complex modelling of the pore formation mechanisms to get a precise control and predictability of the pore sizes and distributions obtained for the processed scaffolds. Moreover, the use of depressurization gradients [ 18 ] and leaching methods with particulate porogens (e.g., NaCl, sucrose, carbonates, bicarbonates, zein [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]), and sacrificial polymers [ 27 ] within this foaming process can result in scaffolds with more open porosity and dual macroporosity (i.e., porous materials with two pore families in the macroporous range) [ 19 , 28 ]. The use of porogens is the most suitable approach to reach an additional macropore family with well-defined porosity and narrow pore size distribution, although an extra processing step will be usually needed to remove the porogen by solvent (usually water) leaching and the advantageous solvent-free property of sc-foaming technique is thus omitted [ 12 , 29 ].…”