Comparison of <scp>GEANT4</scp> very low energy cross section models with experimental data in water

Incerti, S.; Ivanchenko, A.; Karamitros, Mathieu; Mantero, A.; Moretto, Philippe; Tran, H.N.; Mascialino, B.; Champion, C.; Ivanchenko, V.; Bernal, Mario A.; Francis, Z.; Villagrasa, C.; Baldacchino, Gérard; Guèye, P.; Capra, R.; Nieminen, P.; Zacharatou, C.

doi:10.1118/1.3476457

Cited by 434 publications

(372 citation statements)

References 63 publications

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“…For the "Penelope Physics List" the applicability limit is 100 eV. In the framework of the Geant4-DNA project (Incerti et al 2010, Bernal et al 2015, an alternative "Physics List" is available for liquid water simulating the dominant physical interactions of electrons down to thermalization energy (~25 meV). For this study we combine either the "Livermore" or "Penelope" "Physics List" for the GNP with the Geant4-DNA "Physics List" for the surrounding water.…”

Section: Introductionmentioning

confidence: 99%

Geant4 interaction model comparison for dose deposition from gold nanoparticles under proton irradiation

Sotiropoulos

Taylor

Henthorn

et al. 2017

Biomed. Phys. Eng. Express

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Gold nanoparticles (GNPs) have shown a potential as a radiosensitizer in radiotherapy. The radiosensitization effect is thought to be linked to the increased dose deposition around the GNP. Monte Carlo simulations have been implemented for the calculation of the dose distributions around the GNPs and have been used for the calculation of the dose enhancement. They have also been imported to radiobiological models to predict biological endpoints. This work assessed the implications of different physical interaction models on the dose distribution and dose enhancement of GNPs surrounded by water under proton irradiation. The Penelope and Livermore physical interaction model implementation of the Geant4 simulation toolkit were compared considering the following parameters: i) GNP size, ii) proton energy, and iii) alternative physics model parameters in the gold or water medium. We found that neither the dose distribution nor the dose enhancement is sensitive to the model selection after the first 100 nm from the GNP surface. Within the first 100 nm the Livermore models calculated a higher dose, attributed to a higher production of low energy secondary electrons inside the GNP.

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Section: Introductionmentioning

confidence: 99%

Geant4 interaction model comparison for dose deposition from gold nanoparticles under proton irradiation

Sotiropoulos

Taylor

Henthorn

et al. 2017

Biomed. Phys. Eng. Express

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“…DPKs were calculated with the new set of models at low incident electron energies (100 eV and 1 keV) considering either the Geant4-DNA default models or the newly proposed models. At 100 eV, it was observed that the default Geant4-DNA models lead to a long-tail DPK caused by the too low electronic excitation cross section available by default in Geant4-DNA, as underlined in [32,48]. At 1 keV, a good agreement is observed between both sets of models.…”

Section: Dose Point Kernelsmentioning

confidence: 83%

“…Since 2007, Geant4-DNA offers physics processes and models able to describe particle interactions in liquid water at nanometre scale [31][32][33]. This Package currently provides a complete set of models describing the event-by-event electromagnetic interactions of particles (electrons, protons and neutral hydrogen atoms, alpha particles including their charge states) with liquid water (as well as ionisation for a few ions -Li, Be, B, C, N, O, Si and Fe).…”

Section: Physics Modellingmentioning

confidence: 99%

“…Interactions of protons, neutral hydrogen, neutral helium and charge states take into account ionisation, electronic excitation, electron loss or capture and elastic scattering; the corresponding models are described in detail in [32] and in all references cited therein. Low energy ionisation for protons is described using the semi-empirical approach proposed by Rudd et al (<500 keV) and it is based on the dielectric formalism above this energy, as proposed by Dingfelder et al [37].…”

Section: Physics Modellingmentioning

confidence: 99%

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Review of Geant4-DNA applications for micro and nanoscale simulations

et al. 2016

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Emerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-byevent electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis. Since its release, Geant4-DNA has been adopted as an investigational tool in kV and MV external beam radiotherapy, hadron therapies using protons and heavy ions, targeted therapies and radiobiology studies. It has been benchmarked with respect to other track structure Monte Carlo codes and, where available, against reference experimental measurements. While Geant4-DNA physics models and radiolysis modelling functionalities have already been described in detail in the literature, this review paper summarises and discusses a selection of representative papers with the aim of providing an overview of a) geometrical descriptions of biological targets down to the DNA size, and b) the full spectrum of current micro-and nano-scale applications of Geant4-DNA. Disciplines Engineering | Science and Technology Studies Publication DetailsIncerti, S., Douglass, M., Penfold, S., Guatelli, S. & Bezak, E. (2016). Review of Geant4-DNA applications for micro and nanoscale simulations. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 32 (10), 1187-1200. AbstractEmerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-by-event electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis.

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“…Geant4 is a general-purpose, open-source toolkit for the simulation of the passage of particles through matter that can, among other applications, also be used for track structure simulations by including the Geant4 Very Low Energy Extensions (Geant4-DNA) (Incerti et al, 2010).…”

Section: Interaction Cross Section Data In Ptra and Geant4-dnamentioning

confidence: 99%

Electron emission from amorphous solid water after proton impact: Benchmarking PTra and Geant4 track structure Monte Carlo simulations

Bug

Rabus

Rosenfeld

2012

Radiation Physics and Chemistry

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Track structure Monte Carlo simulations of ionising radiation in water are often used to estimate radiation damage to DNA. For this purpose, an accurate simulation of the transport of densely ionising low-energy secondary electrons is particularly important, but is impaired by a high uncertainty of the required physical interaction cross section data of liquid water.A possible tool for the verification of the secondary electron transport in a track structure simulation has been suggested by Toburen et al. (2010), who have measured the angle-dependent energy spectra of electrons, emitted from a thin layer of amorphous solid water (ASW) upon a passage of 6. MeV protons.In this work, simulations were performed for the setup of their experiment, using the PTB Track structure code (PTra) and Geant4-DNA. To enable electron transport below the ionisation threshold, additional excitation and dissociative attachment anion states were included in PTra and activated in Geant4. Additionally, a surface potential was considered in both simulations, such that the escape probability for an electron is dependent on its energy and impact angle at the ASW/vacuum interface.For vanishing surface potential, the simulated spectra are in good agreement with the measured spectra for energies above 50. eV. Below, the simulations overestimate the yield of electrons by a factor up to 4 (PTra) or 7 (Geant4-DNA), which is still a better agreement than obtained in previous simulations of this experimental situation. The agreement of the simulations with experimental data was significantly improved by using a steplike increase of the potential energy at the ASW surface. 2012 Elsevier Ltd. AbstractTrack structure Monte Carlo simulations of ionising radiation in water are often used to estimate radiation damage to DNA. For this purpose, an accurate simulation of the transport of densely ionising low-energy secondary electrons is particularly important, but is impaired by a high uncertainty of the required physical interaction cross section data of liquid water.A possible tool for the verification of the secondary electron transport in a track structure simulation has been suggested by Toburen et al. (2010), who have measured the angle-dependent energy spectra of electrons, emitted from a thin layer of amorphous solid water (ASW) upon a passage of 6 MeV protons.In this work, simulations were performed for the setup of their experiment, using the PTB Track structure code (PTra) and Geant4-DNA. To enable electron transport below the ionisation threshold, additional excitation and dissociative attachment anion states were included in PTra and activated in Geant4.Additionally, a surface potential was considered in both simulations, such that the escape probability for an electron is dependent on its energy and impact angle at the ASW/vacuum interface.For vanishing surface potential, the simulated spectra are in good agreement with the measured spectra for energies above 50 eV. Below, the simulations overestimate the yield of electrons by a ...

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Comparison of GEANT4 very low energy cross section models with experimental data in water

Cited by 434 publications

References 63 publications

Geant4 interaction model comparison for dose deposition from gold nanoparticles under proton irradiation

Geant4 interaction model comparison for dose deposition from gold nanoparticles under proton irradiation

Review of Geant4-DNA applications for micro and nanoscale simulations

Electron emission from amorphous solid water after proton impact: Benchmarking PTra and Geant4 track structure Monte Carlo simulations

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