Comparison ofHb‐200 and 6% hetastarch 450/0.7 during initial fluid resuscitation of 20 dogs with gastric dilatation‐volvulus

Abstract

Dogs with GDV receiving Hb-200 during initial resuscitation required smaller volumes of both crystalloid and colloid fluids and reached resuscitation end points faster than dogs receiving HES 450/0.7 (P = 0.02).

Cardiovascular and Systemic Effects of Gastric Dilatation and Volvulus in Dogs

“…In one study, 18 of 20 dogs (90%) had tachycardia (HR Z 120), and all dogs had abnormal perfusion parameters (mucus membranes, capillary refill time, and pulses). 15 Tachypnea, dyspnea, or both may be associated with discomfort and respiratory compromise as documented later.…”

Retrospective cohort study on the incidence of acute kidney injury and death following hydroxyethyl starch (HES 10% 250/0.5/5:1) administration in dogs (2007–2010)

“…Clinical use is widespread in small animal veterinary medicine; however, species‐specific clinical data are relatively sparse . The information available reports that HES is effective at increasing systolic blood pressure and oncotic pressure but also that HES use causes changes in coagulation function with decreased platelet function and reductions in coagulation factor VIII and von Willebrand factor activities . No published studies have evaluated the effects of HES on canine kidney function outside of the laboratory setting.…”

Hydroxyethyl starch: A review of pharmacokinetics, pharmacodynamics, current products, and potential clinical risks, benefits, and use

“…Several clinical studies of dogs and cats with SIRS‐related conditions that received 6% HES 450/0.75 have been reported. The dog studies used HES in dogs with naturally occurring gastric dilatation and volvulus and no adverse consequences from HES were reported . Haak et al administered HES as a bolus infusion with an isotonic crystalloid during resuscitation (mean of 18.4 mL/kg; range 10.5–37.3 mL/kg).…”

“…In addition, different conclusions are made with differing MS and concentration of the HES solution studied. The authors have used 6% HES 450(600)/0.75 in small animal patients for >30 years, and have published clinical studies reporting successful resuscitation of dogs and cats with the combination of 6% HES and isotonic balanced crystalloids as their primary means of fluid support ,. g,h The authors have also applied these techniques when using 6% HES 130/0.4.…”

“…Clinical studies in the dog and cat have reported that 6% hetastarch solutions are tolerated well by cats and dogs in the emergency and critical care setting. In 27 hypotensive cats, the combination of 6% HES 450/7.50 (2.5–18.5 mL/kg) with a buffered isotonic crystalloid (10–33 mL/kg) was efficacious at restoring normal or near normal systolic arterial blood pressure (SABP) with few adverse effects . In 16 hypotensive dogs, the combination of 6% HES 450/0.75 (6.88–31.25 mL/kg) with a buffered isotonic crystalloid (10–30 mL/kg) rapid infusion significantly improved SABP with no reported adverse effects .…”