Clothing is a mainstay of photoprotection and is commonly assessed by an ultraviolet protective factor (UPF) rating. We present original data on the increasing interest in photoprotective clothing as assessed by Google Trends and the frequency of UPF-rated clothing among a sample of Fortune 1000 companies. We review photoprotective clothing and occupational health, international standards governing UPF ratings, parameters of fabrics guiding UPF in clothing, synthetic and naturally occurring materials being explored for creating photoprotective clothing, and research in visible light and clothing photoprotection.Photoprotection is an important topic for the general public globally due to the ubiquitous presence of solar radiation. 1 Solar radiation that contributes to skin photodamage is primarily comprised of spectra in the ultraviolet radiation (UVR) range (280-400 nm), visible light (VL) range (400-700 nm), and possibly the infrared range (700-4000 nm). 2 Irradiation with UVB (280-320 nm) and to a lesser extent UVA (320-400 nm) result in DNA damage, erythema, and tanning. Chronic UVA and UVB radiation lead to photoaging and the development of keratinocyte carcinomas. 3-5 UVB exposure is well associated with melanoma. [6][7][8] A causal link between UVA and melanoma is less clear, with support in only some animal models and in epidemiological studies connecting tanning bed use and melanoma. 8-10 Globally, fair-skinned individuals constitute the majority of the estimated 6.4 million keratinocyte carcinomas and 300,000 malignant melanomas cases per year, which account for 62,000 deaths and 56,000 deaths per year, respectively. 11 In skin