Comparison of seed brachytherapy or external beam radiotherapy (70 Gy or 74 Gy) in 919 low-risk prostate cancer patients

Abstract

Low-risk prostate cancer patients receiving 74 Gy by EBRT show comparable biochemical control rates to patients receiving seed brachytherapy, whereas patients receiving 70 Gy show significantly worse outcome.

Brachytherapy Improves Biochemical Failure–Free Survival in Low- and Intermediate-Risk Prostate Cancer Compared With Conventionally Fractionated External Beam Radiation Therapy: A Propensity Score Matched Analysis

“…The rapid adoption of new RT practices as well as patient preference toward more convenient BT treatments are proposed explanations for the lack of comparative RT trials (13). A large number of retrospective studies have attempted to compare the treatment effectiveness of 2 or more RT modalities (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). However, interpretation of this retrospective evidence can be challenging because very few studies make direct comparisons in homogenous GUROC low-or intermediate-risk patient populations.…”

Permanent interstitial low-dose-rate brachytherapy for patients with low risk prostate cancer

“…We were, however, able to [26]. There is no doubt that large academic centers of excellence in Europe provide substantial clinical data [27]. As Kupelian et al [3] stated bRFS will "remain an important clinical endpoint even in the absence of data validating as it a surrogate for survival because of its use as a trigger for potentially curative salvage therapies or prolonged AD".…”

Clinical outcomes of 125I brachytherapy with and without external-beam radiation therapy for localized prostate cancer: results from 300 patients at a single institution in Japan

“…Several authors have reported that permanent implants for localized prostate cancer show excellent biochemical control and are associated with less severe toxicities [ 2 – 17 ]. According to a systematic review of randomized controlled studies, external-beam radiation therapy (EBRT), brachytherapy, and radical prostatectomy were found to be effective in the management of localized prostate cancer [ 18 ].…”