Comparison of selectivity of LDL removal by double filtration and dextran-sulfate cellulose column plasmapheresis, and changes of subfractionated plasma lipoproteins after plasmapheresis in heterozygous familial hypercholesterolemia

Therapeutic plasma exchange (TPE) has been used for the treatment of hyperlipidemic pancreatitis (HLP) with variable results. Eight patients with acute HLP were studied and treated with TPE, in addition to dietary fat restriction and lipid lowering agents. TPE lowered plasma levels of amylase (723.63 +/- 391.70-189.25 +/- 71.26 IU/L, P = 0.002), triglycerides (110.28 +/- 146.39-38.47 +/- 48.79 mmol/L, P = 0.048) and cholesterol (13.37 +/- 7.97-3.84 +/- 1.34 mmol/L, P < 0.001). Clinical symptoms improved in all patients with no resultant complications, and follow up of the patients for 12 months revealed no recurrence of pancreatitis. Thus, TPE is effective in lowering amylase, triglycerides and cholesterol levels, improves the acute attack of hyperlipidemic pancreatitis, and aids in preventing recurrent attacks.

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“…About two‐thirds of serum lipids are typically cleared by a single plasma exchange treatment (16). In a study by Yeh et al.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Plasma Exchange for Acute Hyperlipidemic Pancreatitis: A Case Series

2008

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“…Alternative extracorporeal techniques have been developed to improve LDL specificity and to lower cost. Removal of LDL can be accomplished with columns of heparin-agarose (7), dextran sulfate-cellulose (8), or antibody-agarose (9)(10)(11)(12) or by LDL precipitation at acidic pH (13). However, the limited capacity of the adsorbents makes these techniques cumbersome and very expensive.…”

mentioning

confidence: 99%

Enzymatic modification of plasma low density lipoproteins in rabbits: a potential treatment for hypercholesterolemia.

Labeque

Mullon

Ferreira

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

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Phospholipase A2 (EC 3.1.1.4) hydrolyzes certain phospholipids of low density lipoprotein (LDL). Plasma clearance of phospholipase A2-modified human LDL is up to 17 times faster than that of native human LDL in hypercholesterolemic rabbits. Modification of blood lipoproteins of hypercholesterolemic rabbits was performed by using an extracorporeal circuit containing immobilized phospholipase A2. After 90-min treatments, nearly 30% decreases in plasma cholesterol concentrations were observed. Erythrocyte, leukocyte, and platelet counts showed no net change after treatment. This technique does not require any fluid replacement or sorbent regeneration and offers a potential approach for lowering serum cholesterol and LDL levels.

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“…Also certain amounts of substitution solutions may be necessary. This treatment method therefore also has certain disadvantages in comparison to selective adsorbent techniques (13)(14)(15).…”

Section: Plasma Filtration Techniquesmentioning

confidence: 99%

“…LDL is selectively adsorbed by the polyanionic groups (13)(14)(15)(29)(30)(31)(32)(33). The use of two columns alternatively to increase the LDL-binding capacity of the system has been recently described (34).…”

Section: Ldl Adsorptionmentioning

confidence: 99%

Removal of Low Density Lipoproteins (LDL) from Plasma: The State of the Art

1989

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Comparison of selectivity of LDL removal by double filtration and dextran-sulfate cellulose column plasmapheresis, and changes of subfractionated plasma lipoproteins after plasmapheresis in heterozygous familial hypercholesterolemia

Cited by 39 publications

References 24 publications

Therapeutic Plasma Exchange for Acute Hyperlipidemic Pancreatitis: A Case Series

Therapeutic Plasma Exchange for Acute Hyperlipidemic Pancreatitis: A Case Series

Enzymatic modification of plasma low density lipoproteins in rabbits: a potential treatment for hypercholesterolemia.

Removal of Low Density Lipoproteins (LDL) from Plasma: The State of the Art

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