Comparison of Serum Cortisol and Testosterone Levels in Acute and Chronic Central Serous Chorioretinopathy

Natung, Tanie; Keditsu, Avonuo

doi:10.3341/kjo.2015.29.6.382

Cited by 14 publications

(15 citation statements)

References 31 publications

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“…14 On the contrary, some other studies had found no relation between increased cortisol level as well as serum testosterone level and chronic CSCR. 15,16 There exists controversy regarding the role of corticosteroids and the pathogenesis of CSCR. On one hand, steroids are said to strengthen the tight junctions and reduce bloodbrain and blood-retinal barrier breakdown, and also lowers permeability of vessels.…”

Section: Discussionmentioning

confidence: 99%

Endogenous Hypercortisolism in recurrent Central Serous Chorioretinopathy

Mukherji¹,

Karmakar²,

Dasgupta

2021

Asian J Med Sci

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Background: Central Serous Chorioretinopathy (CSCR) is an important cause of nonsurgical retinopathy leading to moderate to severe visual loss. Almost 50% cases undergo recurrence, and one of the recognizable risk factors is endogenous hypercortisolism. Aims and Objective: Our study intended to its presence in recurrent CSCR patients compared to non-chorioretinal disorder. Materials and Methods: Eighteen-month cross-sectional comparative study done on recurrent CSCR patients and matched refractive error patients comprised the comparison group. Use of exogenous steroids and diagnosed conditions of hypercortisolism were excluded. Sample size for both the groups was 34 in each. After taking history and performing ocular examination, blood samples for serum cortisol estimation collected in the morning and in the evening in patients of both the groups. Results analyzed using standard statistical methods. Results: All patients of recurrent CSCR were males. The mean serum levels of cortisol were higher than laboratory reference range during both times of the day in recurrent CSCR patients, and these levels were significantly higher than those in the comparison groups. Conclusion: Recurrent CSCR patients have higher level of endogenous cortisol compared to the non-chorioretinal patients, and its early recognition and management would certainly benefit the patients.

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Section: Discussionmentioning

confidence: 99%

Endogenous Hypercortisolism in recurrent Central Serous Chorioretinopathy

Mukherji¹,

Karmakar²,

Dasgupta

2021

Asian J Med Sci

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“…Previously, concentrations of steroid hormones, such as cortisol, aldosterone, and testosterone, have been widely investigated in patients with CSC; however, the findings have not been consistent, showing associations in some studies but not in others [6][7][8][9][10][11][12][13][14][15][16]. Serotonin (5-hydroxytryptamine (5-HT)), a neurotransmitter, influences many brain functions and plays important roles in the gastrointestinal system, blood, and brain, affecting behavior and physiology [17].…”

Section: Introductionmentioning

confidence: 99%

Central Serous Chorioretinopathy and Blood Serotonin Concentrations

Kondo

Araki

Komuku

et al. 2021

JCM

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Background: To investigate blood serotonin (5-hydroxytryptamine (5-HT)) concentrations and their relationships with selected characteristics in patients with central serous chorioretinopathy (CSC). Methods: This was a prospective study including 93 patients with active CSC. Blood concentrations of 5-HT, adrenocorticotropic hormone, and cortisol were measured in patients with CSC. Selected patient characteristics, including disease history (acute or chronic), medication use, smoking history, mood status, best-corrected visual acuity (BCVA), subfoveal choroidal thickness (SCT), findings on fluorescein and indocyanine green angiography, and anatomical changes were evaluated during follow-up. Results: Eleven of the 93 patients had low 5-HT concentrations (<57 ng/mL) (12%, eight men and three women; mean age 55 years); we identified no significant relationship with acute/chronic disease status. The patients with low 5-HT were significantly more likely to have five or more fluorescein leakage sites (p = 0.0275), recurrence of subretinal fluids (p < 0.0001), and failure to achieve significant improvement in BCVA during follow-up (p = 0.862) than patients with 5-HT within the normal range. Conclusions: Blood serotonin concentrations may influence the pathophysiology and prognosis of CSC.

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“…Serum levels of testosterone have not been shown to be elevated in CSCR. [4][5][6] However, there are case reports of exogenous testosterone use in association with CSCR in men and women. [7][8][9][10] Testosterone supplementation has become increasingly popular, despite some controversy regarding the risks and benefits.…”

Section: Introductionmentioning

confidence: 99%

Exogenous Testosterone Use and Central Serous Chorioretinopathy

Chen

Smith

2017

Journal of VitreoRetinal Diseases

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To investigate the clinical characteristics of central serous chorioretinopathy (CSCR) in the setting of exogenous testosterone use. Methods: Retrospective chart review of patients with a history of exogenous testosterone use and a diagnosis of CSCR at a large retina practice. Patient charts were reviewed for vision, clinical examination, and optical coherence tomography (OCT) results at each visit. Results: Four hundred eighty patients with a diagnosis of CSCR were identified, of which 7 patients had a history of exogenous testosterone use (1.46%). Of all, 0 of 7 patients reported any other steroid use. Ages ranged from 36 to 55 (mean, 46.57), and all were male. Only the right eye was involved in all 7 patients. Testosterone was discontinued in only 1 of the 7 patients. Six of the 7 patients had a visual acuity of 20/40 or better at last follow-up (range, 20/20-4/200). Three (43%) of the 7 had resolution of subretinal fluid at their last visit. The most common formulation of testosterone was for intramuscular injection. Conclusions: Exogenous testosterone use was reported in 1.46% of patients with CSCR compared to 0.8% in the general male population. The majority of patients in this study recovered 20/40 or better vision and 43% had resolution of subretinal fluid on OCT, suggesting a generally favorable prognosis for CSCR in the setting of testosterone supplementation.

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Comparison of Serum Cortisol and Testosterone Levels in Acute and Chronic Central Serous Chorioretinopathy

Cited by 14 publications

References 31 publications

Endogenous Hypercortisolism in recurrent Central Serous Chorioretinopathy

Endogenous Hypercortisolism in recurrent Central Serous Chorioretinopathy

Central Serous Chorioretinopathy and Blood Serotonin Concentrations

Exogenous Testosterone Use and Central Serous Chorioretinopathy

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