Comparison of serum cytokines between gestational diabetes mellitus and normal pregnancy women: a pilot study

Prediction of gestational diabetes mellitus: are we ready for a biomarker lead screening strategy for GDM?

“…Similarly, Argun et al [14] have shown significantly higher levels of endotrophin, a newly discovered adipocytokine, in second-trimester GDM subjects compared to those in normal pregnant women which correlated well with fasting and 1-h post-OGTT glucose values and HOMA-IR. Yang et al [15] from China demonstrated a low-grade inflammatory state in a small set of diagnosed GDM women who were shown to have significantly higher levels of IL2, IL6, and hsCRP than non-GDM pregnant women. While the findings of these studies point to possible pathogenetic links between inflammation, oxidative stress, and adipocytokines to GDM, they need to be confirmed in larger studies.…”