Comparison of Serum IgG Antibody Test with Gastric Biopsy for the Detection of Helicobacter Pylori Infection among Egyptian Children

Shady, Mones M. Abu; Fathy, Hanan A.; Ali, Alaa; Galal, Essam M.; Fathy, Gihan A.; Sibaii, Hiba

doi:10.3889/oamjms.2015.062

Cited by 12 publications

(12 citation statements)

References 22 publications

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“…The serologic test was positive in 60% of all cases. The sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for the IgG antibody (cutoff >10 U/mL,) were 96.5%, 93%, 13.83%, 0.038%, respectively …”

Section: Diagnosismentioning

confidence: 96%

Helicobacter pylori infection in children

2017

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Helicobacter pylori infection in children differs from that in adults, from the point of view of epidemiology, host response, clinical features, related diseases, and diagnosis, as well as treatment strategies. The prevalence of H. pylori infection, in both children and adults, is decreasing in the Western World as well as in some developing countries, which contrasts with the increase in childhood asthma and allergic diseases. Recurrent abdominal pain is not specific during H. pylori infection in children. The role of H. pylori infection and failure to thrive, children's growth, type I diabetes mellitus (T1DM) and celiac disease remains controversial. The main initial diagnosis is based on upper digestive endoscopy with biopsy-based methods. Nodular gastritis may be a pathognomonic endoscopic finding of childhood H. pylori infection. The infection eradication control is based on validated noninvasive tests. The main cause of treatment failure of H. pylori infection is its clarithromycin resistance. We recommend standard antibiotic susceptibility testing of H. pylori in pediatric patients prior to the initiation of eradication therapy. H. pylori treatment in children should be based on an evaluation of the rate of eradication in the local population, a systematic use of a treatment adapted to the susceptibility profile and a treatment compliance greater than 90%. The last meta-analysis in children did not show an advantage for sequential therapy when compared to a 14-day triple therapy. Finally, the high rate of antibiotic resistance responsible for therapy failure in recent years justifies the necessity of a novel vaccine to prevent H. pylori infection in children.

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Section: Diagnosismentioning

confidence: 96%

Helicobacter pylori infection in children

2017

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“…On the other hand, other recent studies have reported high accuracy of the serum antibody test in children. Previously conducted studies reported that the serum antibody test in children had a sensitivity and specificity in the range of 88.4–96.5 and 93.4–97.4%, respectively [31-33]. …”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Latex Agglutination Turbidimetric Immunoassay in Screening Adolescents for Helicobacter pylori Infection in Japan

et al. 2018

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Background/Aims: Serologic tests are commonly used for screening Helicobacter pylori infection because they not only provide quick results but also are inexpensive. A new latex agglutination serum antibody assay (LZ test) has been developed and it is expected to be as effective as conventional assays. This study aimed to calculate a reliable cutoff value for the LZ test and to estimate the sensitivity and specificity of the cutoff value in screening adolescents for H. pylori infection in Japan. Methods: We screened junior high school students in Akita Prefecture, Japan, for H. pylori infection. We used the data of 213 such students who underwent H. pylori stool antigen (HpSA) tests in 2016. The students who had positive results with HpSA tests were diagnosed with H. pylori infection. Of the 213 students, 209 underwent the LZ test. Results: The prevalence rate of H. pylori infection was 3.8% (8/209). The area under the curve for the LZ test was 0.88. The cutoff value of the LZ test was determined to be 3.1 U/mL. At this value, the sensitivity and specificity were 87.5 and 91.5%, respectively. Conclusion: The accuracy of the LZ test in adolescents was well balanced for sensitivity and specificity as well as for tolerable results.

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“…In addition, sensitivity is low in young children although still frequently used in epidemiological studies (Westblom et al 1992;Andersen et al 1994;Raymond et al 1996;Corvaglia et al 1999;Okuda et al 2002;Douraghi et al 2013). However, some recent publications suggest that newer serological tests are more reliable in children (Shady et al 2015;Kalach et al 2017;Raj et al 2017).…”

Section: Serologymentioning

confidence: 99%

Epidemiology, Diagnosis and Risk Factors of Helicobacter pylori Infection

Kotilea

Bontems

Touati

2019

Advances in Experimental Medicine and Biology

112

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Helicobacter pylori is a human-specific pathogen which leads to gastric pathologies including gastric cancer. It is a highly unique bacterium considered as a carcinogenic agent. H. pylori remains a major human health problem, responsible for ~90% of the gastric cancer cases. Approximately four billion individuals have been detected for H. pylori infection worldwide in 2015. At the turn of the 21 st century, the prevalence of H. pylori has been declining in highly industrialized countries of the Western world, whereas prevalence has plateaued at a high level in developing and newly industrialized countries. However, the infection status remains high in immigrants coming from countries with high prevalence of H. pylori infection. H. pylori can be diagnosed by invasive and non-invasive methods. Urea breath test and stool antigens detection are among the most commonly used non-invasive ones. Although the way H. pylori is transmitted remains still unclear, the level of contamination is strongly dependent on the familial and environmental context, with a drastic impact of living conditions with poor hygiene and sanitation. However, familial socioeconomic status is the main risk factor for H. pylori infection among children. In addition, food and water source have a high impact on the prevalence of H. pylori infection worldwide. This chapter highlights the latest knowledge in the epidemiology of H. pylori infection, its diagnosis and critical risk factors responsible for its high prevalence in some populations and geographic areas.

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Comparison of Serum IgG Antibody Test with Gastric Biopsy for the Detection of Helicobacter Pylori Infection among Egyptian Children

Cited by 12 publications

References 22 publications

Helicobacter pylori infection in children

Helicobacter pylori infection in children

Diagnostic Accuracy of Latex Agglutination Turbidimetric Immunoassay in Screening Adolescents for Helicobacter pylori Infection in Japan

Epidemiology, Diagnosis and Risk Factors of Helicobacter pylori Infection

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