Comparison of Serum Inhibin B and Follicle-Stimulating Hormone (FSH) Level between Normal and Infertile Men in Yaoundé

Corinne, Tchoula Mamiafo; Pieme, Constant Anatole; Jeanne, Ngogang

doi:10.1155/2020/4765809

Cited by 7 publications

(6 citation statements)

References 34 publications

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“…26 Supportive study was done by Mamiafo Corinne et al found a negative correlation between FSH and semen parameters in male partners of infertile couples. 27 A study conducted in 161 oligozoospermic men found normal level of LH and TST, but FSH levels show a negative association with sperm count which supports our findings. 28 Biswas et al found several fold higher concentrations of LH in seminal plasma when compare to serum and also found the concentration was lower in azoospermia compared to oligozoospermia and normozoospermia group.…”

Section: Discussionsupporting

confidence: 89%

Association of serum hormone profile and semen quality of infertile males in and around Chennai

Palani¹,

Jabbar

Jagannathan³

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: The infertility rate in India has also increased gradually along with population growth. Based on the geographic, the prevalence of male infertility varies. It is noticed that around the world 60–80 million couples with infertility problem every year. The aim of the study was to assess the correlation between the serum hormones and semen quality in infertile males.Methods: This research study was conducted in 60 infertile males aged from 20–50 years who reported at the Department of Andrology, Kanmani Fertility Centre (Pvt. Ltd.), Chennai, Tamil Nadu, India. The semen and hormone analysis was done in all study participants and its correlation was studied using SPSS (statistical product and service solutions) software.Results: The results demonstrate that among the study participants, 15.0% of them were normozoospermia, asthenozoospermia (26.6%), asthenoteratozoospermia (21.6%), oligoasthenozoospermia (16.6%) and oligoasthenoteratozoospermia (20.0) respectively. The results of Pearson correlation revealed that TSH, FSH, LH and PRL show a negative correlation but TST level shows a positive correlation with semen parameters.Conclusions: This study concludes that the serum hormones concentration was observed abnormal in infertile males which show negative correlation with semen parameters of the study participants.

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Section: Discussionsupporting

confidence: 89%

Association of serum hormone profile and semen quality of infertile males in and around Chennai

Palani¹,

Jabbar

Jagannathan³

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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“…On the other hand, MetS cases had a decrease of FSH, testosterone and inhibin B, while no significant difference was found in LH, estradiol, prolactin, and AMH. Previous studies reported a decrease of inhibin B and an increase of FSH in infertile males ( 37 ). However, our meta-analysis indicated a similar change trend of FSH and inhibin B in MetS.…”

Section: Discussionmentioning

confidence: 84%

Effects of Metabolic Syndrome on Semen Quality and Circulating Sex Hormones: A Systematic Review and Meta-Analysis

Zhao

Pang

2020

Front. Endocrinol.

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Previous studies were controversial in the effects of metabolic syndrome (MetS) on semen quality and circulating sex hormones, and thus we conducted a systematic review and meta-analysis to clarify the association. A systematic search was conducted in public databases to identify all relevant studies, and study-specific standardized mean differences (SMD) and 95% confidence intervals (CI) were pooled using a random-effects model. Finally, 11 studies were identified with a total of 1,731 MetS cases and 11,740 controls. Compared with the controls, MetS cases had a statistically significant decrease of sperm total count (SMD: −0.96, 95% CI: −1.58 to −0.31), sperm concentration (SMD: −1.13, 95% CI: −1.85 to −0.41), sperm normal morphology (SMD: −0.61, 95% CI: −1.01 to −0.21), sperm progressive motility (SMD: −0.58, 95% CI: −1.00 to −0.17), sperm vitality (SMD: −0.83, 95% CI: −1.11 to −0.54), circulating follicle-stimulating hormone (SMD: −0.87, 95% CI: −1.53 to −0.21), testosterone (SMD: −5.61, 95% CI: −10.90 to −0.31), and inhibin B (SMD: −2.42, 95% CI: −4.52 to −0.32), and a statistically significant increase of sperm DNA fragmentation (SMD: 0.76, 95% CI: 0.45 to 1.06) and mitochondrial membrane potential (SMD: 0.89, 95% CI: 0.49 to 1.28). No significant difference was found in semen volume, sperm total motility, circulating luteinizing hormone (LH), estradiol, prolactin and anti-Müllerian hormone (AMH) (P > 0.05). In conclusion, this meta-analysis demonstrated the effects of MetS on almost all the semen parameters and part of the circulating sex hormones, and MetS tended to be a risk factor for male infertility. Further larger-scale prospective designed studies were needed to confirm our findings.

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“…FSH plays an important role in spermatogenesis. Clinical studies reported that FSH levels were higher in infertile patients compared with fertile controls, and that FSH was negatively correlated to sperm concentration in the population surveyed ( 22 ). However, the relationship between FSH and sperm morphology has been rarely reported.…”

Section: Discussionmentioning

confidence: 99%

Influence of body mass index and waist–hip ratio on male semen parameters in infertile men in the real world: a retrospective study

Wang

et al. 2023

Front. Endocrinol.

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BackgroundIt is suggested that body mass index (BMI) can affect male semen quality; however, the results remain controversial. In addition, most studies have focused on the effect of obesity on semen quality. Evidence on the relationship of underweight or waist-hip ratio (WHR) with semen quality is rare. This study aimed to assess the association of BMI and WHR with semen quality.MethodsData, including BMI and WHR, was collected from 715.00 men who underwent a fertility evaluation. BMI (kg/m2) was categorized as <18.50 (underweight), 18.50–24.90 (normal), 25.00–27.90 (overweight), and ≥28.00 (obese) kg/m2 for analysis. WHR was categorized as <0.81 (normal) and ≥0.81 (high). Semen volume, sperm concentration, progressive motility, and total motile sperm count were detected by experienced clinical technicians.ResultsSpearman’s correlation showed that BMI was weakly associated with sperm progressive motility (r = 0.076, P < 0.05), while WHR showed no relationship with semen parameters. The azoospermia rate was significantly higher (33.33% vs. 2.10%, P < 0.001) and the sperm concentration was lower (P < 0.05) in the underweight group. The nonlinear correlation analysis showed that BMI was negatively associated with sperm concentration while BMI was more than 22.40 kg/m2 (P < 0.05), while WHR was negatively related to sperm progressive motility within 0.82 to 0.89 (P < 0.05). Furthermore, the multivariate logistic analysis showed that follicular stimulating hormone (FSH) was an independent risk factor for normal sperm concentration (odds ratio [OR]: 0.791, P = 0.001) and morphology (OR: 0.821, P = 0.002), BMI was an independent risk factor for normal sperm progressive motility, and testosterone was an independent risk factor for sperm morphology (OR: 0.908, P = 0.023).ConclusionBMI and WHR were significantly associated with semen parameters, while BMI was an independent risk factor for normal sperm progressive motility. Reproductive hormones, including FSH and testosterone, had a significant influence on sperm concentration and sperm morphology.

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Comparison of Serum Inhibin B and Follicle-Stimulating Hormone (FSH) Level between Normal and Infertile Men in Yaoundé

Cited by 7 publications

References 34 publications

Association of serum hormone profile and semen quality of infertile males in and around Chennai

Association of serum hormone profile and semen quality of infertile males in and around Chennai

Effects of Metabolic Syndrome on Semen Quality and Circulating Sex Hormones: A Systematic Review and Meta-Analysis

Influence of body mass index and waist–hip ratio on male semen parameters in infertile men in the real world: a retrospective study

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