Comparison of Serum Procalcitonin with Ranson, APACHE-II, Glasgow and Balthazar CT Severity Index Scores in Predicting Severity of Acute Pancreatitis

Woo, Su Mi; Noh, Myung Hwan; Kim, Byung Geun; Hsing, Chien Ter; Han, Ji‐Yeon; Ryu, Seung Hee; Seo, Jeong Min; Yoon, Hyun Ah; Jang, Jin Seok; Choi, Seok Reyol; Cho, Jin Han

doi:10.4166/kjg.2011.58.1.31

Cited by 43 publications

(44 citation statements)

References 27 publications

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“…A CRP level above 150 mg/L at 48 hours has a sensitivity and specificity of 80% and 76%, respectively, for predicting severe AP (15). A CRP cutoff level of 82 mg/L was studied in a Korean study, and the sensitivity, specificity and accuracy of CRP were reported to be 68.4%, 68%, and 68.2%, respectively (25). In our study, 150 mg/L was used as a CRP cutoff value.…”

Section: Discussionmentioning

confidence: 99%

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Can C-reactive protein levels increase the accuracy of the Ranson score in predicting the severity and prognosis of acute pancreatitis? A prospective cohort study

Başak

Hasbahçeci²,

Şişik³

et al. 2017

Turk J Gastroenterol

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Section: Discussionmentioning

confidence: 99%

“…The scarce availability of this test in laboratories is the main problem associated with this method (25,26). Another important acute phase reactant is CRP, and it has been studied in the literature for this aim.…”

Section: Discussionmentioning

confidence: 99%

Can C-reactive protein levels increase the accuracy of the Ranson score in predicting the severity and prognosis of acute pancreatitis? A prospective cohort study

Başak

Hasbahçeci²,

Şişik³

et al. 2017

Turk J Gastroenterol

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“…Currently, there is no specific biochemical parameter available to be used in the diagnosis and severity assessment of acute pancreatitis (14). Three hormones encoded by the ghrelin gene have been discovered in recent years, namely obestatin, de-acylated ghrelin, and acylated ghrelin, also known as bioactive peptides.…”

Section: Discussionmentioning

confidence: 99%

“…These systems may be stated as Ban's, Agarwal-Pitchumoni, Ranson, Glasgow (Imrie), and the acute physiology and chronic health evaluation (APACHE-II). However, these scoring systems are rather complex and difficult for use in clinical practice (5,6).…”

Section: Introductionmentioning

confidence: 99%

Significance of appetite hormone ghrelin and obestatin levels in the assessment of the severity of acute pancreatitis

Kanat¹,

Ayten²,

Aydın³

et al. 2014

Turk J Gastroenterol

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Background/Aims: Due to risk of morbidity and mortality, various tests and scoring systems used in the assessment of the diagnosis and severity of acute pancreatitis disease are gaining more importance every day. Most of the current scoring systems, validated by various parameters, have a sophisticated and complex structure. Research is ongoing to establish a method to diagnose the disease and determine the severity by using different and simple parameters. In this trial, we aimed to investigate the role of the orexigenic "ghrelin" and anorexigenic "obestatin" hormones, if any, on the diagnosis and assessment of the severity of acute pancreatitis. Materials and Methods: A total of 30 patients hospitalized between September 2009 and September 2010 with a diagnosis of acute pancreatitis (AP) and 25 healthy volunteers were enrolled in the trial with a prospective and randomized design. The patients were classified in two groups, mild (Ranson ≤3 and / or Apache II ≤8) and severe (Ranson >3 and/or Apache II >8) cases, as per the Ranson and Apache-II criteria; the ghrelin and obestatin levels in blood samples obtained from the patients were measured using the ELISA method. Results: Twenty-two of the 30 patients (73%) were regarded as mild pancreatitis cases, while 8 cases (27%) were diagnosed as severe pancreatitis. Comparison of the mild and severe pancreatitis groups did not reveal a statistical difference between the two groups in terms of acylated and de-acylated ghrelin values on presentation and following the initiation of oral feeding. Similarly, no significant difference was found in the comparison of the patient and the control groups in terms of acylated and de-acylated ghrelin values on presentation (p=0.863). On the other hand, acylated and de-acylated ghrelin values after initiation of oral feeding were observed to be higher in the patient group (p=0.001, p=0.000). Comparison of these two groups revealed a significant difference in obestatin values, both on presentation and after initiation of oral feeding (p=0.002 and p=0.000). Conclusion: Consistently high serum ghrelin values during pancreatic inflammation suggest that ghrelin may be used as an adjunctive parameter in the monitoring of the course of the disease. On the other hand, high obestatin values in patients on presentation indicate that this hormone is a more significant parameter in terms of diagnosis. However, no correlation was established between these two peptide hormones and the severity of AP.

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“…In this study, 21 patients (13%) were classified as severe AP, and two (10%) of these patients died during hospitalization. Some studies have reported that the cause of AP was not related to disease severity [15][16][17] . However, in this study, among the etiologies of AP, alcohol showed a significant association with patients with severe AP (P = 0.030).…”

Section: Discussionmentioning

confidence: 99%

Comparison of scoring systems in predicting severity of acute pancreatitis

Chung

Kim

2013

Pancreatology

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Comparison of Serum Procalcitonin with Ranson, APACHE-II, Glasgow and Balthazar CT Severity Index Scores in Predicting Severity of Acute Pancreatitis

Abstract: Serum PCT was a promising simple biomarker and had similar accuracy of APACHE-II scores as predicting severity of acute pancreatitis.

Cited by 43 publications

References 27 publications

Can C-reactive protein levels increase the accuracy of the Ranson score in predicting the severity and prognosis of acute pancreatitis? A prospective cohort study

Can C-reactive protein levels increase the accuracy of the Ranson score in predicting the severity and prognosis of acute pancreatitis? A prospective cohort study

Significance of appetite hormone ghrelin and obestatin levels in the assessment of the severity of acute pancreatitis

Comparison of scoring systems in predicting severity of acute pancreatitis

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