Comparison of Serum Vitamin D in the Umbilical Cord of Survived with Not Survived Premature Infants

Boskabadi, Hassan; Maamouri, Gholamali; Hemmatipour, Akram; Parvini, Zahra; Ramazani, Asal; Bagheri, Fariborz

doi:10.5812/ijp.84798

Cited by 8 publications

(8 citation statements)

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“…The results of a study showed vitamin D deficiency was more pronounced in newborns who died. Vitamin D deficiency may increase the likelihood of death of these infants by increasing respiratory problems and infections [7].…”

Section: Discussionmentioning

confidence: 99%

Comparison of vitamin D levels between mothers and infants with and without prolonged membrane rupture

Boskabadi

Rakhshanizadeh

Zakerihamidi

2022

Russian Journal of Infection and Immunity

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Background: Premature rupture of membranes is one of the known causes of preterm labor and accounts for approximately one-third of cases. Vitamin D deficiency may play a role in preterm labor, as well.Objective: The present study aimed to compare vitamin D levels in mothers and infants with and without prolonged rupture of membranes (PROM).Materials Methods: This cross-sectional study was performed on 241 babies with and without a history of rupture of membranes in mothers, in the neonatal ward of Ghaem Hospital, Mashhad from 2019 to 2021 with available sampling method. After the confirmation of prolonged rupture of membranes (more than 18 hours before birth) based on history and examination with a speculum, we completed data collection tool, a checklist including laboratory evaluation and neonatal and maternal characteristics. The condition of the neonates with and without prolonged rupture of membranes was compared. Data were analyzed by T-test and Chi-square.Results: We examined a total of 241 neonates including 148 (61.4%) without prolonged rupture of the membranes in mothers and 93 (38.6%) with PROM. There was a statistically significant difference between the two groups, maternal vitamin D level (P = 0.001), neonatal vitamin D level (P = 0.001), and fifth minute Apgar score (P = 0.003). This means that the values of these variables were lower in the group of neonates with PROM.Conclusion: Vitamin D deficiency in mothers has been significantly associated with prolonged rupture of membranes and with increasing severity of vitamin deficiency, the probability of PROM increases and therefore rises the likelihood of preterm labor and its complications.

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Section: Discussionmentioning

confidence: 99%

Comparison of vitamin D levels between mothers and infants with and without prolonged membrane rupture

Boskabadi

Rakhshanizadeh

Zakerihamidi

2022

Russian Journal of Infection and Immunity

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“…The incidence of vitamin D deficiency has been reported at 30% to 88% in infants as well as mothers worldwide. [20][21][22][23][24][25][26] In a study in Iran, 552 mothers and infants were examined for serum vitamin D levels and the results showed that 66% of the mothers and 93% of the newborns had vitamin D deficiency. 27 Our findings demonstrated a high prevalence of vitamin D deficiency among Iranian mothers and newborns, which is consistent with the mentioned study.…”

Section: Discussionmentioning

confidence: 99%

“…Levels less than 10 ng/mL were considered as severe, 10 to 20 ng/mL as moderate and 20 to 30 ng/mL as mild deficiency. 23 After collecting data and entering data into SPSS version 23, tables, figures, and statistical indices were used to analyze the results and evaluate the relationship between variables. For this purpose, after checking the normal distribution of data, Pearson's correlation coefficient and independent t test were used for normally distributed data.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Umbilical Cord Serum Vitamin D Levels between Infants with Transient Tachypnea of the Newborn and those without Respiratory Distress

et al. 2020

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Background: Transient tachypnea of the newborn (TTN) is one of the most frequent causes of respiratory distress in neonates. A relationship has been shown between vitamin D deficiency and respiratory disorders in neonates. This research was carried out to evaluate the serum level of vitamin D in TTN newborns and their mothers compared to the control group. Methods: This case-control research was conducted during 2016-2019 in a general hospital affiliated with Mashhad University of Medical Sciences, Iran. Thirty-four infants with TTN and 82 neonates in the control group as well as their mothers were investigated. The levels of umbilical cord serum vitamin D in infants with TTN and also their mothers were compared to the control group. Results: The mean levels of serum vitamin D in infants with TTN and their mothers were 8.11 ± 4.32 and 12.6 ± 10.12 ng/mL, respectively (P<0.001), whereas they were 19.21 ± 12.71 and 25.96 ± 16.6 ng/mL in the newborns of the control group and their mothers, respectively (P<0.001). The mean differences (95% CI) of neonatal and maternal vitamin D level between the two groups were 11.10 (7.92–14.28) and 13.36 (7.90–18.08), respectively. In the TTN group, 100% of the infants had vitamin D levels less than 30 ng/mL (79.4% had severe, 17.6% had moderate and 2.9% showed mild deficiency). However, vitamin D levels lower than 30 ng/mL were observed in 76.4% of the neonates in the control group (28.8% had severe, 31.1% showed moderate and 16.3% had a mild deficiency) (P<0.001). Conclusion: The serum vitamin D levels of infants with TTN and their mothers were significantly lower than the control group. Therefore, TTN in infants may be reduced through the treatment of vitamin D deficiency in mothers.

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“…This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. thy (21,22).…”

Section: Introductionmentioning

confidence: 99%

Correlation of Vitamin D Serum Level of Mothers and Their Newborns

Boskabadi

Heidari

2021

Mod Care J

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Background: The possibility of vitamin D deficiency is high among mothers and their premature newborns. Objectives: Due to the high rate of vitamin D deficiency in Iranian women, this study aimed to determine the association between the serum levels of vitamin D in the blood of premature newborns and their mothers in the Iranian population. Methods: This cross-sectional study was conducted on 324 mothers and their 324 newborns with gestational age less than 37 weeks, who were referred to Ghaem Hospital affiliated to Mashhad University of Medical Sciences, Mashhad, Iran, during 2016-2020. After clamping, 1.5 cc blood samples were obtained through the umbilical cord to determine the neonates’ vitamin D levels. Finally, the serum levels of vitamin D were measured, and the correlation between the levels of vitamin D of mothers and their newborns was calculated. Results: The mean vitamin D levels of newborns and mothers were 15.75 ± 11.18 and 20.16 ± 13.41 ng/mL, respectively. Moreover, there was a high correlation between the vitamin D levels of mothers and their newborns (r = 0.672; P < 0.001). Furthermore, a significant correlation was observed between the vitamin D levels of mothers, who used vitamin D supplementation during pregnancy and their neonates’ levels (r = 0.773; P < 0.001). Conclusions: The findings suggest a positive correlation between neonatal and maternal vitamin D levels. Moreover, it seems that maternal vitamin D levels can predict neonatal vitamin D deficiency.

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Comparison of Serum Vitamin D in the Umbilical Cord of Survived with Not Survived Premature Infants

Cited by 8 publications

References 30 publications

Comparison of vitamin D levels between mothers and infants with and without prolonged membrane rupture

Comparison of vitamin D levels between mothers and infants with and without prolonged membrane rupture

Comparison of Umbilical Cord Serum Vitamin D Levels between Infants with Transient Tachypnea of the Newborn and those without Respiratory Distress

Correlation of Vitamin D Serum Level of Mothers and Their Newborns

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