Comparison of short- and long-term treatment protocols and the results of second-line quadruple therapy in children with Helicobacter pylori infection

Abstract

The different duration of the two treatment regimens had no impact on eradication rates. Furthermore, quadruple therapy was necessary to achieve H. pylori eradication after triple therapy. However, the eradication rate with quadruple therapy was still insufficient. Consequently, a new therapeutic approach to H. pylori infection in children is needed.

A Triple and Quadruple Therapy with Doxycycline and Bismuth for First‐Line Treatment of Helicobacter pylori Infection: A Pilot Study

“…As second-and third-line therapy, a DOX quadruple regimen with PPI, amoxicillin, and bismuth salts was used for the treatment of H. pylori infection. In these studies, eradication rates were more satisfactory with values ranging between 66.3% and 90% of the treated case [38][39][40][41]. All the above-cited studies used DOX at the dose of 100 mg b.i.d.…”

Optimization strategies aimed to increase the efficacy of H. pylori eradication therapies

“…[30][31][32][33] However, there was no difference regarding the rate of side effects. 37,38 Accordingly, the Maastricht V Consensus Report stated that "the treatment duration of PPI-clarithromycin-based triple therapy should be extended to 14 days, unless shorter therapies are proven effective locally". 37,38 Accordingly, the Maastricht V Consensus Report stated that "the treatment duration of PPI-clarithromycin-based triple therapy should be extended to 14 days, unless shorter therapies are proven effective locally".…”

Helicobacter Pylori Therapy in Children: Overview and Challenges

“…The very limited experience in children with a quadruple regimen containing tetracyclines has yielded discrepant results. in terms of eradication rates (15,27). Furthermore, there is reluctance on the part of pediatricians to prescribe the tetracycline group of antibiotics.…”