To evaluate the clinical outcomes of laser in situ keratomileusis (LASIK) using a new approach for the calculation of the ablation profile based on wavefront vertexing from pupil plane to corneal.Methods: One hundred eyes of 50 patients (age, 21-41 years) with low and moderate myopia were enrolled in this prospective case series. All of them underwent topography-integrated wavefront-guided (TI-WFG) LASIK using the STAR S4IR excimer laser platform (Johnson & Johnson Vision). Visual, refractive, ocular aberrometric, ocular scattering index (OSI) and patient satisfaction outcomes were evaluated after a 90-day follow-up period. Astigmatic changes were evaluated by vector analysis.Results: A significant reduction in sphere and cylinder (p<0.001) was observed, with a significant improvement in uncorrected (UDVA) and corrected distance visual acuity (CDVA) (p<0.001). Postoperative spherical equivalent was within ±0.50 and Conclusions: TI-WFG LASIK is a new approach for myopia and myopic astigmatism correction, with preservation of the ocular optical quality and high level of patient satisfaction associated