Comparison of silver-coated dressing (Acticoat®), chlorhexidine acetate 0.5% (Bactigrass®) and nystatin for topical antifungal effect in Candida albicans-contaminated, full-skin-thickness rat burn wounds

Assessment of the Effectiveness of Silver-Coated Dressing, Chlorhexidine Acetate (0.5%), Citric Acid (3%), and Silver Sulfadiazine (1%) for Topical Antibacterial Effects Against the Multi-Drug Resistant Pseudomonas Aeruginosa Infecting Full-Skin Thickness Burn Wounds on Rats

“…Topical medications such as boric acid, acetic acid, 3% citric acid, 0.5% chlorhexidine acetate (Bactigrass), silver-coated dressing (Acticoat), and 1% silver sulfadiazine (Silverdin) have been used to treat burn wounds infected with Pseudomonas aeruginosa. [12][13][14][15][16]18,19,25,27 However, no study has compared the effectiveness of topical antimicrobial agents against multidrug-resistant Pseudomonas aeruginosa infections. Similarly, no experimental study has investigated the effectiveness of citric acid against Pseudomonas aeruginosa infections in burn patients.…”

“…When moistened with water, the nanocrystalline silver continues to release silver ions onto the wound surface. 13,14 These dressings have potent antibacterial activity against most of gram-negative and gram-positive bacteria, yeast, filamentous fungi, and viruses. 13,14 Citric acid has antiseptic property as indicated by microbiologic studies and by rapid clearing up of infected surfaces.…”

“…13,14 These dressings have potent antibacterial activity against most of gram-negative and gram-positive bacteria, yeast, filamentous fungi, and viruses. 13,14 Citric acid has antiseptic property as indicated by microbiologic studies and by rapid clearing up of infected surfaces. The use of citric acid as a topical agent for effective elimination of Pseudomonas aeruginosa from the burn wound has been reported.…”

“…Topical medications such as sulfamylon (mafenide acetate), silver nitrate, aquacel silver, Contreet antimicrobial foam, PolyMem Silver dressings, boric acid, acetic acid, 3% citric acid, 0.5% chlorhexidine acetate (Bactigrass), silver sulfadiazine 1% (Silverdin), and silver-coated dressing (Acticoat) are used clinically to treat Pseudomonas aeruginosa infections, which are frequently encountered in burn intensive care units and often lead to mortality. [12][13][14][15][16][17] Several topical and systemic antibacterial agents are used to treat infections in burn patients, and different drug groups produce distinct clinical responses. Most studies investigating such responses have examined topical agents individually.…”

Effectiveness of a novel topical powder on the treatment of traumatic oral ulcers in orthodontic patients: A randomized controlled trial

“…Nystatin decreases the inflammatory stimulus by reducing fungal colonization of wounds. 27 Dexamethasone and diphenhydramine, the anti-inflammatory and antihistamine components of the powder, also modulate the inflammatory response. 28,29 Metronidazole, another active component of the 2-DeNT powder, could also have accelerated ulcer healing.…”