Comparison of Single-Step Transepithelial Photorefractive Keratectomy With or Without Mitomycin C in Mild to Moderate Myopia

Adib-Moghaddam, Soheil; Soleyman-Jahi, Saeed; Tefagh, Ghazale; Tofighi, Salar; Grentzelos, Michael A.; Kymionis, George D.

doi:10.3928/1081597x-20180402-02

Cited by 19 publications

(26 citation statements)

References 37 publications

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“…None of the authors analyzing double-step TPRK reported predictability results. Among the authors who analyzed the single-step TPRK [ 24 , 27 , 28 , 29 , 30 ], they obtained predictable results comparable to those reported in our study. Our spherical equivalent refractive accuracy showed that 90% of eyes were in ±0.50 D and all eyes were in ±1.00 D. We found similar results in refractive astigmatism accuracy, 92% ≤ 0.50 D and 100% ≤ 1.00 D. Clinch et al [ 20 ] found comparable spherical accuracy results at three months follow-up with 74.4% of eyes within ±0.50 D and 93.5% of eyes ±1.00 D. Lee et al [ 21 ] reported worse results with only 56.9% of eyes within ±0.50 D or less.…”

Section: Discussionsupporting

confidence: 88%

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Plasma Rich in Growth Factors (PRGF) in Transepithelial Photorefractive Keratectomy (TPRK)

Sánchez‐González

Alonso-Aliste

Borroni

et al. 2021

JCM

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To evaluate the usage of plasma rich in growth factor (PRGF) in transepithelial photorefractive keratectomy (TPRK) in low and moderate myopia, patients who underwent myopic and astigmatism TPRK with PRGF were involved in this retrospective, observational study. Subjects underwent a surgical procedure between February 2019 and June 2019. A three-month follow-up was recorded. Pain score was assessed with a visual analogue scale (0–10) and re-epithelialization time recorded. A total of 48 eyes from 24 patients were recruited. Mean uncorrected distance visual acuity (UDVA) was 20/20.31 (0.00 ± 0.02 LogMAR). A total of 98% of eyes did not change corrected distance visual acuity (CDVA) lines. Two percent of eyes lost one line of CDVA. Preoperative spherical equivalent was −2.67 ± 1.37 D and after three months changed to −0.21 ± 0.34 D, and 2% of eyes changed 0.50 D or more between one and three months. Pain score was 3.29 ± 0.61 (3 to 6) score points at day one and 0.08 ± 0.27 score points at day seven. Finally, re-epithelialization time was 2.50 ± 1.20 days. PRGF addition to conventional refractive treatment such as TPRK seems to alleviate immediate postoperative pain and positively contribute to corneal re-epithelization time.

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Section: Discussionsupporting

confidence: 88%

“…Regarding predictability, our results obtained 1.03x + 0.29 (R 2 = 0.93). Overcorrection or undercorrection may occur during TPRK as well as other corneal surface refractive laser surgeries [ 21 , 27 , 28 ]. None of the authors analyzing double-step TPRK reported predictability results.…”

Section: Discussionmentioning

confidence: 99%

Plasma Rich in Growth Factors (PRGF) in Transepithelial Photorefractive Keratectomy (TPRK)

Sánchez‐González

Alonso-Aliste

Borroni

et al. 2021

JCM

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“…[ 15 ] The use of antimetabolites like MMC is widely used to prevent the haze formation because they are easy to prepare and very accessible for the prevention of corneal haze at a low cost. [ 5 , 16 , 17 ] The MMC can induce alterations in the count and morphology endothelial. [ 7 ] Furthermore, there is the possibility of systemic MMC diffusion into the bloodstream.…”

Section: Discussionmentioning

confidence: 99%

Plasma rich in growth factors versus Mitomycin C in photorefractive keratectomy

et al. 2021

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To evaluate the efficacy and safety of plasma rich in growth factors (PRGF) in photorefractive keratectomy (PRK) versus Mitomycin C (MMC). This is a comparative, longitudinal and retrospective case-control study (MMC vs PRGF), in patients with a spherical correction from −0.25 to −8.00 D and cylinder correction from −0.25 to −3.00. The uncorrected distance visual acuity (UDVA), refractive efficacy and safety indices, and changes in endothelial cell density were evaluated. The predictability was assessed with the postoperative manifest spherical equivalent. Forty-four patients (72 eyes) were treated with MMC and twenty-five patients (45 eyes) with PRGF. The final UDVA (LogMar) in MMC was 0.029 ± 0.065 and in PRGF it was 0.028 ± 0.048 (p = 0.383). The efficacy index for MMC was 0.98 ± 0.10 and 1.10 ± 0.46 for patients treated with PRGF (p = 0.062). The safety index for MMC was 1.03 ± 0.11 and 1.12 ± 0.46 (p = 0.158) for PRGF group. The change percentage of endothelial cell density was 0.9 ± 11.6 for MMC and 4.3 ± 13.1 for PRGF (p = 0.593). The predictability for MMC was 92.1% and for the PRGF was 91.9% (p = 0.976). Hyperemia, eye pain and superficial keratitis were observed in 11.1% of the MMC group; no adverse events were observed with the PRGF. The use of PRGF in PRK surgery is as effective as MMC. The PRGF shows a better safety profile than MMC for its intraoperative use in PRK.

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“…The use of mitomycin C demonstrated in previous studies an high and positive impact on the refractive results and in preventing haze formation post PRK [ 51, 52 ] although several reports showed the absence of significant differences in haze formation in patients with or without the use of mitomycin C during the follow‐up. [ 53, 54 ]…”

Section: Discussionmentioning

confidence: 99%

“…[50] The use of mitomycin C demonstrated in previous studies an high and positive impact on the refractive results and in preventing haze formation post PRK [51,52] although several reports showed the absence of significant differences in haze formation in patients with or without the use of mitomycin C during the follow-up. [53,54] In this study, it have been not used corticosteroids or mitomycin C in patients underwent PRK and subjects that presented haze consequent to PRK were excluded.…”

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confidence: 99%

Evaluation of corneal structures in myopic eyes more than twenty‐two years after photorefractive keratectomy

Montorio

Cennamo

Menna

et al. 2020

Journal of Biophotonics

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The aim of this study is to evaluate corneal epithelial thickness (CET), corneal densitometry (CD) in 84 myopic eyes (57 patients) more than 22 years after photorefractive keratectomy, using anterior segment-optical coherence tomography (AS-OCT) and Scheimpflug imaging system. The CET was significantly higher in all operated eyes than in unoperated eyes in central sector. A statistically significant increase in CD in corneal anterior layer of central sector was shown in groups of operated eyes with greater ablation depth respect to unoperated eyes. While there was no significant difference in CD between the operated eyes groups with lower ablation depth and unoperated eyes. A significant trend toward higher values in anterior CD with deeper ablations in central sector was found. These noninvasive imaging techniques allow to better understand the corneal remodeling process after photoablation and to monitor the patients over time.

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Comparison of Single-Step Transepithelial Photorefractive Keratectomy With or Without Mitomycin C in Mild to Moderate Myopia

Cited by 19 publications

References 37 publications

Plasma Rich in Growth Factors (PRGF) in Transepithelial Photorefractive Keratectomy (TPRK)

Plasma Rich in Growth Factors (PRGF) in Transepithelial Photorefractive Keratectomy (TPRK)

Plasma rich in growth factors versus Mitomycin C in photorefractive keratectomy

Evaluation of corneal structures in myopic eyes more than twenty‐two years after photorefractive keratectomy

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