Background: In the distal left main (LM) atherosclerosis mainly develops within bifurcation or trifurcation. The aim of this study was to analyze the strategy of distal LM stenosis treatment and associated clinical outcomes in a large (BiOSS 12.5% vs. rDES 9.6%). In logistic regression for 36-month TLR rate proximal optimization technique (OR 0.311,) was a prognostic factor of better clinical outcome, whereas non-ST-elevation ACS (OR 2.211,, MACE and TLR rates. (Cardiol J 2018; 25, 2: 188-195)