Comparison of skin traction, pressure, and rapid muscle release with conventional method on intramuscular injection pain: A randomized clinical trial

Background: The muscle relaxant methocarbamol is widely used for the treatment of muscle spasms and pain syndromes. To elucidate molecular mechanisms of its action, we studied its influence on neuromuscular transmission, on isometric muscle force, and on voltage-gated Na + channels. Methods: Neuromuscular transmission was investigated in murine diaphragm-phrenic nerve preparations and muscle force studied on mouse soleus muscles. Na v 1.4 channels and Na v 1.7 channels were functionally expressed in eukaryotic cell lines. Results: Methocarbamol, at 2 mM, decreased the decay of endplate currents, slowed the decay of endplate potentials and reduced tetanic force of soleus muscles. The drug reversibly inhibited current flow through muscular Na v 1.4 channels, while neuronal Na v 1.7 channels were unaffected. Conclusions: The study provides evidence for peripheral actions of methocarbamol on skeletal muscle. Muscular Na + channels are a molecular target of methocarbamol. Since Na v 1.7 currents were unaffected, methocarbamol is unlikely to exert its analgesic effect by directly blocking Na v 1.7 channels.

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Methocarbamol blocks muscular Na_v1.4 channels and decreases isometric force of mouse muscles

Zhang

Otto

Qin

et al. 2020

Muscle and Nerve

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The effects of vibration and pressure interventions on children's pain, fear and anxiety: A randomized controlled trial

Uzsen,

Tural Buyuk,

Odabasoglu

et al. 2024

Journal of Pediatric Nursing

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A New Approach on the pain management of intramuscular injection: A Triple-Blind Randomized Clinical Trial

Heshmatifar¹,

Salari²,

Rad³

et al. 2022

Pain Management Nursing

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Comparison of skin traction, pressure, and rapid muscle release with conventional method on intramuscular injection pain: A randomized clinical trial

Cited by 7 publications

References 18 publications

Methocarbamol blocks muscular Na_v1.4 channels and decreases isometric force of mouse muscles

Methocarbamol blocks muscular Na_v1.4 channels and decreases isometric force of mouse muscles

The effects of vibration and pressure interventions on children's pain, fear and anxiety: A randomized controlled trial

A New Approach on the pain management of intramuscular injection: A Triple-Blind Randomized Clinical Trial

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Comparison of skin traction, pressure, and rapid muscle release with conventional method on intramuscular injection pain: A randomized clinical trial

Cited by 7 publications

References 18 publications

Methocarbamol blocks muscular Nav1.4 channels and decreases isometric force of mouse muscles

Methocarbamol blocks muscular Nav1.4 channels and decreases isometric force of mouse muscles

The effects of vibration and pressure interventions on children's pain, fear and anxiety: A randomized controlled trial

A New Approach on the pain management of intramuscular injection: A Triple-Blind Randomized Clinical Trial

Contact Info

Product

Resources

About

Methocarbamol blocks muscular Na_v1.4 channels and decreases isometric force of mouse muscles

Methocarbamol blocks muscular Na_v1.4 channels and decreases isometric force of mouse muscles