Comparison of Small Bowel Lesions Using Capsule Endoscopy in Ulcerative Colitis and Crohn’s Disease: A Single-Center Retrospective Analysis

Ninomiya, Kazeo; Hisabe, Takashi; Okado, Yuki; Takada, Yasumichi; Yamaoka, Rino; Sato, Yuho; Kishi, Masahiro; Takatsu, Noritaka; Matsui, Toshiyuki; Ueki, Toshiharu; Yao, Kenshi; Hirai, Fumihito

doi:10.1159/000487796

Cited by 6 publications

(5 citation statements)

References 34 publications

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“… 72 reported that 36% of lesions of a patient with UC were detected in the SB, as well as 27.8% of patients also reported by Ninomiya et al. 73 We believe that the CE is also a useful device to identify injuries that could occur in the SB in patients with UC.…”

Section: Ce In CDsupporting

confidence: 55%

“…69 Oliva et al 70 reported a higher diagnostic accuracy of the CCE-2 during the evaluation of disease activity compared with CS in pediatric patients, also confirmed by Shi et al in a large-scale prospective study. 71 Interestingly, Hisabe et al 72 reported that 36% of lesions of a patient with UC were detected in the SB, as well as 27.8% of patients also reported by Ninomiya et al 73 We believe that the CE is also a useful device to identify injuries that could occur in the SB in patients with UC.…”

Section: Ce In Ucmentioning

confidence: 72%

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Video capsule endoscopy in inflammatory bowel disease

et al. 2021

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Since its introduction into clinical practice in 2000, capsule endoscopy (CE) has become an important procedure for many pathologies of small bowel (SB) diseases, including inflammatory bowel disease (IBD). Currently, the most commonly used capsule procedures are small bowel capsule endoscopy (SBCE), colon CE (CCE), and the recently developed pan‐enteric CE that evaluates the SB and colon in patients with Crohn's disease (CD). SBCE has a higher diagnostic performance compared to other radiological and conventional endoscopic modalities in patients with suspected CD. Additionally, CE plays an important role in monitoring the activity of CD in SB. It can also be used in evaluating response to anti‐inflammatory treatment and detecting recurrence in postsurgical patients with CD who underwent bowel resection. Due to its increasing use, different scoring systems have been developed specifically for IBD. The main target with CCE is ulcerative colitis (UC). The second‐generation colon capsule has shown high performance for the assessment of inflammation in patients with UC. CCE allows noninvasive evaluation of mucosal inflammation with a reduced volume of preparation for patients with UC.

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Section: Ce In CDsupporting

confidence: 55%

Section: Ce In Ucmentioning

confidence: 72%

Video capsule endoscopy in inflammatory bowel disease

et al. 2021

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“…[ 22 ] UC is restricted to the colon; however, a few cases of UC with gastroduodenal lesions and small bowel lesions have also recently been reported. [ 23 – 25 ] In our study, 180 patients were diagnosed with IBD (160 CD, 20 UC). In children with IBD, VCE can be used to investigate the parts of the small bowel that cannot be observed by gastroscopy and colonoscopy.…”

Section: Discussionmentioning

confidence: 99%

Clinical features of capsule endoscopy in 825 children

Huang

Wang

et al. 2020

Medicine

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Video capsule endoscopy (VCE) can detect mucosal lesions in the intestine, especially in the small bowel. Our study aims to evaluate the applications of VCE for pediatric gastrointestinal diseases. In this retrospective study, we included all patients who underwent VCE between December 2012 and December 2018. Clinical information and VCE data were analyzed. Among 828 patients, the completion rate was 99.6% (n = 825), with an average age of 10.2 ± 3.3 years old. A total of 459 VCE procedures showed abnormalities, and the overall diagnostic yield was 55.6%. The most common indications for VCE were abdominal pain among 505 (61.2%) patients and hematochezia (10.1%) among 83. Among the positive results of VCE, small bowel ulcers accounted for the highest percentage (57.7%), of which 164 cases were diagnosed as inflammatory bowel disease. For obscure gastrointestinal bleeding, 12 cases were diagnosed as Meckel's diverticulum. In terms of the small bowel transit time of VCE, compared with the negative group [288 (216.5, 390.3) min] and the enteritis group [277 (192.5, 374.8) min], a longer transit time was needed in the small bowel ulcer group [332.5 (240, 451.5) min, P < .01]. There were no correlations of positive VCE findings with anemia, the white blood cell count, the C-reactive protein level or the small bowel transit time according to Spearman rank analysis. VCE is relatively well tolerated and safe in children and has great value for the diagnosis and treatment of abdominal pain, especially inflammatory bowel disease and obscure gastrointestinal bleeding.

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“…We searched the PubMed and Embase databases using the terms "ulcerative colitis" and "post-colectomy enteritis" or "pan-enteritis" or "diffuse enteritis" or "pre-stomal enteritis" or "small bowel lesion" in English before June 1, 2020. Thirty-seven cases were previously reported [10][11][12][13][14][26][27][28][29][30][31][32]. This rare disease with distinct endoscopic inflammation of the stomach and small bowel resembles inflammation in the colon with UC.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Therapeutic Outcomes of Post-colectomy Enteritis with Ulcerative Colitis

Horio

Uchino

Hori

et al. 2021

J Anus Rectum Colon

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Objectives: Few reports are available on post-colectomy enteritis (PCE) with ulcerative colitis (UC), which can be severe and sometimes fatal. The clinical characteristics are unclear, and treatment and diagnosis protocols have not been established. We aimed to investigate the incidence, clinical characteristics, diagnostic criteria, and therapeutic outcomes of PCE in this study. Methods: Patients with UC who underwent colectomy between April 2010 and December 2019 were included in this study. We retrospectively analyzed patients who developed PCE and excluded patients with other forms of enteritis. Results: We performed 829 colectomies because of a preoperative diagnosis of UC. Eleven and four patients were diagnosed with Crohn's disease and indeterminate colitis after surgery, respectively; 22 patients developed enteritis in the perioperative period. We excluded six patients with backwash ileitis, five with prepouch ileitis, three with infectious enteritis, and one with ischemic enteritis. In total, 7/814 (0.8%) patients developed PCE. All patients with PCE had pancolitis. PCE was observed a median of 33 (12-248) days after surgery. Endoscopy showed friable and granular mucosa. The extent of disease included various types such as pan-enteritis with diffuse type, pan-enteritis and mild inflammation in the middle ileum, and only ileitis. Gastroduodenitis-associated UC developed in 6/7 cases. All patients improved with tumor necrosis factor alpha (TNFα) antagonists even if TNFα antagonists had not been effective for colitis. Conclusions: PCE was rare. The mucosal endoscopic findings were similar to those of UC, and the extent of disease varied. TNFα antagonist administration for PCE was effective.

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Comparison of Small Bowel Lesions Using Capsule Endoscopy in Ulcerative Colitis and Crohn’s Disease: A Single-Center Retrospective Analysis

Cited by 6 publications

References 34 publications

Video capsule endoscopy in inflammatory bowel disease

Video capsule endoscopy in inflammatory bowel disease

Clinical features of capsule endoscopy in 825 children

Clinical Features and Therapeutic Outcomes of Post-colectomy Enteritis with Ulcerative Colitis

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