Comparison of standard and immune‐enhancing oral formulas in asymptomatic HIV‐infected persons: a multicenter randomized controlled clinical trial

Keithley, Joyce K.; Swanson, Barbara; Zeller, Janice M.; Sha, Beverly E.; Cohen, Mardge H.; Hershow, Ronald C.; Novak, Richard

doi:10.1177/014860710202600106

Cited by 27 publications

(13 citation statements)

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“…This is consistent with the findings of weight and BMI gains from a corn-soy supplementation trial in Malawi [17] and a food assistance program in Haiti [18], but stands in contrast to studies in Europe [26] and the USA [27], [28] that did not find significant effects of macronutrient supplementation on BMI or weight gain [11], [16].…”

Section: Discussionsupporting

confidence: 89%

Descriptive Characteristics and Health Outcomes of the Food by Prescription Nutrition Supplementation Program for Adults Living with HIV in Nyanza Province, Kenya

et al. 2014

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BackgroundThe clinical effects and potential benefits of nutrition supplementation interventions for persons living with HIV remain largely unreported, despite awareness of the multifaceted relationship between HIV infection and nutrition. We therefore examined descriptive characteristics and nutritional outcomes of the Food by Prescription (FBP) nutrition supplementation program in Nyanza Province, Kenya.MethodsDemographic, health, and anthropometric data were gathered from a retrospective cohort of 1,017 non-pregnant adult patients who enrolled into the FBP program at a Family AIDS Care and Education Services (FACES) site in Nyanza Province between July 2009 and July 2011. Our primary outcome was FBP treatment success defined as attainment of BMI>20, and we used Cox proportional hazards to assess socio-demographic and clinical correlates of FBP treatment success.ResultsMean body mass index was 16.4 upon enrollment into the FBP program. On average, FBP clients gained 2.01 kg in weight and 0.73 kg/m2 in BMI over follow-up (mean 100 days), with the greatest gains among the most severely undernourished (BMI <16) clients (p<0.001). Only 13.1% of clients attained a BMI>20, though 44.5% achieved a BMI increase ≥0.5. Greater BMI at baseline, younger age, male gender, and not requiring highly active antiretroviral therapy (HAART) were associated with a higher rate of attainment of BMI>20.ConclusionThis study reports significant gains in weight and BMI among patients enrolled in the FBP program, though only a minority of patients achieved stated programmatic goals of BMI>20. Future research should include well-designed prospective studies that examine retention, exit reasons, mortality outcomes, and long-term sustainability of nutrition supplementation programs for persons living with HIV.

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Section: Discussionsupporting

confidence: 89%

Descriptive Characteristics and Health Outcomes of the Food by Prescription Nutrition Supplementation Program for Adults Living with HIV in Nyanza Province, Kenya

et al. 2014

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“…This was reported by Doherty et al when they assessed the acceptability of the free formula being provided nationally in South Africa [40]. However other studies, one in an HIV infected population and another where the HIV status was unknown found supplements to be acceptable [41,42]. A Mexican study found the acceptability of supplements to be poor due to the taste, the women preferred the tablets [43].…”

Section: Discussionmentioning

confidence: 91%

Effect of nutritional supplementation of breastfeeding HIV positive mothers on maternal and child health: findings from a randomized controlled clinical trial

2011

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BackgroundIt has been well established that breastfeeding is beneficial for child health, however there has been debate regarding the effect of lactation on maternal health in the presence of HIV infection and the need for nutritional supplementation in HIV positive lactating mothers.AimsTo assess the effect of nutritional supplementation to HIV infected lactating mothers on nutritional and health status of mothers and their infants.MethodsA randomized controlled clinical trial to study the impact of nutritional supplementation on breastfeeding mothers. Measurements included anthropometry; body composition indicators; CD4 count, haemoglobin and albumin; as well as incidence rates of opportunistic infections; depression and quality of life scores. Infant measurements included anthropometry, development and rates of infections.ResultsThe supplement made no significant impact on any maternal or infant outcomes. However in the small group of mothers with low BMI, the intake of supplement was significantly associated with preventing loss of lean body mass (1.32 kg vs. 3.17 kg; p = 0.026). There was no significant impact of supplementation on the infants.ConclusionsA 50 g daily nutritional supplement to breastfeeding mothers had no or limited effect on mother and child health outcomes.Clinical trial registrationISRCTN68128332 (http://www.controlled-trials.com/ISRCTN68128332)

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“…The Zambian evaluation also reported a significant increase in mid-upper arm circumference (MUAC) [23]. Several clinical trials have also shown that food supplementation with or without nutrition counselling reduced weight loss and improved weight gain [24][25][26][27]. In a Malawian study, ready-to-use therapeutic food (RUFT) improved weight-for-height of HIV-positive children [27].…”

Section: Nutrition Interventions In the Context Of Hivmentioning

confidence: 99%

Too little, too late: Comparison of nutritional status and quality of life of nutrition care and support recipient and non-recipients among HIV-positive adults in KwaZulu-Natal, South Africa

Oketch¹,

Paterson²,

Maunder³

et al. 2011

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Comparison of standard and immune‐enhancing oral formulas in asymptomatic HIV‐infected persons: a multicenter randomized controlled clinical trial

Abstract: Within the context and limitations of this study, standard and immune-enhancing oral formulas consumed daily for 1 year had no differential effects on nutrition or immune parameters in asymptomatic HIV-infected persons.

Cited by 27 publications

References 15 publications

Descriptive Characteristics and Health Outcomes of the Food by Prescription Nutrition Supplementation Program for Adults Living with HIV in Nyanza Province, Kenya

Descriptive Characteristics and Health Outcomes of the Food by Prescription Nutrition Supplementation Program for Adults Living with HIV in Nyanza Province, Kenya

Effect of nutritional supplementation of breastfeeding HIV positive mothers on maternal and child health: findings from a randomized controlled clinical trial

Too little, too late: Comparison of nutritional status and quality of life of nutrition care and support recipient and non-recipients among HIV-positive adults in KwaZulu-Natal, South Africa

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