The axial compressive performance of steel-reinforced concrete columns with monosymmetric cross-shaped steel (SRCC-MCS) was investigated in this study. Tests were conducted under pure axial compression to determine the effects of cross-shaped steel eccentricity ratio, concrete strength, steel ratio, and stirrup spacing on the resulting failure mode, load-strain curves, and load-displacement curves. The results indicated that increasing the cross-shaped steel eccentricity ratio reduced the axial capacity and ductility, increasing the concrete strength markedly enhanced the axial capacity but reduced the ductility, and increasing the steel ratio and reducing the stirrup spacing increased the axial capacity and ductility. Two calculation methods for determining the axial capacity of an SRCC-MCS under axial compression were proposed considering the effective lateral confinement pressures provided by the stirrups and monosymmetric cross-shaped steel. The proposed equations were compared with those in three extant codes and found to exhibit improved accuracy and consistency.