In this paper, fatigue crack growth analysis and reliability evaluation of a reinforced cylindrical shell subjected to random loading have been studied. At first, random loading is extracted from an experimentally obtained power spectral density curve. Then, stress analysis of the shell is carried out using Abaqus® (ABAQUS Inc., Palo Alto, CA, USA) standard code with the aid of a shell‐to‐solid submodelling technique, and the critical positions susceptible of crack nucleation are determined. Then, the fatigue crack propagation is simulated three‐dimensionally in these regions using the Zencrack® software (Zentech International Ltd, London, UK), and the fatigue life and reliability are calculated using the central limit theory. For the evaluation of fatigue life of the full‐scale structure, a procedure of fatigue crack growth and linking up of the two adjacent cracks emanating from critical rivet holes is outlined under random cyclic loading. Using stochastic analysis, closed‐form relations are derived for the probability of failure and reliability.