Comparison of subcutaneous and transdermal administration of buprenorphine for pre-emptive analgesia in dogs undergoing elective ovariohysterectomy

Moll, Xavier; Fresno, Laura; García, Félix; Prandi, David; Andaluz, Anna

doi:10.1016/j.tvjl.2009.11.011

Cited by 33 publications

(23 citation statements)

References 20 publications

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“…Owing to interindividual variability and the inability of dogs to verbally communicate pain, it is difficult to recognize and quantify pain in this species. Hence, in some methods of pain assessment, such as the UMPS, researchers have attempted to correlate pain with objective physiological data (Cambridge et al 2000;Moll et al 2011). However, this correlation can be influenced by many factors other than pain (Smith et al 1999).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of nefopam and tramadol on postoperative analgesia in dogs undergoing ovariohysterectomy

Zhang¹,

Li²,

Luan³

et al. 2017

Vet. Med. - Czech

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Relieving perioperative pain can reduce postoperative suffering and improve recovery from anaesthesia in animals. The aim of this study was to compare the analgesic effects of nefopam and tramadol in dogs undergoing ovariohysterectomy. Twenty-four adult mixed-breed female dogs were randomly divided into three groups (n = 8) and received their respective treatments immediately after surgery: Group T (2 mg/kg tramadol, i.v.), Group C (1 mg/kg nefopam, i.v.) and Group D (2 mg/kg nefopam, i.v.). The heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR) and rectal temperature (RT) were measured and the level of analgesia was assessed using the Glasgow Composite Measure Pain Scale (CMPS-SF). The CMPS-SF was performed at least two days before premedication (baseline), every 2 h for the first 8 h (post-extubation), at 12 h and at 24 h. Results showed that the HR in all groups was significantly (P < 0.05) higher at 2 and 6 h than at baseline. The RR in Group T was significantly higher (P < 0.05) at 0 and 2 h than at baseline. Rescue analgesia (0.2 mg/kg morphine, i.v.) was provided if CMPS-SF pain scores greater than or equal to six. Four dogs required rescue analgesia: one dog in Group T at 2 h and three dogs in Group C at 2 and 6 h. No dogs in Group D required rescue analgesia. The CMPS-SF pain scores of dogs in Group C were significantly higher (P < 0.05) than those in Group T at 6, 8 and 12 h. The scores in Group D were significantly lower (P < 0.05) than those in Group C at 2, 4, 6, 8 and 12 h. The scores in Group D were significantly lower (P < 0.05) than those in Group T at 2 and 4 h. However, the scores in Group D were not significantly different compared with Group T. In conclusion, this study suggests that nefopam at 2 mg/kg i.v. produces better postoperative analgesia compared with tramadol at 2 mg/kg i.v. or nefopam at 1 mg/kg i.v. in dogs undergoing ovariohysterectomy.

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Section: Discussionmentioning

confidence: 99%

Comparison of the effects of nefopam and tramadol on postoperative analgesia in dogs undergoing ovariohysterectomy

Zhang¹,

Li²,

Luan³

et al. 2017

Vet. Med. - Czech

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“…However, following completion of this transdermal fentanyl study, a small placebo‐controlled clinical trial of subcutaneously (SQ) administered buprenorphine (20 μg/kg every 6 h) for postoperative pain associated with ovariohysterectomy was reported that used a similar behaviorally based pain scale (23‐point University of Melbourne Pain Scale [UMPS] compared to the 20‐point GCPS) (Moll et al. , 2009).…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of a long‐acting transdermal fentanyl solution compared to buprenorphine for the control of postoperative pain in dogs in a randomized, multicentered clinical study

Linton¹,

Wilson

Newbound³

et al. 2012

Vet Pharm & Therapeutics

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The effectiveness of a long-acting transdermal fentanyl solution compared to buprenorphine for the control of postoperative pain in dogs in a randomized, multicentered clinical study. J. vet. Pharmacol. Therap. 35 (Suppl. 2), 53-64.A prospective, double-blinded, positive-controlled, multicenter, noninferiority clinical study was conducted to evaluate the safety and effectiveness of a longacting transdermal fentanyl solution (TFS) for the control of postoperative pain. Four hundred forty-five client-owned dogs of various breeds were randomly assigned to receive a single dose of TFS (2.6 mg ⁄ kg [50 lL ⁄ kg]) (N = 223) applied 2-4 h prior to surgery or buprenorphine (20 lg ⁄ kg) (N = 222) administered intramuscularly 2-4 h prior to surgery and every 6 h through 90 h. There were 159 (35.7%) males and 286 (64.3%) females ranging from 0.5 to 16 years of age and 3 to 98.5 kg enrolled. Pain was scored using the modified Glasgow Composite Pain Scale with an a priori dropout criteria of ‡8 (20 maximum score). The one-sided upper 95% confidence interval of the mean difference between fentanyl and buprenorphine treatment failures was 5.6%, which was not greater than the a priori selected margin difference of 15%. Adverse events attributed to either treatment were minimal in impact and were approximately equal between groups. Sustained plasma fentanyl concentrations provided by a single pre-emptive dose of TFS are safe and effective and are noninferior to repeated injections of buprenorphine in controlling postoperative pain over 4 days. This long-acting fentanyl formulation provides veterinarians with a novel, registered option for the control of postoperative pain in dogs that improves dosing compliance and potentially mitigates the disadvantages of oral, parenteral, and patch delivered opioids.

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“…The pharmacokinetics and pharmacodynamics of different routes of buprenorphine administration, including intravenous (i.v.) (Morgaz et al., ), subcutaneous (s.c.) (Moll, Fresno, Garcia, Prandi, & Andaluz, ), intramuscular (i.m.) (Linton, Wilson, Newbound, Freise, & Clark, ), transdermal (Moll et al., ), and oral transmucosal (Ko et al., ), have been previously studied in dogs, with the i.v.…”

Section: Introductionmentioning

confidence: 99%

The pharmacokinetics and analgesic effects of extended‐release buprenorphine administered subcutaneously in healthy dogs

Barletta

Ostenkamp

Taylor

et al. 2018

Vet Pharm & Therapeutics

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Buprenorphine is a partial μ agonist opioid used for analgesia in dogs. An extended-release formulation (ER-buprenorphine) has been shown to provide effective analgesia for 72 hr in rats and mice. Six healthy mongrel dogs were enrolled in a randomized, blinded crossover design to describe and compare the pharmacokinetics and pharmacodynamics of ER-buprenorphine administered subcutaneous at 0.2 mg/kg (ER-B) and commercially available buprenorphine for injection intravenously at 0.02 mg/kg (IV-B). After drug administration, serial blood samples were collected to measure plasma buprenorphine concentrations using liquid chromatography/mass spectrometry detection. Heart rate, respiratory rate, body temperature, sedation score, and thermal threshold latency were recorded throughout the study. Median (range) terminal half-life, time to maximum concentration, and maximum plasma concentration of ER-buprenorphine were 12.74 hr (10.43-18.84 hr), 8 hr (4-36 hr), and 5.00 ng/ml (4.29-10.98 ng/ml), respectively. Mild bradycardia, hypothermia, and inappetence were noted in both groups. Thermal threshold latency was significantly prolonged compared to baseline up to 12 hr and up to 72 hr in IV-B and ER-B, respectively. These results showed that ER-buprenorphine administered at a dose of 0.2 mg/kg resulted in prolonged and sustained plasma concentrations and antinociceptive effects up to 72 hr after drug administration.

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Comparison of subcutaneous and transdermal administration of buprenorphine for pre-emptive analgesia in dogs undergoing elective ovariohysterectomy

Cited by 33 publications

References 20 publications

Comparison of the effects of nefopam and tramadol on postoperative analgesia in dogs undergoing ovariohysterectomy

Comparison of the effects of nefopam and tramadol on postoperative analgesia in dogs undergoing ovariohysterectomy

The effectiveness of a long‐acting transdermal fentanyl solution compared to buprenorphine for the control of postoperative pain in dogs in a randomized, multicentered clinical study

The pharmacokinetics and analgesic effects of extended‐release buprenorphine administered subcutaneously in healthy dogs

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