Comparison of Substrates for Measuring Serum Choline Esterase Activity in Hepato-Biliary Disease

Abstract

The efficacy of various Substrates for measuring serum choline esterase for the evaluation of hepatic function was studied using 0-toluoyl-and succinyl-choline, and acetyl, butyryl-and propionylthiocholine. In hepatic disease, the serum choline esterase activity with these Substrates was decreased at a similar rate, showing no significant difference. In 78 -84% of cases with hepatic cirrhosis the enzyme activity with these Substrates was less than 50% of the average level of normal individuals, but in acute and chronic hepatitis only 4-9 and 12-14% of patients showed these lower values, respectively. The present study indicates the usefulness of sequential monitoring of serum choline esterase activity with any of these Substrates for assessing hepatic disease, particularly cirrhosis, and for monitoring the course of hepatic disease.

Association between Distigmine-induced Adverse Events and Serum Butyrylcholinesterase Level: A Multicenter Retrospective Study

“…Additionally, patients with comorbid liver disease (Child-Pugh B or C) were excluded because liver disease reduces serum BChE levels. 7) These factors were considered to possibly aŠect serum BChE levels. Because distigmine is eliminated mainly by the kidneys, the patients' kidney function was also assessed.…”