Comparison of Superb Microvascular Imaging With Color Flow and Power Doppler Imaging of Small Hepatocellular Carcinomas

Dubinsky, Theodore J.; Revels, Jonathan; Wang, Sherry; Toia, Giuseppe V.; Sonneborn, Rachelle; Hippe, Daniel S.; Erpelding, Todd N.

doi:10.1002/jum.14654

Cited by 44 publications

(49 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study results were in good agreement with the results of a previous study using SMI for differentiating small HCCs from benign liver lesions by showing that more central and peripheral vessels were found around liver lesions on SMI than on CDI and PDI (21). Although CDI and PDI are widely used for vascular flow evaluation, they have several clear limitations, including aliasing effects and overwhelming of flow signals, which result in low sensitivity of flow in small or slow vessels (27).…”

Section: Discussionsupporting

confidence: 92%

“…Until now, several studies have demonstrated the diagnostic value of the SMI technique in characterizing focal lesions in the thyroid and breast by revealing low-velocity flow in small vessels within the tumor (181920). However, only a limited number of studies have explored these techniques to reveal tumor vessels in the liver, and these studies had limitations such as small patient numbers or the lack of data comparing the diagnostic performance with that of CDI or PDI (2122). Since residual HCCs after locoregional treatments would increase intratumoral vascularity, we hypothesized that MVFI could sensitively depict intratumoral vascularity in residual or recurrent HCCs after TACE.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Microvascular Flow Imaging of Residual or Recurrent Hepatocellular Carcinoma after Transarterial Chemoembolization: Comparison with Color/Power Doppler Imaging

et al. 2019

View full text Add to dashboard Cite

Objective To determine the feasibility of microvascular flow imaging (MVFI) in comparison with color/power Doppler imaging (CDI/PDI) for detection of intratumoral vascularity in suspected post-transarterial chemoembolization (TACE) residual or recurrent hepatocellular carcinomas (HCCs) by using contrast-enhanced ultrasonography (CEUS) or hepatic angiography (HA) findings as the reference standard. Materials and Methods One hundred HCCs (mean size, 2.2 cm) in 100 patients treated with TACE were included in this prospective study. CDI, PDI, and MVFI were performed in tandem for evaluating intratumoral vascularity of the lesions by using an RS85 ultrasound scanner (Samsung Medison Co., Ltd.). Intratumoral vascularity in each technique was assessed by two radiologists in consensus by using a 5-point scale. Then, one of the two radiologists and another radiologist performed additional image review in the reverse order (MVFI-PDI-CDI) for evaluation of intra- and interobserver agreements. Results were then compared with those of either HA or CEUS as the reference. The McNemar test, logistic regression analysis, and intraclass correlation coefficient (ICC) were used. Results CEUS or HA revealed intratumoral vascularity in 87% (87/100) of the tumors. Sensitivity (79.3%, 69/87) and accuracy (80.0%, 80/100) of MVFI were significantly higher than those of CDI (sensitivity, 27.6% [24/87]; accuracy, 37.0% [37/100]) or PDI (sensitivity, 36.8% [32/87]; accuracy, 44.0% [44/100]) (all p < 0.05). CDI, PDI, and MVFI presented excellent intraobserver (ICCs > 0.9) and good interobserver agreements (ICCs > 0.6). Conclusion MVFI demonstrated significantly higher sensitivity and accuracy than did CDI and PDI for the detection of intratumoral vascularity in suspected residual or recurrent HCCs after TACE.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Microvascular Flow Imaging of Residual or Recurrent Hepatocellular Carcinoma after Transarterial Chemoembolization: Comparison with Color/Power Doppler Imaging

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Therefore, SMI is capable of detecting low-velocity and high-velocity flow, while CDFI is unable to detect very low-flow states due to the different blood flow extraction principles (8). Previous trials have confirmed the higher sensitivity of SMI in depicting central and peripheral vessels in hepatic lesions, compared with CDFI (9,10).…”

Section: Introductionmentioning

confidence: 79%

A comparative study on superb microvascular imaging and conventional ultrasonography in differentiating BI‑RADS 4 breast lesions

Zhu

Zhang

et al. 2019

Oncol Lett

View full text Add to dashboard Cite

This prospective study aimed to explore the diagnostic value of superb microvascular imaging (SMI) in differentiating Breast Imaging Reporting and Data System (BI-RADS) 4 breast lesions compared with conventional ultrasonography (US). A total of 111 patients with 116 breast lesions underwent grayscale ultrasound (US), colour Doppler flow imaging (CDFI) and SMI breast imaging between February 2016 and May 2018. CDFI and SMI were performed to evaluate vascular quantity, morphology, and distribution characteristics. The detection of malignancy was compared between grayscale US alone, US + CDFI and US + SMI in terms of the BI-RADS stratification system. SMI was observed to be significantly more accurate in distinguishing malignant breast lesions (86.67%) compared with CDFI (80.00%) (P<0.001). Among malignant lesions, SMI detected 80.00% of those that contained ≥4 vessels, while CDFI only detected 56.67%. Penetrating and branching vessels were identified by SMI in 53.33% of malignant breast lesions and by CDFI in 10.00%. There was no significant difference in vascular distribution by SMI (P=0.094) and by CDFI (P=0.087). US + SMI was associated with higher sensitivity, specificity, and accuracy rates (86.67, 83.72 and 84.48%, respectively) compared with US + CDFI (80.00, 72.09 and 74.14%, respectively). The area under the curve values from receiver operating characteristic analysis of US + SMI, US + CDFI and US alone were 0.852 [95% confidence interval (CI): 0.768–0.936)] 0.760 (95% CI: 0.660–0.860), 0.698 (95% CI: 0.589–0.807), respectively (P<0.001). SMI yielded more detailed vascular information associated with malignant breast masses when compared with conventional US. Therefore, as an adjunct to grayscale, SMI exhibited a markedly improved diagnostic capability in distinguishing malignant and benign breast lesions, particularly those of BI-RADS category 4.

show abstract

“…For hepatocellular carcinoma and other kinds of malignant hepatic tumors, no specific vascular patterns were found on SMI . Without characterizing the morphologic patterns of vessels, Dubinsky et al examined the number of vessels in the hepatic lesions. They found that although more vessels were detected in hepatocellular carcinoma lesions than in benign lesions, the overall diagnostic performance was not high.…”

Section: Superb Microvascular Imaging For Characterization Of Liver Dmentioning

confidence: 99%

Clinical Applications of Superb Microvascular Imaging in the Liver, Breast, Thyroid, Skeletal Muscle, and Carotid Plaques

Jiang

Huang

Shen

et al. 2019

J of Ultrasound Medicine

103

View full text Add to dashboard Cite

This article reviews the clinical applications of Superb Microvascular Imaging (SMI; Canon Medical Systems, Otawara, Japan) in the liver, breast, thyroid, skeletal muscle, and carotid plaques. Diseases that are closely associated with angiogenesis can be diagnosed by SMI in a relatively early phase, and using SMI can prevent adverse reactions associated with the contrast agents used in contrast‐enhanced ultrasound. Super Microvascular Imaging also shows particular value in grading disease activities and monitoring therapeutic responses. Although SMI has some limitations, such as a lack of clinical standards, it can add information to conventional ultrasound examinations and may become a noninvasive alternative to invasive diagnostic procedures for many clinical conditions.

show abstract

Comparison of Superb Microvascular Imaging With Color Flow and Power Doppler Imaging of Small Hepatocellular Carcinomas

Cited by 44 publications

References 8 publications

Microvascular Flow Imaging of Residual or Recurrent Hepatocellular Carcinoma after Transarterial Chemoembolization: Comparison with Color/Power Doppler Imaging

Microvascular Flow Imaging of Residual or Recurrent Hepatocellular Carcinoma after Transarterial Chemoembolization: Comparison with Color/Power Doppler Imaging

A comparative study on superb microvascular imaging and conventional ultrasonography in differentiating BI‑RADS 4 breast lesions

Clinical Applications of Superb Microvascular Imaging in the Liver, Breast, Thyroid, Skeletal Muscle, and Carotid Plaques

Contact Info

Product

Resources

About