Comparison of surface contamination with cyclophosphamide and fluorouracil using a closed-system drug transfer device versus standard preparation techniques

Harrison, Bruce R.; Peters, Byron G.; Bing, Michael R.

doi:10.2146/ajhp050258

Cited by 93 publications

(77 citation statements)

References 35 publications

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“…Previous studies have documented the impact of PhaSeal Õ on workplace contamination by doing surface and personnel sampling for the presence of antineoplastic agents such as cyclophosphamide, 5-fluorouracil, and ifosfamide. 12,13 Harrison et al, 12 for instance, showed a 93% reduction in the number of positive samples when preparing 5-fluorouracil, whereas Wick et al 13 report a major reduction with cyclophosphamide (67%). Overall, our findings confirm these earlier results and demonstrate a reduction of environmental contamination when using the PhaSeal Õ system.…”

Section: Favier Et Al 41mentioning

confidence: 99%

The PhaSeal® system: Impact of its use on workplace contamination and duration of chemotherapy preparation

Favier

Labrosse

Gilles-Afchain

et al. 2011

J Oncol Pharm Pract

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Section: Favier Et Al 41mentioning

confidence: 99%

The PhaSeal® system: Impact of its use on workplace contamination and duration of chemotherapy preparation

Favier

Labrosse

Gilles-Afchain

et al. 2011

J Oncol Pharm Pract

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“…Many studies have reported that the PhaSeal R system, a closed medical device to prepare drugs, is useful in decreasing the degree of exposure, [21][22][23][24][25] and this system was introduced to our hospital in April 2008 following careful discussion. However, this medical device is expensive and cannot be introduced to all medical institutions in Japan, given the National Health Insurance (NHI) system.…”

Section: Discussionmentioning

confidence: 99%

An Environmental and Biological Study of Occupational Exposure to Cyclophosphamide in the Pharmacy of a Japanese Community Hospital Designated for the Treatment of Cancer

Tanimura

Yamada

Sugiura

et al. 2009

JOURNAL OF HEALTH SCIENCE

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Cancer treatment in Japan is considered to be very progressive in the use of antineoplastic agents. Pharmacists are required to compound more antineoplastic preparations recently and thus are at risk for exposure to antineoplastic agents. In Japan, healthcare professionals have recognized the need for protection, but there have been few reports of environmental contamination or occupational exposure to antineoplastic agents. In the present study, urine samples over 24 hr from compounding pharmacists and wipe samples from the compounding room were collected to analyze levels of cyclophosphamide (CP). CP was detected in urine samples from all 4 pharmacists (mean = 165.3 ng/24 hr) and for all wipe samples of the compounding room. From the results of these tests, the standard operating procedure (SOP) of the pharmacy was revised as a protective measure. The tests were then repeated and CP was detected again in the urine of all 4 compounding pharmacists, though the mean CP level was reduced from 165.3 to 47.4 ng/24 hr after the revision of the SOP. Although there was no correlation between the amount of CP compounded and the CP levels in urine initially, the 2 values were significantly correlated after the revision of the SOP (R 2 = 0.87).

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“…Negative reproductive health outcomes are also associated with antineoplastic exposure (93,97,98). Spontaneous abortions have been reported approximately twice more often among exposed pregnancies than unexposed ones (94); the same goes for congenital malformations, infertility, and possibly leukaemia, as well as other cancers (80,94,99).…”

Section: Occupational Exposure To Antineoplastic Drugsmentioning

confidence: 99%

Forgotten public health impacts of cancer – an overview

Viegas

Ladeira

Veiga

et al. 2017

Archives of Industrial Hygiene and Toxicology

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Cancer is one of the diseases of greatest concern in developed countries and much effort has been invested in discovering and developing therapeutics for curing cancer. Despite the improvements in antineoplastic therapeutics in the last decades, cancer is still one of the most harmful diseases worldwide. The global burden of cancer also implies financial costs: these can be direct costs, such as those related to treatment, care, and rehabilitation and indirect, which include the loss of economic output due to missed work (morbidity costs) and premature death (mortality costs). There are also hidden costs such as health insurance premiums and nonmedical expenses that are worth noting. This paper intends to present an overview of the generally forgotten impacts that the increasing number of cancer cases can have on the environment, workers who handle antineoplastic drugs, and health services. The knowledge available of each of the impacts will be addressed and discussed regarding the expected development. Overall, lessons learnt reflect on the impact of cancer through aspects not commonly evidenced in the literature or even considered in socio-economic analysis, in part due to the fact that these are difficult to contemplate in direct and indirect cancer costs already defined. Attention may be drawn to the need of continuous investment in prevention to reduce the negative impact on the environment, and in the health of workers who handle antineoplastic drugs for patients' treatment. KEY WORDS: costs of cancer; global burden; occupational healthGlobally, cancer is a growing public health problem. It is the second cause of death (21 %) after cardiovascular diseases (48 %), followed by respiratory diseases (12 %) in the sector of non-communicable diseases or diseases caused by non-infectious and non-transmissible medical conditions (1). Important resources are mobilised in order to improve research on new therapeutics, and ultimately devise a cure for this particular disease. Despite the increase in the effectiveness and specificity of chemotherapeutic treatments, cancer still remains one of the most harmful diseases (2-4).In 2012, worldwide incidence of cancer rose to an estimated 14 million new cases per year, with an estimated 8.2 million cancer deaths. The most common cancers diagnosed were of lung (1.8 million cases, 13 %), breast (1.7 million, 11.9 %) and colon (1.4 million, 9.7 %) (1

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Comparison of surface contamination with cyclophosphamide and fluorouracil using a closed-system drug transfer device versus standard preparation techniques

Cited by 93 publications

References 35 publications

The PhaSeal® system: Impact of its use on workplace contamination and duration of chemotherapy preparation

The PhaSeal® system: Impact of its use on workplace contamination and duration of chemotherapy preparation

An Environmental and Biological Study of Occupational Exposure to Cyclophosphamide in the Pharmacy of a Japanese Community Hospital Designated for the Treatment of Cancer

Forgotten public health impacts of cancer – an overview

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