Comparison of Surgical Outcomes for Hepatocellular Carcinoma in Patients With Hepatitis B Versus Hepatitis C: A Western Experience

Roayaie, Sasan; Ben-Haim, Menahem; Emre, Sükrü; Fishbein, Thomas M.; Sheiner, Patricia A.; Miller, Charles M.; Schwartz, Myron

doi:10.1007/s10434-000-0764-8

Cited by 100 publications

(66 citation statements)

References 39 publications

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“…Many other studies have shown that macrovascular invasion is a primary factor that influences prognosis after OLT in HCC patients [12,13,[15][16][17][18] . Shetty et al [18] have concluded that macrovascular invasion and AFP levels were prognostic factors that influenced CSR and TFS.…”

Section: Discussionmentioning

confidence: 99%

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Indicators of prognosis after liver transplantation in Chinese hepatocellular carcinoma patients

Yan²,

Yang³

et al. 2009

WJG

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AIM:To identify prognostic factors of patients with hepatocellular carcinoma (HCC), who were treated by orthotopic liver transplantation (OLT). METHODS:From January 2000 to October 2006, 165 patients with HCC underwent OLT. Various clinicopathological risk factors for actuarial and recurrencefree survival were identified using the Kaplan-Meier method with the log-rank test. The Cox proportional hazards model was used to identify independently predictive factors for actuarial and recurrence-free survival, which were used to propose new selection criteria. We compared the outcome of the subgroup patients meeting different criteria. Survival analysis was performed using the Kaplan-Meier method with the log-rank test. RESULTS:The median follow-up was 13.0 mo (2.8-69.5 mo). Overall, 1-, 2-, 3-and 5-year actuarial survival was 73.3%, 45.6%, 35.4% and 32.1%, respectively. One-, 2-, 3-and 5-year overall recurrencefree survival was 67.0%, 44.3%, 34.5% and 34.5%, respectively. In univariate analysis, number of tumors, total tumor size, lobar distribution, differentiation, macrovascular invasion, microvascular invasion, capsulation of the tumor, and lymph node metastasis were found to be associated significantly with actuarial and tumor-free survival. By means of using the multivariate Cox proportional hazards model, total tumor size and macrovascular invasion were found to be independent predictors of actuarial and tumor-free survival. When the selection criteria were expanded into the proposed criteria, there was no significant difference in 1-, 2-, 3-and 5-year actuarial and tumor-free survival of the 49 patients who met the proposed criteria (97.6%, 82.8%, 82.8% and 82.8%, and 90.7%, 82.8%, 68.8% and 68.8%, respectively) compared with that of patients who met the Milan or University of California, San Francisco (UCSF) criteria. CONCLUSION:Macrovascular invasion and total tumor diameter are the strongest prognostic factors. The proposed criteria do not adversely affect the outcome of liver transplantation for HCC, compared with the Milan or UCSF criteria.

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Section: Discussionmentioning

confidence: 99%

“…Numerous studies have shown that tumor size is an important prognostic factor for liver transplantation in patients with HCC [8,12,13] . Bismuth et al [12] have found that HCC patients with two or fewer tumors, each with a diameter ≤ 3 cm, had an 83% 3-year CSR and TFS following liver transplantation and hepatectomy.…”

Section: Discussionmentioning

confidence: 99%

Indicators of prognosis after liver transplantation in Chinese hepatocellular carcinoma patients

Yan²,

Yang³

et al. 2009

WJG

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“…In Taiwan, HCC is a leading neoplasm due to the high prevalence of chronic viral hepatitis [3][4][5] . Surgical resection, liver transplantation and local ablation therapy are considered potentially curative therapies for HCC nowadays [6,7] . However, only 9% to 27% of patients are suitable for operation [8,9] .…”

Section: Introductionmentioning

confidence: 99%

Factors for early tumor recurrence of single small hepatocellular carcinoma after percutaneous radiofrequency ablation therapy

Cheng²,

Lai³

et al. 2005

WJG

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AIM:To evaluate the factors affecting the early tumor recurrence within one year in cirrhotic patients having a single small hepatocellular carcinoma (HCC) after complete tumor necrosis by radiofrequency ablation (RFA) therapy. METHODS:Thirty patients with a single small HCC received RFA therapy by a RFA 2000 generator with LeVeen needle. Tri-phase computerized tomogram was followed every 2 to 3 mo after RFA. The clinical effects and tumor recurrence were recorded. RESULTS:The initial complete tumor necrosis rate was 86.7%. Twenty-two patients were followed for more than one year. The local and overall recurrence rates were 13.6% and 36.4%, 33.3% and 56.2%, 46.6% and 56.2% at 12, 24 and 30 mo, respectively. No major complication or procedure-related mortality was found. The risk factors for early local tumor recurrence within one year were larger tumor size, poor pathologic differentiation of tumor cells and advanced tumor staging. The age of patients with new tumor formation within one year was relatively younger (55.1±8.3 vs 66.7±10.8, P = 0.029). CONCLUSION:Large tumor size, poor pathologic differentiation of tumor cells and advanced tumor staging are the risk factors for early local tumor recurrence within one year, and young age is the positive predictor for new tumor formation within one year.

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“…Hence, the recurrence of HCC is more common among the HCV recipients and thus reduced survival [92]. The immunosuppressive treatment after liver transplantation is associated with increased risk of tumor recurrence.…”

Section: Patient Related Factorsmentioning

confidence: 99%

Surgical Management of Primary Hepatocellular Carcinoma

Chan¹,

Thorat²

2013

Hepatic Surgery

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Comparison of Surgical Outcomes for Hepatocellular Carcinoma in Patients With Hepatitis B Versus Hepatitis C: A Western Experience

Cited by 100 publications

References 39 publications

Indicators of prognosis after liver transplantation in Chinese hepatocellular carcinoma patients

Indicators of prognosis after liver transplantation in Chinese hepatocellular carcinoma patients

Factors for early tumor recurrence of single small hepatocellular carcinoma after percutaneous radiofrequency ablation therapy

Surgical Management of Primary Hepatocellular Carcinoma

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