Comparison of Surgically Excised Premacular Membranes in Eyes with Macular Pucker and Proliferative Vitreoretinopathy

Guenther, Stefanie R; Schumann, Ricarda G.; Hagenau, Felix; Wolf, Armin; Priglinger, Siegfried; Vogt, Denise

doi:10.1080/02713683.2018.1542006

Cited by 26 publications

(25 citation statements)

References 30 publications

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“…The main component of the ECM is extracellular collagen fibrils with fragments of ILM 44 . Early studies divided the collagen types into native vitreous collagen (NVC), left on the retinal surface following vitreoschis or partial PVD, and newly formed collagen (NFC), presumably secreted by the cellular layer 41,45 . The two collagens differ in that NVC has smaller fibrils (<16 nm diameter) with a more regular fibrillar arrangement than NFC 41,45,46 …”

Section: Histopathology and Pathogenesismentioning

confidence: 99%

Epiretinal membrane: A review

Fung

Galvin

Tran

2021

Clinical Exper Ophthalmology

116

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The prevalence of epiretinal membrane (ERM) is 7% to 11.8%, with increasing age being the most important risk factor. Although most ERM is idiopathic, common secondary causes include cataract surgery, retinal vascular disease, uveitis and retinal tears. The myofibroblastic pre‐retinal cells are thought to transdifferentiate from glial and retinal pigment epithelial cells that reach the retinal surface via defects in the internal limiting membrane (ILM) or from the vitreous cavity. Grading schemes have evolved from clinical signs to ocular coherence tomography (OCT) based classification with associated features such as the cotton ball sign. Features predictive of better prognosis include absence of ectopic inner foveal layers, cystoid macular oedema, acquired vitelliform lesions and ellipsoid and cone outer segment termination defects. OCT‐angiography shows reduced size of the foveal avascular zone. Vitrectomy with membrane peeling remains the mainstay of treatment for symptomatic ERMs. Additional ILM peeling reduces recurrence but is associated with anatomical changes including inner retinal dimpling.

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Section: Histopathology and Pathogenesismentioning

confidence: 99%

Epiretinal membrane: A review

Fung

Galvin

Tran

2021

Clinical Exper Ophthalmology

116

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“…Während bei der idiopathischen epiretinalen Gliose das Ausschwemmen von retinalen Pigmentepithelzellen (RPE) oder die Ansammlung von Entzündungszellen keine zentrale Rolle bei der Entstehung der epiretinalen Membranen spielt, sind diese Zellen entscheidende Faktoren für die Pathogenese der sekundären epiretinalen Gliose [41]. Sie lagern sich aus dem Glaskörperraum kommend oder von subretinal und retinal migrierend auf der Netzhautoberfläche ab und bilden dichte Zellverbände.…”

Section: Pathogeneseunclassified

Stellungnahme von BVA, DOG und RG zur Entwicklung, Diagnostik und Behandlung der epiretinalen Gliose

2021

Klin Monbl Augenheilkd

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“…For a very long time, postoperative premacular membranes were considered to be macular pucker, known also as epiretinal membrane (ERM). Alternatively, recent reports showed membranes with extreme presentation are proliferative vitreoretinopathy (PVR) [2,3]. Specific risk factors for PVR have been identified including uveitis, large, giant, or multiple tears, vitreous hemorrhage, preoperative or postoperative choroidal detachments, aphakia, multiple previous surgeries, and large detachments involving >2 quadrants of the eye [4].…”

Section: Introductionmentioning

confidence: 99%

“…The molecular composition of the premacular membranes was discovered several decades ago [5][6][7][8]. Interestingly, both ERM and PVR membranes express integrins, α-SMA, galectin, EMMPRIN, RCS, IBA1, and collagen-type I. Idiopathic membranes are composed of myofibroblasts, glial cells, and fibroblasts, while PVR membranes are composed predominantly of retinal pigment epithelial (RPE) cells, glial cells, and myofibroblasts [3,7,9].…”

Section: Introductionmentioning

confidence: 99%

Postoperative Macular Proliferative Vitreoretinopathy: A Case Series and Literature Review

Khateb¹,

Aweidah²,

Halpert³

et al. 2021

Case Rep Ophthalmol

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Premacular membranes developing following pars plana vitrectomy (PPV) can cause significant anatomical and functional deficits to the macula. Recent reports showed that postoperative premacular membranes are a localized presentation of macular proliferative vitreoretinopathy (mPVR). Here, we report retrospectively a case series of 5 patients with severe mPVR which developed following uneventful PPV and were followed up to 32 months in the Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, between October 2016 and February 2020. All patients underwent primary repair of rhegmatogenous retinal detachment (RRD) before mPVR developed. Mean best-corrected visual acuity (BCVA) at presentation was 20/76 Snellen (0.58 LogMAR). Median duration of the retinal detachment time until surgery was 1.5 days (range 1–21 days). Mean interval time from last normal follow-up exam to diagnosis of mPVR was 19 days (range 10–28). BCVA dropped from a mean of 20/38 Snellen (0.28 LogMAR) prior to mPVR development to 20/166 Snellen (0.92 LogMAR) following its development, recovering to 20/57 Snellen (0.45 LogMAR) after peeling of membranes. Mean central macular thickness measured by optical coherence tomography decreased from 711 to 354 μm postsurgery. In conclusion, short-term mPVR is a different entity from macular pucker in terms of rapid development, structural distortion, and visual compromise. Surgical treatment significantly restores macular function and anatomy.

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Comparison of Surgically Excised Premacular Membranes in Eyes with Macular Pucker and Proliferative Vitreoretinopathy

Cited by 26 publications

References 30 publications

Epiretinal membrane: A review

Epiretinal membrane: A review

Stellungnahme von BVA, DOG und RG zur Entwicklung, Diagnostik und Behandlung der epiretinalen Gliose

Postoperative Macular Proliferative Vitreoretinopathy: A Case Series and Literature Review

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