Comparison of survival and regional failure between accelerated partial breast irradiation and whole breast irradiation

Shah, Chirag; Wilkinson, James A.; Lyden, Maureen; Mbah, Alfred K.; Keisch, Martin; Beitsch, Peter D.; Vicini, Frank A.

doi:10.1016/j.brachy.2012.01.008

Cited by 24 publications

(6 citation statements)

References 16 publications

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“…In the meta‐analysis, patients who received APBI had equivalent SF (OR = 1.06; 95% CI = 0.55–2.04; p = 0.853) compared with patients who received WBI, there was no statistically significant difference between group APBI and group WBI (Table ). Six eligible studies reported the data regarding DM. In the meta‐analysis, patients who received APBI had equivalent DM (OR = 0.70; 95% CI = 0.45–1.08; p = 0.104) compared with patients who received WBI, there was no statistically significant difference between group APBI and group WBI (Table ). Eight eligible studies reported the data regarding OS. In the meta‐analysis, patients who received APBI had equivalent OS (OR = 0.88; 95% CI AA = 0.73–1.06; p = 0.177) compared with patients who received WBI, there was no statistically significant difference between group APBI and group WBI (Table ). Six eligible studies reported the data regarding DFS.…”

Section: Resultsmentioning

confidence: 98%

“…2,606 articles were identified by MEDLINE search, 1250 by EMBASE, and 117 by Cochrane Library. Among them, 11 articles fulfilled the inclusion criteria . The search was illustrated in a flow diagram in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…In as much as different articles and authors reported on patients in the same study at different times , only the most recent article was included to prevent duplication . If the same author reported different patient population, both articles were included . This meta‐analysis included 11 studies with a total of 7,097 patients.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy and Safety of Accelerated Partial Breast Irradiation after Breast-conserving Surgery: A Meta-analysis of Published Comparative Studies

et al. 2013

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To compare the treatment outcomes between accelerated partial breast irradiation (APBI) and conventional whole-breast irradiation (WBI) and to explore the efficacy and safety of APBI as an adjuvant treatment for early-stage breast cancer who received breast-conserving therapy. Eligible studies were identified on Medline, Embase, and the Cochrane Library updated to July 10, 2012. Comparative studies were considered for inclusion. Analyses were carried out using Stata software. Eleven comparative studies with a total of 7,097 patients were included. The meta-analysis showed that there were no statistically significant differences between group APBI and group WBI associated with the supraclavicular failure, distant metastasis, overall survival, and disease-free survival, while local recurrence (LR) and axillary failure (AF) increased in group APBI. The sensitivity analysis indicated that both the LR and AF were not statistically significant difference between the two groups. In the subgroup analysis, LR was statistically significantly higher in group APBI for patients with the age <60, large tumor size, and unknown margin status. APBI is a safe treatment modality and could become a potential option for the delivery of adjuvant radiation therapy in patients receiving breast-conserving therapy, especially for the suitable group that was classified by the American Society of Radiation Oncology Consensus Panel.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

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Efficacy and Safety of Accelerated Partial Breast Irradiation after Breast-conserving Surgery: A Meta-analysis of Published Comparative Studies

et al. 2013

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“…Real-time, imageguided brachytherapy (IGBT) now provides excellent conformal RT and is a clear alternative to EBRT in many tumor localizations. Indeed, the use of BT for prostate cancer (both HDR and seeds) and, more recently, for accelerated partial breast irradiation (APBI), is strong and growing stronger [10,11].…”

Section: Promisesmentioning

confidence: 99%

Promises and pitfalls of new technology in radiotherapy

Guedea

2012

Clin Transl Oncol

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“…Sie ist jedoch jetzt schon eine Option bei Patientinnen, bei denen eine Homogenbestrahlung der gesamten Brust aus unterschiedlichsten Gründen (z.B. bei radiogener Vorbelastung oder bei entsprechender Komorbidität) nicht möglich ist (28,29), wobei in jüngster Zeit auch die interstitielle Multikatheter-Brachytherapie an Bedeutung zu gewinnen scheint (30,31).…”

Section: Fazit Für Die Praxisunclassified

Partialbrustbestrahlung nach Mammakarzinom

Köppen¹

2012

Onkologische Welt

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ZusammenfassungRadioonkologischer Standard im Rahmen der Brusterhaltenden Therapie ist nach wie vor die postoperative Ganzbrustbestrahlung mit zusätzlicher Aufsättigung der ehemaligen Tumorregion. Zahlreiche Bestrahlungstechniken wurden mittlerweile entwickelt, um den strahlentherapeutischen Boost der ursprünglichen Tumorlokalisation in den operativen Eingriff zu integrieren oder ihn ihm unmittelbar anzuschließen. Neben dem INTRABEAM System werden weitere Modalitäten zur alleinigen Radiatio des Tumorbetts bzw. in Kombination mit Ganzbrustbestrahlung dargestellt.

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Comparison of survival and regional failure between accelerated partial breast irradiation and whole breast irradiation

Cited by 24 publications

References 16 publications

Efficacy and Safety of Accelerated Partial Breast Irradiation after Breast-conserving Surgery: A Meta-analysis of Published Comparative Studies

Efficacy and Safety of Accelerated Partial Breast Irradiation after Breast-conserving Surgery: A Meta-analysis of Published Comparative Studies

Promises and pitfalls of new technology in radiotherapy

Partialbrustbestrahlung nach Mammakarzinom

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