Comparison of Survival between Anatomic and Non-Anatomic Liver Resection in Patients with Hepatocellular Carcinoma: Significance of Surgical Margin in Non-Anatomic Resection

Nanashima, Atsushi; Sumida, Yorihisa; Abo, Toru; Nagasaki, Toshiya; Tobinaga, Syuuichi; Fukuoka, Hidetoshi; Takeshita, Hiroaki; Hidaka, Shigekazu; Tanaka, Ken; Sawai, Terumitsu; Yasutake, Toru; Nagayasu, T

doi:10.1080/00015458.2008.11680280

Cited by 15 publications

(14 citation statements)

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“…The effects of RM status during HCC resection on long‐term patient outcomes have been widely examined. Most studies have identified insufficient RMs as an unfavourable factor for survival, with 16–50% marginal recurrence rates . Shi et al .…”

Section: Discussionmentioning

confidence: 99%

Survival benefit with IMRT following narrow‐margin hepatectomy in patients with hepatocellular carcinoma close to major vessels

Wang

et al. 2015

Liver International

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Section: Discussionmentioning

confidence: 99%

Survival benefit with IMRT following narrow‐margin hepatectomy in patients with hepatocellular carcinoma close to major vessels

Wang

et al. 2015

Liver International

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“…Twenty-two studies have been published comparing AR versus NAR, all between 1996 and 2010, that matched the selection criteria [7][8][9][10][11][12][13][14][15][19][20][21][22][23][24][25][26][27][28][29][30]. Of these studies, one did not provide indications for AR and NAR [7], one focused on comparative data on the different types of hepatic resection [31], one is a nationwide survey report [19]; all three studies were excluded.…”

Section: Selection Of Trialsmentioning

confidence: 99%

Meta-analysis of anatomic resection versus nonanatomic resection for hepatocellular carcinoma

Zhou

et al. 2011

Langenbecks Arch Surg

107

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“…AR seemed to be recommended prior to NAR for HCC with solitary tumors which diameters were no longer than 5 cm. However, Nanashima et al (2008) reported that in his study the patients were high selection of solitary tumors located within one segment and no macroscopic venous invasion occurred. Although patients in the AR group were characterized by larger tumor size, no differences of early intra-hepatic recurrence, late intra-hepatic recurrence, local recurrence and 5 years disease-free survival were found between AR group and NAR group.…”

Section: 1771 Anatomic Resection Versus Nonanatomic Resection For Hcmentioning

confidence: 99%

Recurrence after Anatomic Resection Versus Nonanatomic Resection for Hepatocellular Carcinoma: A Meta-analysis

Miao²,

Wu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The impact of anatomic resection (AR) as compared to non-anatomic resection (NAR) for hepatocellular carcinoma (HCC) as a factor for preventing intra-hepatic and local recurrence after the initial surgical procedure remains controversial. A systematic review and meta-analysis of nonrandomized trials comparing anatomic resection with non-anatomic resection for HCC published from 1990 to 2010 in PubMed and Medline, Cochrane Library, Embase, and Science Citation Index were therefore performed. Intra-hepatic recurrence, including early and late, and local recurrence were considered as primary outcomes. As secondary outcomes, 5 year survival and 5 year disease-free survival were considered. Pooled effects were calculated utilizing either fixed effects or random effects models. Eleven non-randomized studies including 1,576 patients were identified and analyzed, with 810 patients in the AR group and 766 in the NAR group. Patients in the AR group were characterized by lower prevalence of cirrhosis, more favorable hepatic function, and larger tumor size and higher prevalence of macrovascular invasion compared with patients in the NAR group. Anatomic resection significantly reduced the risks of local recurrence and achieved a better 5 years disease-free survival. Also, anatomic resection was marginally effective for decreasing the early intra-hepatic recurrence. However, it was not advantageous in preventing late intra-hepatic recurrence compared with non-anatomic resection. No differences were found between AR and NAR with respect to postoperative morbidity, mortality, and hospitalization. Anatomic resection can be recommended as superior to non-anatomic resection in terms of reducing the risks of local recurrence, early intra-hepatic recurrence and achieving a better 5 year disease-free survival in HCC patients.

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Comparison of Survival between Anatomic and Non-Anatomic Liver Resection in Patients with Hepatocellular Carcinoma: Significance of Surgical Margin in Non-Anatomic Resection

Cited by 15 publications

References 0 publications

Survival benefit with IMRT following narrow‐margin hepatectomy in patients with hepatocellular carcinoma close to major vessels

Survival benefit with IMRT following narrow‐margin hepatectomy in patients with hepatocellular carcinoma close to major vessels

Meta-analysis of anatomic resection versus nonanatomic resection for hepatocellular carcinoma

Recurrence after Anatomic Resection Versus Nonanatomic Resection for Hepatocellular Carcinoma: A Meta-analysis

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