Comparison of survival outcomes between squamous cell carcinoma and adenocarcinoma/adenosquamous carcinoma of the cervix after radical radiotherapy and chemotherapy

Liu, Ping; Ji, Mei; Kong, Yanxiang; Huo, Zhifeng; Lv, Qiubo; Xie, Qinghuang; Wang, Danbo; Chen, Biliang; Wang, Hailin; Cui, Zhonghui; Wang, Qianqing; Bin, Xiaonong; Lang, Jinghe; Chen, Chunlin

doi:10.1186/s12885-022-09401-x

Cited by 11 publications

(12 citation statements)

References 25 publications

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“…In another study, Liu et al. reported that for the same stages, and irrespective of radiotherapy or chemotherapy, SCC resulted in better treatment effects and prognoses ( 18 ). Analysis also showed that NE accounted for the lowest risk score for the onset of SPM in our nomograms; this was due to poor survival.…”

Section: Discussionmentioning

confidence: 99%

The risk and latency evaluation of secondary primary malignancies of cervical cancer patients who received radiotherapy: A study based on the SEER database

et al. 2023

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ObjectivesTo study the risk factors for the onset of secondary primary malignancies (SPM) and the latency between SPM and cervical cancer after radiotherapy.MethodsWe selected patients with cervical cancer who underwent radiotherapy between 2000 and 2019 from the Surveillance, Epidemiology, and End Results (SEER) database. And the data of patients with cervical cancer who underwent radiotherapy in Guangxi Medical University Cancer Hospital during January 1,1997 to December 31,2016 were collected and analyzed. The factors associated with SPM onset and latency were then estimated by nomograms based on logistic regression and a complete risk model. Dynamic risk plots were performed by Poisson regression.ResultsA total of 32,313 cases of cervical cancer who underwent radiotherapy were downloaded from the SEER database; of these, 19,439 cases had a complete dataset and were included in the final analysis. In total, 561 cases suffered from SPM; the remaining 18,878 did not. And a total of 1486 cases of cervical cancer who underwent radiotherapy from Guangxi Medical University Cancer Hospital were analyzed, 27 cases caught SPM and the rest of 1459 cases did not. Patients with SPM were older than those without SPM(p=0.000); significant associations were also identified between SPM and white race(p=0.000), localized stage (p=0.000), squamous carcinoma (SCC)(p=0.003), surgery(p=0.000), and combination radiotherapy (p=0.026). A logistic regression nomogram showed that older age (HR:1.015, 95%CI:1.009-1.021, p=0.000), localized stage (HR:4.056, 95%CI: 2.625-6.269, p=0.000) and regional stage (HR: 3.181, 95%CI:2.094-4.834, p=0.000), white (HR: 1.722, 95%CI:1.145-2.590, p=0.000) and black race (HR: 1.889, 95%CI:1.327-2.689, p=0.000), and the receipt of surgery (HR: 1.381, 95%CI:1.151-1.657, p=0.000) were all independent risk factors for the onset of SPM. The largest proportion of cases involved SPM in the female reproductive system. A dynamic risk plot showed that age, race, stage, and surgery had impacts on the latency of SPM onset. A competing risk regression analysis nomogram showed that age (HR: 1.564, 95%CI: 1.272-1.920, p=0.000), surgery (HR: 1.415, 95%CI: 1.140-1.760, p=0.002), localized stage (HR: 8.035, 95%CI: 4.502-14.340, p=0.000) and regional stage (HR: 4.904, 95%CI: 2.790-8.620, p=0.000), and black race (HR: 1.786, 95%CI: 1.161-2.750, p=0.008) all had significant impacts on the cumulative incidence and latency of SPM.ConclusionsAdvanced age, the receipt of surgery, earlier stages, and white and black race were identified as risk factors for SPM onset and influenced latency in patients with cervical cancer after radiotherapy.

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Section: Discussionmentioning

confidence: 99%

The risk and latency evaluation of secondary primary malignancies of cervical cancer patients who received radiotherapy: A study based on the SEER database

et al. 2023

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“…CAC is significantly different from squamous lesions because of its higher aggressiveness and poorer prognostic outcome. [29,30] Therefore, separately investigating CAC could be of great significance to identify more significant differences from other cervical diseases and could help provide new insights for improving patient management approach. Apart from histological type, other factors like age, tumor size, FIGO stage, lympho-vascular space invasion, stromal invasion, concurrent chemotherapy and parametrial involvement are also identified in prior research regarding cervical carcinoma, which are integrated in existing prediction models.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a nomogram to predict overall survival for cervical adenocarcinoma: A population-based study

Fa,

Yang,

Niu

et al. 2023

Medicine

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This study aimed to develop and validate a nomogram for predicting the overall survival of cervical adenocarcinoma (CAC) patients using a large database comprising patients with different ethnicities. We enrolled primary CAC cases with complete clinicopathological and survival data from the Surveillance, Epidemiology, and End Results program during 2004 to 2015. For training set samples, this work applied the Cox regression model to obtain factors independently associated with patient prognosis, which could be incorporated in constructing the nomogram. Altogether 3096 qualified cases were enrolled, their survival ranged from 0 to 155 (median, 45.5) months. As revealed by multivariate regression, age, marital status, tumor size, grade, International Federation of Gynecology and Obstetrics (FIGO) classification, pelvic lymph node metastasis, surgery, and chemotherapy served as the factors to independently predict CAC (all P < .05). We later incorporated these factors for constructing the nomogram. According to the concordance index determined, this nomogram had superior discrimination over FIGO classification system (all P < .001). Based on calibration plot, the predicted value was consistent with actual measurement. As revealed by time-independent area under the curves, our constructed nomogram had superior 5-year overall survival over FIGO system. Additionally, according to decision curve analysis, our constructed nomogram showed high clinical usefulness as well as favorable discrimination. Our constructed nomogram attains favorable performances, indicating that it may be applied in predicting survival for CAC patients.

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“…20,21 Several studies, including ours, have found that cervical adenocarcinoma may be radioresistant and contribute to inferior survival outcomes. [8][9][10][11] Based on systemic treatment, it is of great significance to investigate the optimal local treatment strategies based on different histology in patients with Stage IVB cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Local treatment strategies in Stage IVB cervical squamous cell carcinoma and adenocarcinoma

Xu,

Hu,

et al. 2023

Intl J Gynecology & Obste

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ObjectiveTo evaluate the effect of different local treatment strategies on survival outcomes in patients with Stage IVB cervical squamous cell carcinoma (SCC) and adenocarcinoma.MethodsPatients diagnosed with Stage IVB cervical SCC and adenocarcinoma between 2004 and 2015 were included from the Surveillance, Epidemiology, and End Results (SEER) database. Subgroup analysis was performed in those diagnosed between 2010 and 2015 and available for the sites of distant metastases.ResultsIn total, 706 patients were identified in this study, including 378 (53.5%) and 328 (46.5%) diagnosed in 2004–2009 and 2010–2015, respectively. There were 525 (74.4%) and 181 (25.6%) patients with SCC and adenocarcinoma, respectively. Moreover, 274 (38.8%) and 432 (61.2%) patients received hysterectomy and primary radiotherapy, respectively. The results of the multivariate Cox regression analysis showed that histology and local treatment strategies were not related to cause‐specific survival (CSS) and overall survival. In the SCC patients, patients who received primary radiotherapy had similar CSS (P = 0.312) and overall survival (P = 0.390) compared with those treated with surgery. In the adenocarcinoma patients, those who received primary radiotherapy had inferior CSS (P = 0.003) and overall survival (P < 0.001) compared with those treated with surgery. Similar results were found in those diagnosed 2004–2015 and 2010–2015 after propensity score matching.ConclusionsFor patients with Stage IVB cervical cancer who received local therapy, surgery, and primary radiotherapy had similar survival in cervical SCC, whereas surgery had better survival outcomes compared with primary radiotherapy in those with cervical adenocarcinoma.

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Comparison of survival outcomes between squamous cell carcinoma and adenocarcinoma/adenosquamous carcinoma of the cervix after radical radiotherapy and chemotherapy

Cited by 11 publications

References 25 publications

The risk and latency evaluation of secondary primary malignancies of cervical cancer patients who received radiotherapy: A study based on the SEER database

The risk and latency evaluation of secondary primary malignancies of cervical cancer patients who received radiotherapy: A study based on the SEER database

Development and validation of a nomogram to predict overall survival for cervical adenocarcinoma: A population-based study

Local treatment strategies in Stage IVB cervical squamous cell carcinoma and adenocarcinoma

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