2020
DOI: 10.1158/1940-6207.capr-19-0356
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Comparison of Systemic Exposure to Toxic and/or Carcinogenic Volatile Organic Compounds (VOC) during Vaping, Smoking, and Abstention

Abstract: ◥Comparisons of systemic exposure to toxicants during monitored cigarette smoking, electronic cigarette (e-cigarette) use, and abstention are needed to enhance our understanding of the risks of e-cigarette use (vaping). In a crossover study, we measured 10 mercapturic acid metabolites of volatile organic compounds (VOCs) in 24-hour urine samples collected from 36 dual users (8 women) of e-cigarettes and cigarettes during 2 days of ad libitum vaping or cigaretteonly use, and 2 days of enforced abstention. Conce… Show more

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Cited by 53 publications
(31 citation statements)
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“…E-cigarettes encompass a range of devices which heat and aerosolize a solution that typically contains nicotine and a mixture of propylene glycol, glycerin and various flavoring additives. Laboratory studies have shown that the amount and concentration of toxicants in e-cigarette aerosol are substantially lower than in cigarette smoke [ 7 , 8 , 9 ]. As such, e-cigarettes are often promoted as potentially-modified risk products compared with cigarettes, and the majority of adult e-cigarette users (vapers) are current or former cigarette smokers, many of whom reference ‘quitting smoking’ as a primary reason for initiating use [ 10 ].…”
Section: Introductionmentioning
confidence: 99%
“…E-cigarettes encompass a range of devices which heat and aerosolize a solution that typically contains nicotine and a mixture of propylene glycol, glycerin and various flavoring additives. Laboratory studies have shown that the amount and concentration of toxicants in e-cigarette aerosol are substantially lower than in cigarette smoke [ 7 , 8 , 9 ]. As such, e-cigarettes are often promoted as potentially-modified risk products compared with cigarettes, and the majority of adult e-cigarette users (vapers) are current or former cigarette smokers, many of whom reference ‘quitting smoking’ as a primary reason for initiating use [ 10 ].…”
Section: Introductionmentioning
confidence: 99%
“… 5 , 11 E-cigarette aerosols contain nicotine, flavorings, or other additives, while lacking the high levels of carcinogens found in conventional cigarette smoke. 12 To many adult smokers, e-cigarettes are used or viewed as cessation aids and are perceived as safer to use than conventional cigarettes. 13 , 14 However, it is well documented that the aerosol exhaled by e-cigarette users, referred to as secondhand aerosol (SHA), can contain harmful substances including nicotine, heavy metals, ultrafine particulate, volatile organic compounds such as formaldehyde and acetaldehyde, and other toxicants.…”
Section: Introductionmentioning
confidence: 99%
“…108 In general, regulatory action for e-cigarettes is complicated by the need to strike a balance between protection from harm for nonsmokers and harm reduction for current smokers. "Smokers who switch completely [to e-cigarettes] are exposed to lower levels of [certain] carcinogens and other toxicants," 90,109 says Gideon St.Helen, an assistant professor of medicine at the University of California, San Francisco. "This lowers the risk of several tobacco-related diseases and may result in a public health benefit.…”
Section: E-cigarette Regulationmentioning
confidence: 99%